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ITGAL / CD11a

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGAL, CD11A, Integrin alpha-L, LFA-1 alpha, LFA-1A, Integrin gene promoter, Alpha polypeptide), CD11a antigen, LFA-1, LFA1A
Target Sequences: NM_002209 NP_002200.2 P20701

Publications (2)

1
ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes. Figenschau SL, Knutsen E, Urbarova I, Fenton C, Elston B, Perander M, Mortensen ES, Fenton KA. Scientific reports. 2018 August;8:11720. [Full Text Article] [PubMed:30082828] [PMC:PMC6079003] Related Antibodies: LS-B5915.
2
Plasmacytoid Dendritic Cells and Infected Cells Form an Interferogenic Synapse Required for Antiviral Responses. Sonia Assil, Séverin Coléon, Congcong Dong, Elodie Décembre, Lee Sherry, Omran Allatif, Brian Webster, Marlène Dreux. Cell host & microbe. 2019 May;25:730-745.e6. [Full Text Article] [PubMed:31003939]

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Antibodies (170)
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ITGAL / CD11a Antibody - Anti-ITGAL / CD11a antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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ITGAL / CD11a Goat anti-Human Polyclonal (aa953-965) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
ITGAL / CD11a Antibody - Human peripheral blood lymphocytes stained with purified HI111, followed by anti-mouse IgGs FITC
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ITGAL / CD11a Mouse anti-Human Monoclonal (HI111) Antibody
Rabbit, Dog, Sheep, Bovine, Cat, Human, Monkey, Baboon
Flo, IHC, IHC-Fr, WB
Unconjugated
100 µg/$277
ITGAL / CD11a Antibody - Surface staining of murine splenocytes using anti-CD11a monoclonal antibody (clone M17/4) purified.
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ITGAL / CD11a Rat anti-Mouse Monoclonal (Low Endotoxin) (M17/4) Antibody
Mouse
Flo, Func, IHC, IHC-Fr, IP
Unconjugated, Low Endotoxin
0.1 mg/$295
ITGAL / CD11a Antibody - Flow cytometry of LFA-1 / CD11a antibody This image was taken for the unmodified form of this product. Other forms have not been tested.
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ITGAL / CD11a Mouse anti-Human Monoclonal (Azide-free) (38) Antibody
Human
Flo, Func, WB
Unconjugated, Azide-free
100 µg/$411
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ITGAL / CD11a Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
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ITGAL / CD11a Mouse anti-Human Monoclonal (OFYS) Antibody
Human
Flo
Unconjugated
100 µg/$359
ITGAL / CD11a Antibody - Anti-LFA-1 / CD11a antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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ITGAL / CD11a Rabbit anti-Human Polyclonal (aa722-751) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$440
ITGAL / CD11a Antibody - Western blot analysis of extracts of various cell lines.
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ITGAL / CD11a Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$311; 100 µl/$389; 200 µl/$503
ITGAL / CD11a Protein - Recombinant Lymphocyte Function Associated Antigen 1 Alpha By SDS-PAGE
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E. coli
His, N-Terminal
32.7 kDa
10 µg/$284; 50 µg/$462; 200 µg/$922; 1 mg/$2,042; 5 mg/$3,221; 2 mg/$2,231
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ITGAL / CD11a Rat anti-Mouse Monoclonal (Azide-free) (I21/7) Antibody
Mouse
Flo, IHC, IP, WB
Unconjugated, Azide-free
500 µg/$830
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ITGAL / CD11a Mouse anti-Human Monoclonal (Biotin) (38) Antibody
Human
Flo, IHC, IP
Biotin Conjugated
100 Tests/$557
ITGAL / CD11a Antibody - IHC analysis of CD11a using anti-CD11a antibody. CD11a was detected in immunocytochemical section of U937 Cell. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-CD11a Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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ITGAL / CD11a Rabbit anti-Human Polyclonal Antibody
Human
Flo, ICC, IHC, WB
Unconjugated
10 µg/$318; 100 µg/$470
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ITGAL / CD11a Mouse anti-Human Monoclonal (38) Antibody
Human
Flo, IF, IHC-Fr, IP
Unconjugated
0.1 mg/$385
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ITGAL / CD11a Mouse anti-Human Monoclonal (38) Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$284
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ITGAL / CD11a Mouse anti-Human Monoclonal (Azide-free, Low Endotoxin) (38) Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated, Azide-free, Low Endotoxin
0.5 mg/$462
ITGAL / CD11a ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$856
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ITGAL / CD11a Mouse anti-Human Monoclonal (LFA-1/2) Antibody
Human
Flo, ICC
Unconjugated
1 ml/$680
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ITGAL / CD11a Mouse anti-Human Monoclonal (Azide-free) (MEM-83) Antibody
Human
Flo, Func, IP
Unconjugated, Azide-free
0.1 mg/$302
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ITGAL / CD11a Mouse anti-Human Monoclonal (NKI(SPV)-L16) Antibody
Human
Flo, IP
Unconjugated
100 µg/$822
ITGAL / CD11a Antibody - Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using CD11a mouse mAb with DAB staining.
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ITGAL / CD11a Mouse anti-Human Monoclonal (5G7C5) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$459
ITGAL / CD11a Antibody - CD11a Antibody flow cytometry.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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ITGAL / CD11a Mouse anti-Human Monoclonal (CRIS-3) Antibody
Human
ELISA, Flo, IF, IHC, IHC-Fr, IP
Unconjugated
20 µg/$371; 100 µg/$574
ITGAL / CD11a Antibody - CD11a Antibody flow cytometry.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ITGAL / CD11a Mouse anti-Human Monoclonal (Azide-free, BSA-free) (CRIS-3) Antibody
Human
ELISA, Flo, Func, IF, IHC, IHC-Fr, IP
Unconjugated, Azide-free, BSA-free
100 µg/$574
ITGAL / CD11a Antibody - Immunohistochemistry of paraffin-embedded human tonsil tissue using antibody at dilution of 1:100.
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ITGAL / CD11a Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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ITGAL / CD11a Mouse anti-Rat Monoclonal (PE) (WT.1) Antibody
Rat
Flo
PE Conjugated
50 µg/$357; 200 µg/$660
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ITGAL / CD11a Rat anti-Mouse Monoclonal (IBL-6/2) Antibody
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated
250 µg/$404
Viewing 1-25 of 186 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).