Products
Services
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

HTT / Huntingtin

huntingtin

Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression.

Gene Name: huntingtin
Family/Subfamily: Hungtintin , Not assigned-Other
Synonyms: HTT, Huntingtin, Huntington disease protein, IT15, HD, HD protein
Target Sequences: NM_002111 NP_002102.4 P42858

Publications (2)

1
Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease. Cho KJ, Lee BI, Cheon SY, Kim HW, Kim HJ, Kim GW. Neuroscience. 2009 163:1128-34. (IHC, WB) [PubMed:19646509]
2
Adeno-Associated Viral Vector Serotype DJ-Mediated Overexpression of N171-82Q-Mutant Huntingtin in the Striatum of Juvenile Mice Is a New Model for Huntington's Disease. Jang M, Lee SE, Cho IH. Frontiers in cellular neuroscience. 2018 June;12:157. (Human) [Full Text Article] [PubMed:29946240] [PMC:PMC6005874] Related Antibodies: LS-C24591.


HTT / Huntingtin Antibody - Human Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Neuroscience
Mouse Monoclonal [clone HDC8A4] (IgG1)
Rabbit, Mouse, Human
IHC-P, IP, WB
Unconjugated
0.1mg   1mg/ml   $485.00
HTT / Huntingtin Antibody - Anti-HTT / Huntingtin antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 3F1] (IgG2a,k) to Human HTT / Huntingtin
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
HTT / Huntingtin Antibody - Anti-HTT / Huntingtin antibody IHC of human brain cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human HTT / Huntingtin
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $485.00
HTT / Huntingtin Antibody - Anti-HTT / Huntingtin antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human HTT / Huntingtin
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
HTT / Huntingtin Antibody - Anti-HTT / Huntingtin antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal (IgG1) to Human HTT / Huntingtin
Rabbit, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µg   1mg/ml   $485.00
Select
Goat Polyclonal (IgG) to Human HTT / Huntingtin
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
600µg   3mg/ml   $405.00
Select
Mouse Monoclonal [clone H.F5] (IgG) to Human HTT / Huntingtin
Mouse, Human
IHC, WB
Unconjugated
100µg   1mg/ml   $385.00
HTT / Huntingtin Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone 2Q75] (IgG1,k) to Human HTT / Huntingtin
Rat, Human, Monkey
ELISA, ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100µl   $800.00
HTT / Huntingtin Antibody - Western Blot of Rabbit Anti-Huntington antibody. Lane 1: mouse brain extract absence of blocking peptide. Lane 2: mouse brain extract with blocking peptide. Load: 10 µg per lane. Primary antibody: Huntington antibody at 0.1µg/mL for overnight at 4°C. Secondary antibody: IRDye800™ rabbit secondary antibody at 1:10,000 for 45 min at RT.
Select
Rabbit Polyclonal (IgG) to Human HTT / Huntingtin
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µg   1.1mg/ml   $425.00
Select
Rabbit Polyclonal to Human HTT / Huntingtin
Human
ELISA
Unconjugated
100µg   $755.00
Select
Rabbit Polyclonal (IgG) to Human HTT / Huntingtin
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µg   1mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Human HTT / Huntingtin
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µg   1.07mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Human HTT / Huntingtin
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µg   1.08mg/ml   $425.00
Select
Mouse Monoclonal [clone HDB4E10] (IgG1)
Mouse, Human
IHC-Fr, IP, WB
Unconjugated
0.1mg   1mg/ml   $445.00
Select
Mouse Monoclonal (IgG) to Human HTT / Huntingtin
Human
WB
Unconjugated
100µg   $530.00
HTT / Huntingtin Antibody - WB of HTT / Huntingtin antibody. All lanes: Anti-HTT at 0.5ug/ml. Lane 1: HELA Whole Cell Lysate at 40ug. Lane 2: U87 Whole Cell Lysate at 40ug. Predicted bind size: 348KD. Observed bind size: 348KD.
Select
Rabbit Polyclonal to Human HTT / Huntingtin
Mouse, Rat, Human
WB
Unconjugated
100µg   0.5mg/ml   $325.00
Select
Mouse Monoclonal (IgG2b) to Human HTT / Huntingtin
Mouse, Human
ELISA, ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100µl   $770.00
Select
Mouse Monoclonal (IgG1) to Human HTT / Huntingtin
Human, Monkey
ELISA, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µl   $785.00
Select
Mouse Monoclonal (IgG1) to Human HTT / Huntingtin
Rabbit
IHC, IHC-Fr, IP, WB
Unconjugated
100µg   $680.00
HTT / Huntingtin Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using Huntingtin antibody.
Select
Rabbit Polyclonal (IgG) to Human HTT / Huntingtin
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
100µg   $305.00
HTT / Huntingtin Antibody - Immunohistochemistry of paraffin-embedded rat brain tissue slide using Huntingtin antibody at dilution of 1:200
Select
Rabbit Polyclonal (IgG) to Human HTT / Huntingtin
Mouse, Human
ELISA, IF, IHC
Unconjugated
100µg   $325.00
Select
Rabbit Polyclonal (IgG) to Human HTT / Huntingtin
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µg   1mg/ml   $425.00
HTT / Huntingtin Antibody - Western blot of immunized recombinant protein using HD antibody.
Select
Mouse Monoclonal [clone 2401C1a] (IgG2b) to Human HTT / Huntingtin
Human
DB, ICC, WB
Unconjugated
100µg   100µg/ml   $530.00
Select
Rabbit Polyclonal (IgG) to Human HTT / Huntingtin
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human HTT / Huntingtin
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Viewing 1-25 of 54 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).