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IL7R / CD127

interleukin 7 receptor

IL7R / CD127 is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found for this gene.

Gene Name: interleukin 7 receptor
Family/Subfamily: Interleukin
Synonyms: IL7R, CD127, CD127 antigen, IL-7RA, IL-7 receptor subunit alpha, IL7RA, ILRA, Interleukin 7 receptor, CDW127, IL-7R subunit alpha, IL-7R-alpha
Target Sequences: NM_002185 NP_002176.2 P16871

Publications (1)

1
Immunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease. Yasunaga M, Manabe S, Matsumura Y. Scientific reports. 2017 September;7:10735. (Mouse) [Full Text Article] [PubMed:28878234] [PMC:PMC5587554] Related Antibodies: LS-B2830.

☰ Filters
Products
Proteins (20)
Over-Expression Lysate (2)
Recombinant (18)
IL7R / CD127 (20)
Preservative Free (1)
No (20)
6His, C-terminus (1)
6His, N-terminus (2)
6His-SUMO, N-terminus (1)
Fc (1)
Fc, C-terminus (2)
Fc/His,C-terminus (1)
Fc-6His, C-terminus (1)
GST (1)
His (3)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (10)
Mouse (7)
Rat (2)
293T Cells (1)
Baculovirus (1)
CHO Cells (2)
E. coli (4)
HEK 293 Cells (2)
Human (1)
Human Cells (5)
Mammalian Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (6)
Low endotoxin level (8)
IL7R / CD127 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Baculovirus
6His, N-terminus
100 µg/$1,067; 20 µg/$447; 1 mg/$1,988
Select
Mammalian Cells
Fc/His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.8 kDa
10 µg/$281; 50 µg/$389
Select
Human Cells
Fc-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.8kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
IL7R / CD127 Protein - Recombinant Interleukin 7 Receptor By SDS-PAGE
Select
E. coli
His-GST
42.6 kDa
10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
Select
CHO Cells
None
52.8 kDa
25 µg/$511
Select
CHO Cells
None
52.8 kDa
25 µg/$511
IL7R / CD127 Protein - Recombinant Human IL-7 Receptor Subunit alpha/IL-7RA/CD127 (C-6His)
Select
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.7 kDa
10 µg/$276; 50 µg/$405
IL7R / CD127 Protein - 12.5% SDS-PAGE of human IL7R stained with Coomassie Blue
Select
Wheat Germ Extract
GST
77.9 kDa
10 µg/$479; 25 µg/$670
IL7R / CD127 Protein - Recombinant  Interleukin 7 Receptor By SDS-PAGE
Select
E. coli
His-T7
30.8 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
IL7R / CD127 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
100 µg/$499; 20 µg/$364; 1 mg/$1,683
IL7R / CD127 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
26.5 kDa
100 µg/$721
IL7R / CD127 Protein - Purified recombinant protein IL7R was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
49.4 kDa
20 µg/$1,107
IL7R / CD127 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
51.6 kDa
20 µg/$150
IL7R / CD127 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
51.6 kDa
100 µg/$494
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
26.3 kDa
100 µg/$926; 1 mg/$4,701
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.1 kDa
10 µg/$281; 50 µg/$389
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.1kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
IL7R / CD127 Protein - Recombinant Interleukin 7 Receptor By SDS-PAGE
Select
E. coli
His
20.7 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
51.4 kDa
50 µg/$483
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).