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Unfortunately, the antibody (ID:7913) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



GSK3B / GSK3 Beta

glycogen synthase kinase 3 beta

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity.

Gene Name: glycogen synthase kinase 3 beta
Family/Subfamily: Protein Kinase , GSK-3
Synonyms: GSK3B, GSK-3 beta, GSK3 beta, GSK3beta, GSK3beta isoform, TPKI, GSK 3beta, Tau protein kinase I, ZGSK-3beta
Target Sequences: NM_002093 NP_002084.2 P49841

Publications (2)

1
Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS. Allodi I, Comley L, Nichterwitz S, Nizzardo M, Simone C, Benitez JA, Cao M, Corti S, Hedlund E. Scientific reports. 2016 6:25960. (WB; Human) [Full Text Article] [PubMed:27180807] [PMC:PMC4867585] Related Antibodies: LS-B55.
2
Global quantitative phosphoproteome analysis of human tumor xenografts treated with a CD44 antagonist. Weigand S, Herting F, Maisel D, Nopora A, Voss E, Schaab C, Klammer M, Tebbe A. Cancer research. 2012 Sep;72:4329-39. [Full Text Article] [PubMed:22777824] Related Antibodies: LS-C96880.

Filtered By: None
Target
gsk3b-gsk3-beta (133)
Reactivity
Human (123)
Mouse (88)
Rat (67)
Bat (5)
Bovine (32)
Chicken (8)
Chimpanzee (3)
Dog (11)
Drosophila (1)
Gibbon (3)
Guinea pig (4)
Hamster (5)
Horse (8)
Monkey (10)
Pig (11)
Primate (1)
Rabbit (10)
Sheep (10)
Xenopus (5)
Zebrafish (7)
Application
IHC (60)
IHC-P (21)
WB (123)
Flo (6)
ELISA (64)
ICC (3)
IF (12)
IP (17)
PLA (1)
Host
rabbit (103)
mouse (27)
chicken (1)
rat (2)
Isotype
IgG (66)
IgG1 (3)
IgG1,k (9)
IgG2 (1)
IgG2a (8)
IgG2a,k (1)
IgG2b (5)
Clonality
monoclonal mc (30)
polyclonal pc (103)
Clone
1F7 (1)
1H3 (1)
3A11 (2)
3D10 (2)
5D6 (2)
TS106 (1)
Format
AP Conjugated (6)
APC Conjugated (6)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 565 Conjugated (1)
Atto 594 Conjugated (2)
Atto 633 Conjugated (1)
Atto 655 Conjugated (1)
Atto 680 Conjugated (1)
Atto 700 Conjugated (1)
Azide-free (3)
Biotin Conjugated (8)
CF Conjugated (1)
FITC Conjugated (8)
HRP Conjugated (10)
PE (1)
PE Conjugated (5)
PerCP Conjugated (1)
RPE Conjugated (1)
SA Conjugated (1)
Sepharose 4B Conjugated (1)
Sepharose Conjugated (1)
Unconjugated (75)
Epitope
C-Terminus (21)
pSer9 (14)
N-Terminus (10)
aa30-59 (7)
pSer29 (7)
aa326-375 (4)
aa1-50 (2)
aa1-80 (2)
aa335-349 (2)
aa341-420 (2)
pTyr216 (2)
Ser2 (1)
Ser9 (1)
Tyr216 (1)
aa1-100 (1)
aa29-59 (1)
aa370-420 (1)
aa4-34 (1)
pSer21/Ser29 (1)
Publications
No (131)
Yes (2)
Showing 1-25 out of 133 results
Anti-GSK3B / GSK3 Beta Antibody (phospho-Ser9) IHC-plus™ LS-B55

Rabbit Polyclonal to Human GSK3B / GSK3 Beta
Human
ELISA IHC-P IP WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody IHC-plus™ LS-B3691

Rabbit Polyclonal to Rat GSK3B / GSK3 Beta
Mouse, Bovine, Rat, Human
IF IHC-P WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (phospho-Ser21/Ser29) LS-C96880

Rabbit Polyclonal to Human GSK3B / GSK3 Beta
Mouse, Human
IHC-P WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (clone 3D10) LS-C108822

Mouse Monoclonal [clone 3D10] (IgG2a) to Human GSK3B / GSK3 Beta
Human
ELISA Flo IF IHC WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (phospho-Ser9) LS-C7174

Rabbit Polyclonal (IgG) to Human GSK3B / GSK3 Beta
Mouse, Rat, Human, Monkey
ELISA WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (aa335-349) LS-C7161

Rabbit Polyclonal (IgG) to Rat GSK3B / GSK3 Beta
Chicken, Bovine, Rat, Hamster, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
ICC IHC-P WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (clone 5D6, Sepharose) LS-C149600

Mouse Monoclonal [clone 5D6] (IgG2b) to Human GSK3B / GSK3 Beta
Human
IP
Sepharose Conjugated
Anti-GSK3B / GSK3 Beta Antibody LS-C497584

Rabbit Monoclonal to Human GSK3B / GSK3 Beta
Human
Flo IF IHC WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (phospho-Tyr216) LS-C335917

Rabbit Polyclonal (IgG) to Human GSK3B / GSK3 Beta
Mouse, Rat, Human
IF IHC WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody LS-C387788

Rabbit Polyclonal (IgG) to Mouse GSK3B / GSK3 Beta
Mouse, Rat
IHC WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (clone 3D10) LS-C359270

Mouse Monoclonal [clone 3D10] (IgG2a) to Human GSK3B / GSK3 Beta
Mouse, Rat, Primate, Human
ELISA Flo ICC IF IHC-P WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (phospho-Ser9) LS-C7153

Mouse Monoclonal (IgG1,k) to Human GSK3B / GSK3 Beta
Xenopus, Chicken, Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Human, Monkey
ELISA WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (N-Terminus) LS-C7171

Mouse Monoclonal (IgG1,k) to Human GSK3B / GSK3 Beta
Mouse, Dog, Rat, Human
ELISA WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (phospho-Ser9) LS-C352304

Rabbit Polyclonal to Human GSK3B / GSK3 Beta
Zebrafish, Pig, Mouse, Bovine, Rat, Human
IHC-P IP WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (C-Terminus, Biotin) LS-C229630

Rabbit Polyclonal to Human GSK3B / GSK3 Beta
Mouse, Bovine, Rat, Human
IHC WB
Biotin Conjugated
Anti-GSK3B / GSK3 Beta Antibody (aa4-34) LS-C101227

Rabbit Polyclonal to Human GSK3B / GSK3 Beta
Human
IHC-P WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody LS-C666011

Rabbit Polyclonal (IgG) to Human GSK3B / GSK3 Beta
Human
ELISA Flo IF IHC WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody LS-C666009

Rabbit Polyclonal (IgG) to Human GSK3B / GSK3 Beta
Human
ELISA IF IHC IP WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody LS-C666010

Rabbit Polyclonal (IgG) to Human GSK3B / GSK3 Beta
Human
ELISA IF IHC IP WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (aa1-80) LS-C383896

Rabbit Polyclonal (IgG) to Human GSK3B / GSK3 Beta
Mouse, Rat, Human
ELISA IHC IP WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (aa1-50) IHC-plus™ LS-B12429

Rabbit Polyclonal (IgG) to Human GSK3B / GSK3 Beta
Mouse, Rat, Human
ELISA IHC-P IP WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (aa326-375) IHC-plus™ LS-B5850

Rabbit Polyclonal (IgG) to Human GSK3B / GSK3 Beta
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC-P WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (C-Terminus) IHC-plus™ LS-B3267

Rabbit Polyclonal to Human GSK3B / GSK3 Beta
Mouse, Rat, Human
IHC-P WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody LS-C666007

Rabbit Polyclonal (IgG) to Human GSK3B / GSK3 Beta
Human
ELISA IHC IP WB
Unconjugated
Anti-GSK3B / GSK3 Beta Antibody (phospho-Ser9) LS-C380734

Rabbit Polyclonal (IgG) to Human GSK3B / GSK3 Beta
Mouse, Rat, Human
ELISA IHC IP WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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