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IL1R1

interleukin 1 receptor, type I

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Gene Name: interleukin 1 receptor, type I
Family/Subfamily: Interleukin
Synonyms: IL1R1, Antigen CD121a, D2S1473, IL-1R-1, IL-1R-alpha, IL-1RT-1, IL-1RT1, IL1R, IL1RA, IL1RT1, Interleukin receptor 1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, CD121A, CD121a antigen, Interleukin 1 receptor, type I, Interleukin-1 receptor type I, Interleukin-1 type i receptor, p80
Target Sequences: NM_000877 NP_000868.1 P14778

Publications (2)

1
IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression. Suzuki M, Hashizume M, Yoshida H, Shiina M, Mihara M. Cytokine. 2010 51:178-83. (WB) [PubMed:20403707]
2
The role of interleukin-1ß in human trophoblast motility. Prutsch N, Fock V, Haslinger P, Haider S, Fiala C, Pollheimer J, Knöfler M. Placenta. 2012 33:696-703. (ELISA; Human) [Full Text Article] [PubMed:22710193] Related Antibodies: LS-B2859.

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Products
Antibodies (149)
Primary (149)
IL1R1 (149)
Human (78)
Mouse (49)
Rat (39)
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Gibbon (3)
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Primate (3)
IHC (25)
IHC-P (9)
WB (109)
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ELISA (52)
Func (4)
ICC (1)
ID (2)
IF (1)
IP (16)
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Peptide-ELISA (2)
RIA (6)
rabbit (119)
mouse (10)
goat (1)
hamster (4)
rat (15)
Product Group
Coronavirus Antibodies Proteins cDNAs (149)
Cytokine Release Syndrome Antibodies (149)
IHCPlus (3)
IgG (40)
IgG1 (14)
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monoclonal mc (30)
polyclonal pc (119)
08 (1)
10 (1)
35730 (49/20) (1)
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D14e3 (2)
D14E3 (1)
D1f3 (2)
IL1-31-104.1.1 (1)
IL1-31-113.1.1 (1)
IL1-31-22.2.1 (1)
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APC (7)
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Unconjugated (65)
aa120-208 (10)
aa386-553 (10)
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aa20-338 (8)
aa21-109 (8)
aa226-318 (8)
aa226-352 (8)
aa422-450 (7)
aa474-503 (7)
pTyr496 (6)
Extracellular Domain (4)
aa488-537 (4)
aa18-320 (2)
31-80 aa, N-terminal (1)
pY496 (1)
No (148)
Yes (1)
IL1R1 Antibody - Anti-IL1R1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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IL1R1 Mouse anti-Human Monoclonal (Extracellular Domain) (IL1-31-22.2.1) Antibody
Human
ELISA, IHC, IHC-P, RIA
Unconjugated
50 µg/$460
IL1R1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL1R1 Rabbit anti-Human Polyclonal (aa488-537) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
IL1R1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL1R1 Rabbit anti-Human Polyclonal (aa488-537) (Biotin) Antibody
Mouse, Dog, Rat, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
IL1R1 Antibody - Anti-IL1R1 antibody IHC staining of human lung, macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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IL1R1 Rabbit anti-Human Polyclonal (aa474-503) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
IL1R1 Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.
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IL1R1 Rabbit anti-Human Polyclonal (aa18-320) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
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IL1R1 Goat anti-Human Polyclonal (Extracellular Domain) (APC) Antibody
Human
Flo
APC Conjugated
100 Tests/$896
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IL1R1 Mouse anti-Human Monoclonal (Extracellular Domain) (IL1-31-104.1.1) Antibody
Human
ELISA, IHC, RIA
Unconjugated
200 µg/$484
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IL1R1 Mouse anti-Human Monoclonal (4D2D12) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
IL1R1 Antibody - Immunofluorescent analysis of A549 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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IL1R1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
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IL1R1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
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IL1R1 Rat anti-Mouse Monoclonal Antibody
Mouse
Func, ID, IP, Neut, WB
Unconjugated
100 µg/$752
IL1R1 Antibody - Western blot of recombinant IL1RA / IL1R1.
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IL1R1 Rabbit anti-Mouse Polyclonal (aa20-338) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
IL1R1 Antibody - Western blot of recombinant IL1RA / IL1R1.
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IL1R1 Rabbit anti-Mouse Polyclonal (aa20-338) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$483; 200 µl/$599; 500 µl/$1,089; 1 ml/$1,297; 2 ml/$1,815; 5 ml/$3,403
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IL1R1 Rabbit anti-Mouse Monoclonal (PE) Antibody
Mouse
Flo
PE Conjugated
25 Tests/$233; 100 Tests/$263
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IL1R1 Rat anti-Mouse Monoclonal Antibody
Mouse
Func, ID, Neut, WB
Unconjugated
100 µg/$826
IL1R1 Antibody - Immunohistochemistry of paraffin-embedded human kidney using antibody at 1:100 dilution.
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IL1R1 Rabbit anti-Human Polyclonal (aa18-320) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
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IL1R1 Rabbit anti-Human Polyclonal (pY496) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IL1R1 Antibody - Western blot of IL-1RI antibody
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IL1R1 Rabbit anti-Human Polyclonal (31-80 aa, N-terminal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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IL1R1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
Flo
Unconjugated
100 µl/$412
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IL1R1 Rat anti-Mouse Monoclonal (CF) Antibody
Mouse
Flo
CF Conjugated
100 Tests/$678
IL1R1 Antibody - Western blot of recombinant IL1RA / IL1R1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL1R1 Rabbit anti-Rat Polyclonal (aa386-553) (FITC) Antibody
Rat
WB
FITC Conjugated
100 µl/$325
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IL1R1 Rabbit anti-Human Polyclonal (aa474-503) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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IL1R1 Mouse anti-Human Monoclonal (Extracellular Domain) (IL1-31-113.1.1) Antibody
Human
ELISA, IHC, RIA
Unconjugated
200 µg/$484
IL1R1 Antibody - Western Blot; Sample: Recombinant IL1R1, Human.
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IL1R1 Rabbit anti-Human Polyclonal (aa21-109) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
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IL1R1 Rabbit anti-Human Polyclonal (pTyr496) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$554
Viewing 1-25 of 149 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).