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Human IgM

Immunoglobulin M, or IgM for short, is a basic antibody that is produced by B cells. IgM is by far the physically largest antibody in the human circulatory system. It is the first antibody to appear in response to initial exposure to an antigen. The spleen where plasmablasts reside is the major site of specific IgM production. IgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, mostly as a pentamer but also as a hexamer. IgM has a molecular mass of approximately 970 kDa (in its pentamer form). Because each monomer has two antigen binding sites, a pentameric IgM has 10 binding sites. Typically, however, IgM cannot bind 10 antigens at the same time because the large size of most antigens hinders binding to nearby sites. The J chain is found in pentameric IgM but not in the hexameric form, perhaps due to space constraints in the hexameric complex. Pentameric IgM can also be made in the absence of J chain. At present, it is still uncertain what fraction of normal pentamer contains J chain, and to this extent it is also uncertain whether a J chain-containing pentamer contains one or more than one J chain. Although hexameric IgM without J chain has higher efficiency of complement fixation than pentameric IgM with J chain. Because IgM is a large molecule, it cannot diffuse well, and is found in the interstitium only in very low quantities. IgM is primarily found in serum; however, because of the J chain, it is also important as a secretory immunoglobulin. Due to its polymeric nature, IgM possesses high avidity, and is particularly effective at complement activation. By itself, IgM is an ineffective opsonin; however it contributes greatly to opsonization by activating complement and causing C3b to bind to the antigen.

Human IgM Target Details

Target Name: Human IgM

Publications (1)

1
Salidroside attenuates hypoxia/reoxygenation-induced human brain vascular smooth muscle cell injury by activating the SIRT1/FOXO3a pathway. Xu L, Jia L, Wang Q, Hou J, Li S, Teng J. Experimental and therapeutic medicine. 2018 January;15:822-830. (Human) [Full Text Article] [PubMed:29434685] [PMC:PMC5772920]

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Human IgM Antibody - Flow cytometry of Human IgM antibody This image was taken for the unmodified form of this product. Other forms have not been tested.
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Human IgM Mouse anti-Human Monoclonal (Azide-free) (UCHB1) Antibody
Human
Flo, Func
Unconjugated, Azide-free
100 µg/$411
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Human IgM Mouse anti-Human Monoclonal Antibody
Human
ELISA, LateralFlow
Unconjugated
1 mg/$368
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Human IgM Rat anti-Human Monoclonal (HM-7) Antibody
Human
ELISA
Unconjugated
0.5 mg/$525
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Human IgM Goat anti-Human Polyclonal (Fab'2, Azide-free, Low Endotoxin) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated, Fab'2, Azide-free, Low Endotoxin
0.5 mg/$475
Human IgM Antibody - Over night cultured human peripheral blood lymphocytes stained with purified MHM-88, followed by anti-mouse IgG FITC
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Human IgM Mouse anti-Human Monoclonal (MHM-88) Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$276
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Human IgM Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, ID, IHC, IP, WB
Unconjugated
2 mg/$280
Human IgM ELISA Kit
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Sandwich
96-Well Strip Plate
Human
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$344
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Human IgM Rabbit Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$300
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Human IgM Goat anti-Human Polyclonal (Fab'2) (PE) Antibody
Human
FLISA, Flo
PE Conjugated, Fab'2
0.25 mg/$448
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Human IgM Goat anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
1 mg/$295
Human IgM Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with anti-IgM antibody (IM260 + IM373 + ICO-30).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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Human IgM Mouse anti-Human Monoclonal (Azide-free, BSA-free) (IM260 + IM373 + ICO-30) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
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Human IgM Goat anti-Human Polyclonal (RPE) Antibody
Human
Flo
RPE Conjugated
0.5 ml/$446
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Human IgM Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IP
Unconjugated
200 µg/$725
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Human IgM Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, ID, IHC, IP, WB
Unconjugated
1 mg/$334
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Human IgM Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, Flo, ID, IF, IHC, IP, WB
FITC Conjugated
1 mg/$389
Human IgM Antibody - IHC analysis of FFPE human tonsil tissue and IgM antibody (MuHC2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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Human IgM Mouse anti-Human Monoclonal (MuHC2) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
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Human IgM Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
1 mg/$272
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Human IgM Mouse anti-Human Monoclonal (HRP) Antibody
Dog, Pig, Cat, Horse, Human, Monkey
ELISA, Flo, IHC, WB
HRP Conjugated
100 µl/$1,027
Human IgM Antibody - Surface staining of human peripheral blood cells with anti-human IgM (CH2) FITC.
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Human IgM Mouse anti-Human Monoclonal (FITC) (CH2) Antibody
Human
ELISA, Flo, ICC, WB
FITC Conjugated
0.1 mg/$316
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None
2 mg/$472
Human IgM ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
7.81 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$476
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Human IgM Goat anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IF, IHC, WB
Biotin Conjugated
1 mg/$567
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Human IgM Goat anti-Human Polyclonal (AP) Antibody
Human
ELISA, IHC, WB
AP Conjugated
1 mg/$626
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Human IgM Mouse anti-Human Monoclonal (HRP) (NI 179) Antibody
Human
DB, ELISA, ICC, IHC, IHC-P
HRP Conjugated
0.2 mg/$598
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Human IgM Goat anti-Human Polyclonal (HRP) Antibody
Human
ELISA, Flo, ID, IHC, IP, WB
HRP Conjugated
1 mg/$289
Viewing 1-25 of 243 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).