Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

IREB2 / IRP2

iron-responsive element binding protein 2

RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

Gene Name: iron-responsive element binding protein 2
Synonyms: IREB2, ACO3, Iron regulatory protein 2, IRP2AD, IRE-BP 2, IRP2
Target Sequences: NM_004136 P48200 P48200

Publications (7)

1
Regulation of iron metabolism in Hamp (-/-) mice in response to iron-deficient diet. Masaratana P, Patel N, Latunde-Dada GO, Vaulont S, Simpson RJ, McKie AT. European journal of nutrition. 2013 52:135-43. (WB; Mouse) [PubMed:22241739]
2
Alterations in renal iron metabolism caused by a copper/zinc-superoxide dismutase deficiency. Yoshihara D, Fujiwara N, Kato S, Sakiyama H, Eguchi H, Suzuki K. Free radical research. 2012 46:750-7. (WB; Mouse) [PubMed:22435664]
3
Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia. Whitnall M, Suryo Rahmanto Y, Huang ML, Saletta F, Lok HC, Gutirrez L, Lzaro FJ, Fleming AJ, St Pierre TG, Mikhael MR, Ponka P, Richardson DR. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:20590-5. (WB; Mouse) [PubMed:23169664] [PMC:PMC3528580]
4
Iron transport through ferroportin is induced by intracellular ascorbate and involves IRP2 and HIF2a. Scheers N, Sandberg AS. Nutrients. 2014 6:249-60. (WB; Human) [Full Text Article] [PubMed:24394537] [PMC:PMC3916859] Related Antibodies: LS-C80347.
5
Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM. Nature medicine. 2016 22:163-74. (ICC; Mouse) [Full Text Article] [PubMed:26752519] [PMC:PMC4742374] Related Antibodies: LS-B48.
6
Iron addiction: a novel therapeutic target in ovarian cancer. Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM, Torti SV. Oncogene. 2017 July;36:4089-4099. (Human) [Full Text Article] [PubMed:28319068] [PMC:PMC5540148]
7
BRAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumorigenesis. Horniblow RD, Bedford M, Hollingworth R, Evans S, Sutton E, Lal N, Beggs A, Iqbal TH, Tselepis C. Cancer science. 2017 June;108:1135-1143. (Human) [Full Text Article] [PubMed:28281325] [PMC:PMC5480081]
more

☰ Filters
Products
ELISA Kits (9)
Custom (3)
Sandwich (6)
IREB2 / IRP2 (9)
Human (4)
Mouse (1)
Rat (2)
Chicken (1)
Pig (1)
96-Well Strip Plate (9)
No (9)
Plasma (5)
Serum (5)
Tissue Homogenates (3)
IREB2 / IRP2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
IREB2 / IRP2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IREB2 / IRP2 ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$783
IREB2 / IRP2 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
IREB2 / IRP2 ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
IREB2 / IRP2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
IREB2 / IRP2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
IREB2 / IRP2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$893
IREB2 / IRP2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Viewing 1-9 of 9 product results


Filtered By:
Products: ELISA Kits


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).