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HP / Haptoglobin

haptoglobin

HP / Haptoglobin is a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: haptoglobin
Synonyms: HP, Binding peptide, Haptoglobin alpha(1S)-beta, Haptoglobin, beta polypeptide, Haptoglobin, Haptoglobin alpha(2FS)-beta, Haptoglobin, alpha polypeptide, HP2ALPHA2, BP, Zonulin, HPA1S
Target Sequences: NM_005143 NP_005134.1 P00738

Publications (7)

1
Randomized, controlled trial evaluating the effect of multi-strain probiotic on the mucosal microbiota in canine idiopathic inflammatory bowel disease. White R, Atherly T, Guard B, Rossi G, Wang C, Mosher C, Webb C, Hill S, Ackermann M, Sciabarra P, Allenspach K, Suchodolski J, Jergens AE. Gut microbes. 2017 September;8:451-466. [Full Text Article] [PubMed:28678609] [PMC:PMC5628651] Related Antibodies: LS-C132998.
2
Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease. Atherly T, Rossi G, White R, Seo YJ, Wang C, Ackermann M, Breuer M, Allenspach K, Mochel JP, Jergens AE. PloS one. 2019 December;14:e0226780. [Full Text Article] [PubMed:31887117] [PMC:PMC6936794] Related Antibodies: LS-C132998.
3
Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia. Isabelle S Massart, Geneviève Paulissen, Audrey Loumaye, Pascale Lause, Sarah A Pötgens, Morgane M Thibaut, Estelle Balan, Louise Deldicque, Azeddine Atfi, Edouard Louis, Damien Gruson, Laure B Bindels, Marie-Alice Meuwis, Jean-Paul Thissen. Cancers. 2020 October;12: [Full Text Article] [PubMed:33142864] [PMC:PMC7693727] Related Antibodies: LS-C404051.
4
Histamine promotes adhesion of neutrophils by inhibition of autophagy in dairy cows with subacute ruminal acidosis. Kexin Wang, Zhenai Sun, Yunfei Li, Mingchao Liu, Juan J Loor, Qianming Jiang, Guowen Liu, Zhe Wang, Yuxiang Song, Xinwei Li. Journal of dairy science. 2022 September;105:7600-7614. [Full Text Article] [PubMed:35940921]
5
Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Yuxiang Song, Shang Jiang, Congyi Li, Juan J Loor, Qianming Jiang, Yuchen Yang, Xiancheng Feng, Siyuan Liu, Jiyuan He, Kexin Wang, Yunfei Li, Cai Zhang, Xiliang Du, Zhe Wang, Xinwei Li, Guowen Liu. Journal of dairy science. 2022 March;105:2473-2486. [Full Text Article] [PubMed:34998570]
6
Combination of haptoglobin and osteopontin could predict colorectal cancer hepatic metastasis. Sun L, Pan J, Peng L, Fang L, Zhao X, Sun L, Yang Z, Ran Y. Annals of surgical oncology. 2012 Jul;19:2411-9. [Full Text Article] [PubMed:22219064] Related Antibodies: LS-B32.
7
The extracellular chaperone haptoglobin prevents serum fatty acid-promoted amyloid fibril formation of beta 2-microglobulin, resistance to lysosomal degradation, and cytotoxicity. Sultan A, Raman B, Rao ChM, Tangirala R. The Journal of biological chemistry. 2013 Nov;288:32326-42. [Full Text Article] [PubMed:24078632] [PMC:PMC3820869] Related Antibodies: LS-B32.
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HP / Haptoglobin (38)
Human (11)
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96-Well Strip Plate (30)
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Plasma (32)
Serum (34)
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HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
HP / Haptoglobin ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$818
HP / Haptoglobin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$561
HP / Haptoglobin ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
31.25 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$889
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$644
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
HP / Haptoglobin ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
31.25 - 2000 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HP / Haptoglobin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
12.5 - 800 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HP / Haptoglobin ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HP / Haptoglobin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HP / Haptoglobin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78.125 - 5000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Canine
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Bovine
0.781 - 50 µg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
HP / Haptoglobin ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
HP / Haptoglobin ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
HP / Haptoglobin ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
3.125 - 200 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
HP / Haptoglobin ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
15.625 - 1000 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
78.125 - 5000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
HP / Haptoglobin ELISA Kit
Select
Sandwich
96-Well Microplate
Pig
62.5 - 4000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
HP / Haptoglobin ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
3.125 - 200 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
HP / Haptoglobin ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
1.1 - 800 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$968
HP / Haptoglobin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).