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LF / LTF / Lactoferrin

lactotransferrin

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate.Lactotransferrin is a major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions. Has antimicrobial activity, which depends on the extracellular cation concentration. Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane. Can also prevent bacterial biofilm development in P.aeruginosa infection. Has weak antifungal activity against C.albicans. Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth. Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection. Can inhibit papillomavirus infections. Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling. Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells. Stimulates VEGFA-mediated endothelial cell migration and proliferation. Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs). Also binds specifically to pneumococcal surface protein A (pspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA.Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection. N-terminal region shows strong antifungal activity against C.albicans. Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site.Kaliocin-1 has antimicrobial activity and is able to permeabilize different ions through liposomal membranes.Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.Isoform DeltaLf: transcription factor with antiproliferative properties and ability to induce cell cycle arrest. Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.

Gene Name: lactotransferrin
Synonyms: LTF, GIG12, Growth-inhibiting protein 12, HLF2, Lactotransferrin, Lactoferrin, LF, Neutrophil lactoferrin, Talalactoferrin
Target Sequences: NM_002343 NP_002334.2 P02788

Publications (2)

1
Mesenteric Adipose-derived Stromal Cells From Crohn's Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis. Hoffman JM, Sideri A, Ruiz JJ, Stavrakis D, Shih DQ, Turner JR, Pothoulakis C, Karagiannides I. Cellular and molecular gastroenterology and hepatology. 2018 February;6:1-16. [Full Text Article] [PubMed:29928668] [PMC:PMC6008259]
2
Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage. Zhao X, Ting SM, Sun G, Roy-O'Reilly M, Mobley AS, Bautista Garrido J, Zheng X, Obertas L, Jung JE, Kruzel M, Aronowski J. Stroke; a journal of cerebral circulation. 2018 May;49:1241-1247. [Full Text Article] [PubMed:29636422] [PMC:PMC5915919]

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No (213)
LF / LTF / Lactoferrin Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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LF / LTF / Lactoferrin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
LF / LTF / Lactoferrin Antibody - Anti-LTF / Lactoferrin antibody IHC of human breast, ductal with secretion. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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LF / LTF / Lactoferrin Mouse anti-Human Monoclonal (1A1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
LF / LTF / Lactoferrin Antibody - Western blot of recombinant LF / LTF / Lactoferrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LF / LTF / Lactoferrin Rabbit anti-Dog Polyclonal (aa28-351) Antibody
Dog, Human
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
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LF / LTF / Lactoferrin Mouse anti-Bovine Monoclonal (a-bC-lobe) Antibody
Bovine
WB
Unconjugated
100 µg/$652
LF / LTF / Lactoferrin Antibody - Western blot of recombinant LF / LTF / Lactoferrin.
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LF / LTF / Lactoferrin Rabbit anti-Cow Polyclonal (aa25-352) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,324
LF / LTF / Lactoferrin Antibody - Western blot of recombinant LF / LTF / Lactoferrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LF / LTF / Lactoferrin Rabbit anti-Goat Polyclonal (aa25-352) Antibody
Goat, Rat
WB
Unconjugated
100 µl/$319; 200 µl/$366; 500 µl/$521; 1 ml/$599; 2 ml/$829; 5 ml/$1,359
LF / LTF / Lactoferrin Antibody - Anti-LTF / Lactoferrin antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LF / LTF / Lactoferrin Rabbit anti-Human Polyclonal (FITC) Antibody
Human
Flo, ICC, IF, IHC, IHC-P
FITC Conjugated
50 µg/$460
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LF / LTF / Lactoferrin Goat anti-Bovine Polyclonal (FITC) Antibody
Bovine
IHC
FITC Conjugated
100 µl/$300; 500 µl/$394
LF / LTF / Lactoferrin Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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LF / LTF / Lactoferrin Mouse anti-Human Monoclonal (4C5) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated
0.05 mg/$460
LF / LTF / Lactoferrin Antibody - LF / LTF / Lactoferrin3
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LF / LTF / Lactoferrin Mouse anti-Human Monoclonal (PE) (4C5) Antibody
Human
Flo, IF
PE Conjugated
2 ml/$501
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LF / LTF / Lactoferrin Mouse anti-Human Monoclonal (1A1) Antibody
Human
ELISA, WB
Unconjugated
0.2 mg/$407; 0.5 mg/$487
LF / LTF / Lactoferrin Antibody - Formalin-fixed and paraffin-embedded human prostate carcinoma with LTF Monoclonal Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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LF / LTF / Lactoferrin Mouse anti-Human Monoclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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LF / LTF / Lactoferrin Goat anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, ID, IHC, WB
Biotin Conjugated
1 ml/$438
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LF / LTF / Lactoferrin Mouse anti-Human Monoclonal (HRP) (NI 25) Antibody
Human
ELISA, IF, WB
HRP Conjugated
0.2 mg/$598
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LF / LTF / Lactoferrin Mouse anti-Human Monoclonal (Biotin) (NI 25) Antibody
Human
ELISA, IF, WB
Biotin Conjugated
0.2 mg/$598
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LF / LTF / Lactoferrin Mouse anti-Human Monoclonal (PE) (LF5-1D2) Antibody
Human
ELISA, Flo
PE Conjugated
100 Tests/$365
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LF / LTF / Lactoferrin Bovine anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
100 µg/$862
LF / LTF / Lactoferrin Antibody - Western blot of recombinant LF / LTF / Lactoferrin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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LF / LTF / Lactoferrin Rabbit anti-Mouse Polyclonal (aa550-707) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
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LF / LTF / Lactoferrin Mouse anti-Bovine Monoclonal (5F12,1,2) Antibody
Bovine
WB
Unconjugated
100 µg/$652
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LF / LTF / Lactoferrin Rabbit anti-Human Monoclonal (Preservative Free) (103) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
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LF / LTF / Lactoferrin Mouse anti-Human Monoclonal (119CT80.1.1) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
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LF / LTF / Lactoferrin Mouse anti-Human Monoclonal (APC) (119CT80.1.1) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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LF / LTF / Lactoferrin Mouse anti-Human Monoclonal (PE) (119CT80.1.1) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
LF / LTF / Lactoferrin Antibody - Immunohistochemistry - Anti-Lactoferrin Picoband antibody
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LF / LTF / Lactoferrin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
LF / LTF / Lactoferrin Antibody - Anti-LF / Lactoferrin antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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LF / LTF / Lactoferrin Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).