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ITGAV/Integrin Alpha V/CD51

integrin, alpha V

ITGAV/Integrin Alpha V/CD51 is a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes.

Gene Name: integrin, alpha V
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGAV, CD51, CD51 antigen, Integrin, alpha V, MSK8, Integrin Alpha V, Integrin alpha-V, VNRA, Vitronectin receptor, Integrin alphaVbeta3, VTNR
Target Sequences: NM_002210 NP_002201.1 P06756

Publications (5)

1
Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells. Defilippi P, van Hinsbergh V, Bertolotto A, Rossino P, Silengo L, Tarone G. The Journal of cell biology. 1991 114:855-63. [PubMed:1869591] [PMC:PMC2289904]
2
Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow. Burdick MM, McCaffery JM, Kim YS, Bochner BS, Konstantopoulos K. American journal of physiology. Cell physiology. 2003 284:C977-87. [PubMed:12477667]
3
Molecular magnetic resonance imaging of angiogenesis in vivo using polyvalent cyclic RGD-iron oxide microparticle conjugates. Melemenidis S, Jefferson A, Ruparelia N, Akhtar AM, Xie J, Allen D, Hamilton A, Larkin JR, Perez-Balderas F, Smart SC, Muschel RJ, Chen X, Sibson NR, Choudhury RP. Theranostics. 2015 5:515-29. (IP; Mouse) [Full Text Article] [PubMed:25767618] [PMC:PMC4350013] Related Antibodies: LS-C57970.
4
Pulmonary pericytes regulate lung morphogenesis. Kato K, Diéguez-Hurtado R, Park DY, Hong SP, Kato-Azuma S, Adams S, Stehling M, Trappmann B, Wrana JL, Koh GY, Adams RH. Nature communications. 2018 June;9:2448. (Mouse) [Full Text Article] [PubMed:29934496] [PMC:PMC6015030] Related Antibodies: LS-C57970.
5
Tumour exosome integrins determine organotropic metastasis. Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn. Nature. 2015 November;527:329-35. [Full Text Article] [PubMed:26524530] [PMC:PMC4788391]
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Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
ITGAV/Integrin Alpha V/CD51 (8)
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GST (1)
His (1)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (4)
Human (5)
Mouse (1)
293T Cells (2)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (2)
ITGAV/Integrin Alpha V/CD51 Protein - Recombinant Integrin Alpha V By SDS-PAGE
Select
E. coli
His, N-Terminal
24.0 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
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HEK 293 Cells
Myc-DDK (Flag)
115.9 kDa
100 µg/$710
ITGAV/Integrin Alpha V/CD51 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
111 kDa
100 µg/$710
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Yeast
His
19.7 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
ITGAV/Integrin Alpha V/CD51 Protein - Recombinant  Integrin Alpha V By SDS-PAGE
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E. coli
His-T7
31.6 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
Select
293T Cells
Myc-DDK (Flag)
115.9 kDa
20 µg/$215
ITGAV/Integrin Alpha V/CD51 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
111 kDa
20 µg/$215
ITGAV/Integrin Alpha V/CD51 Protein - 12.5% SDS-PAGE of human ITGAV stained with Coomassie Blue
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Wheat Germ Extract
GST
142.4 kDa
2 µg/$439
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).