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ITPR1 / IP3 Receptor Type 1

inositol 1,4,5-trisphosphate receptor, type 1

This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene.

Gene Name: inositol 1,4,5-trisphosphate receptor, type 1
Family/Subfamily: Ion Channel , Inositol 1,4,5-triphosphate receptor
Synonyms: ITPR1, InsP3R-I, IP3R1, InsP3R, InsP3R type I, INSP3R1, IP3R, Opisthotonus, Pcp1, IP3 receptor, IP3 receptor isoform 1, SCA15, Spinocerebellar ataxia 15, Spinocerebellar ataxia 16, I145TR, IP3R 1, KIAA1754, SCA16, Type 1 InsP3 receptor
Target Sequences: NM_001099952 NP_002213.5 Q14643

Publications (4)

1
The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Gao Q, Zhang J, Wang X, Liu Y, He R, Liu X, Wang F, Feng J, Yang D, Wang Z, Meng A, Yan X. Nature communications. 2017 8:15279. (WB; Human) [Full Text Article] [PubMed:28589943] [PMC:PMC5467231]
2
PC-PLC is involved in osteoclastogenesis induced by TNF- alpha through upregulating IP3R1 expression. Xia L, Zhang D, Wang C, Wei F, Hu Y. FEBS letters. 2012 Sep;586:3341-8. [Full Text Article] [PubMed:22819818] Related Antibodies: LS-B2640.
3
Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10. Finton KA, Larimore K, Larman HB, Friend D, Correnti C, Rupert PB, Elledge SJ, Greenberg PD, Strong RK. PLoS pathogens. 2013 9:e1003639. [Full Text Article] [PubMed:24086134] [PMC:PMC3784475] Related Antibodies: LS-B2627.
4
Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death. Feng X, Krogh KA, Wu CY, Lin YW, Tsai HC, Thayer SA, Wei LN. Nature communications. 5:4487. [Full Text Article] [PubMed:25066731] [PMC:PMC4200015] Related Antibodies: LS-B6763.
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☰ Filters
Antibodies (31)
Proteins (1)
Primary (31)
Recombinant (1)
ITPR1 / IP3 Receptor Type 1 (32)
Human (31)
Mouse (22)
Rat (18)
Bovine (2)
Monkey (1)
IHC (18)
IHC-Fr (1)
IHC-P (7)
WB (16)
ELISA (11)
ICC (1)
IF (9)
IP (3)
Peptide-ELISA (4)
rabbit (29)
mouse (1)
rabbit-new zealand white (1)
Product Group
IHCPlus (4)
IgG (25)
IgG2a,k (1)
monoclonal mc (1)
polyclonal pc (30)
2B6 (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (28)
1540-1620 aa (2)
pSer1756 (2)
1700-1780 aa (1)
C-Terminus (1)
Internal (1)
N-Terminus (1)
aa1025-1050 (1)
aa1140-1190 (1)
aa1566-1615 (1)
aa1892-1911 (1)
aa2411-2758 (1)
aa2708-2758 (1)
aa700-750 (1)
pSer1598/1588 (1)
pSer1764 (1)
No (29)
Yes (3)
GST, N-terminus (1)
Human (1)
Wheat Germ Extract (1)
ITPR1 / IP3 Receptor Type 1 Antibody - Anti-ITPR1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (aa1892-1911) Antibody
Mouse, Bovine, Rat, Human, Monkey
ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$485
ITPR1 / IP3 Receptor Type 1 Antibody - Anti-ITPR1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ITPR1 / IP3 Receptor Type 1 Antibody - Anti-ITPR1 antibody IHC of human brain, cerebellum, Purkinje cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$485
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Rat Polyclonal (pSer1756) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$689
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (1540-1620 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ITPR1 / IP3 Receptor Type 1 Antibody - Anti-ITPR1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (aa1566-1615) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$460
Select
ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (aa1025-1050) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
ITPR1 / IP3 Receptor Type 1 Antibody - Immunohistochemistry image of paraffin-embedded human breast cancer at a dilution of 1:100
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (aa2708-2758) Antibody
Mouse, Human
IF, IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
ITPR1 / IP3 Receptor Type 1 Antibody - IP3 receptor antibody IHC-paraffin: Mouse Brain Tissue.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (aa2411-2758) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (1540-1620 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ITPR1 / IP3 Receptor Type 1 Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human cervix tissue using Inositol 1,4,5-trisphosphate R1 (Phospho-Ser1598/1588) antibody.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (pSer1598/1588) Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
ITPR1 / IP3 Receptor Type 1 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using InsP3R1 antibody.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
ITPR1 / IP3 Receptor Type 1 Antibody - Western blot of Phospho-IP3R-I (S1764) antibody
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (1700-1780 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ITPR1 / IP3 Receptor Type 1 Antibody - Rabbit antibody to IP3R 1 (700-750). IHC-P on paraffin sections of rat cerebellum. The animal was perfused using Autoperfuser at a pressure of 110 mm Hg with 300 ml 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered through a 0.2 micron filter. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1:1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris Hematoxylin.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (aa700-750) Antibody
Human
IHC
Unconjugated
100 µl/$393
ITPR1 / IP3 Receptor Type 1 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using IP3R1 (Phospho-Ser1764) Antibody. The picture on the right is blocked with the phospho peptide.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (pSer1764) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
ITPR1 / IP3 Receptor Type 1 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using ITPR1 Polyclonal Antibody at dilution of 1:40.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ITPR1 / IP3 Receptor Type 1 Antibody - Immunohistochemistry of paraffin-embedded Human brain using ITPR1 Polyclonal Antibody at dilution of 1:40.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ITPR1 / IP3 Receptor Type 1 Antibody - Immunofluorescence analysis of U2OS cells using ITPR1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
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ITPR1 / IP3 Receptor Type 1 Rabbit-New Zealand White anti-Human Polyclonal (aa1140-1190) Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
ITPR1 / IP3 Receptor Type 1 Antibody - Western blot analysis of Phospho-IP3 Receptor (Ser1756) using HeLa whole cells lysates
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal (pSer1756) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ITPR1 / IP3 Receptor Type 1 Antibody - Western blot analysis IP3 Receptor using HuvEc whole cells lysates
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ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ITPR1 / IP3 Receptor Type 1 Antibody - Immunofluorescence analysis of U2OS cells using ITPR1 Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
Select
ITPR1 / IP3 Receptor Type 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Select
ITPR1 / IP3 Receptor Type 1 Mouse anti-Human Monoclonal (2B6) Antibody
Human
ELISA
Unconjugated
100 µg/$423
Viewing 1-25 of 32 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).