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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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LSBio
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866-819-4732 (Toll Free North America
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GRK5

G protein-coupled receptor kinase 5

Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).

Gene Name: G protein-coupled receptor kinase 5
Family/Subfamily: Protein Kinase , GPRK
Synonyms: GRK5, FP2025, GPRK5
Target Sequences: NM_005308 NP_005299.1 P34947

Viewing 1-25 of 87 items
GRK5 Antibody - Anti-GRK5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Rabbit Polyclonal to Human GRK5
Chicken, Zebrafish, Pufferfish, Bovine, Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $425.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   0.35mg/ml   $425.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Dog, Bovine, Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Dog, Bovine, Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Dog, Bovine, Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Dog, Bovine, Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Dog, Bovine, Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Dog, Bovine, Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Dog, Bovine, Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
GRK5 Antibody - Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00

Viewing 1-25 of 87 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).