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IL23A / IL-23 p19

interleukin 23, alpha subunit p19

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Gene Name: interleukin 23, alpha subunit p19
Family/Subfamily: Interleukin
Synonyms: IL23A, IL-23 subunit alpha, IL-23A, Interleukin 23 p19 subunit, Interleukin-23 subunit alpha, IL23P19, Interleukin-23 subunit p19, p19, SGRF, IL-23, IL-23 p19, IL-23-A, IL-23p19
Target Sequences: NM_016584 NP_057668.1 Q9NPF7

Publications (4)

1
The involvement of IL-23 and the Th17 pathway in periodontitis. Ohyama H, Kato-Kogoe N, Kuhara A, Nishimura F, Nakasho K, Yamanegi K, Yamada N, Hata M, Yamane J, Terada N. Journal of dental research. 2009 88:633-8. [PubMed:19605880] Related Antibodies: LS-B3708.
2
Systemic and local interleukin-17 and linked cytokines associated with Sjgren's syndrome immunopathogenesis. Katsifis GE, Rekka S, Moutsopoulos NM, Pillemer S, Wahl SM. The American journal of pathology. 2009 175:1167-77. [PubMed:19700754] [PMC:PMC2731135] Related Antibodies: LS-B3708.
3
Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. Muehlbauer SM, Lima H, Goldman DL, Jacobson LS, Rivera J, Goldberg MF, Palladino MA, Casadevall A, Brojatsch J. The American journal of pathology. 2010 177:735-43. [PubMed:20595632] [PMC:PMC2913046] Related Antibodies: LS-B3708.
4
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Li H, Yao Q, Mariscal AG, Wu X, Hülse J, Pedersen E, Helin K, Waisman A, Vinkel C, Thomsen SF, Avgustinova A, Benitah SA, Lovato P, Norsgaard H, Mortensen MS, Veng L, Rozell B, Brakebusch C. Nature communications. 2018 April;9:1420. (Human) [Full Text Article] [PubMed:29650963] [PMC:PMC5897363] Related Antibodies: LS-B573.
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☰ Filters
Products
Proteins (12)
Over-Expression Lysate (2)
Recombinant (10)
IL23A / IL-23 p19 (12)
No (12)
6His, C-terminus (3)
6His, N-terminus (1)
Fc, C-terminus (1)
GST (1)
His (1)
His-SUMO, N-terminus (1)
Myc-DDK (Flag) (3)
Human (6)
Mouse (3)
293T Cells (1)
Baculovirus (1)
E. coli (3)
HEK 293 Cells (2)
Human (4)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (6)
Biologically active (1)
IL23A / IL-23 p19 Protein - 12.5% SDS-PAGE of human IL23A stained with Coomassie Blue
Select
Wheat Germ Extract
GST
47.1 kDa
10 µg/$479; 25 µg/$670
IL23A / IL-23 p19 Protein - Recombinant Mouse IL-23
Select
Baculovirus
None
Less than 1.0 EU/µg protein (determined by LAL method).
19.7&35.8kDa
10 µg/$304; 50 µg/$491
Select
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
56.9 kDa
10 µg/$308; 50 µg/$502
IL23A / IL-23 p19 Protein - Recombinant Human IL-23 alpha & Mouse IL-12 beta Heterodimer (C-6His)
Select
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
56.9 kDa
10 µg/$308; 50 µg/$502
IL23A / IL-23 p19 Protein - Recombinant Human Interleukin-23/IL-23 (C-Fc)
Select
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
81.3 kDa
10 µg/$356; 50 µg/$716
IL23A / IL-23 p19 Protein - Recombinant Human Interleukin-23/IL-23 (C-6His)
Select
Human
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
19.7&34.8 kDa
10 µg/$377; 50 µg/$800
IL23A / IL-23 p19 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
100 µg/$1,128; 20 µg/$721
IL23A / IL-23 p19 Protein - Purified recombinant protein IL23A was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
18.6 kDa
20 µg/$1,107
IL23A / IL-23 p19 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
20.77 kDa
20 µg/$150
IL23A / IL-23 p19 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
20.77 kDa
100 µg/$494
Select
E. coli
84 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
9.35 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
IL23A / IL-23 p19 Protein - Recombinant Interleukin 23 (IL23) by SDS-PAGE
Select
E. coli
His-SUMO, N-terminus
36kDa
10 µg/$291; 50 µg/$502; 200 µg/$1,002; 100 µg/$802; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).