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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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GRK5

G protein-coupled receptor kinase 5

Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).

Gene Name: G protein-coupled receptor kinase 5
Family/Subfamily: Protein Kinase , GPRK
Synonyms: GRK5, FP2025, GPRK5
Target Sequences: NM_005308 NP_005299.1 P34947

Filtered by: None
Target
GRK5 (86)
Reactivity
Human (86)
Mouse (51)
Rat (40)
Bat (12)
Bovine (25)
Chicken (16)
Chimpanzee (6)
Dog (15)
Gibbon (6)
Guinea pig (8)
Horse (11)
Monkey (15)
Orangutan (6)
Pig (16)
Pufferfish (1)
Xenopus (4)
Zebrafish (9)
Application
IHC (43)
IHC-P (34)
WB (54)
ELISA (12)
IF (19)
IP (1)
Peptide-ELISA (1)
Host
rabbit (67)
mouse (19)
Isotype
IgG (22)
IgG1 (18)
IgG2a,k (1)
Clonality
monoclonal mc (19)
polyclonal pc (67)
Clone
1D9 (1)
S145-20 (18)
Format
AP Conjugated (6)
APC (1)
APC Conjugated (7)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 565 Conjugated (1)
Atto 594 Conjugated (2)
Atto 633 Conjugated (1)
Atto 655 Conjugated (1)
Atto 680 Conjugated (1)
Atto 700 Conjugated (1)
Azide-free (5)
Biotin Conjugated (10)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (10)
HRP Conjugated (10)
PE (1)
PE Conjugated (6)
PerCP Conjugated (1)
RPE Conjugated (1)
SA Conjugated (1)
Unconjugated (23)
Epitope
Internal (15)
N-Terminus (14)
aa304-532 (8)
aa559-590 (8)
aa290-339 (4)
aa369-418 (4)
320-400 aa, Internal (1)
Gln382 (1)
aa351-400 (1)
aa393-429 (1)
Publications
No (86)
Showing 1-25 of 86 results

IHC-plus™ GRK5 Antibody (N-Terminus) LS-A3470
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-GRK5 antibody IHC of human myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody LS-B1813
Rabbit Polyclonal to Human GRK5
Chicken, Zebrafish, Pufferfish, Bovine, Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-GRK5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Western blot of human GRK5 in human liver lysate in the 1) absence, 2) presence of immunizing peptide, 3) mouse and 4) rat liver using antibody at 0.5 ug/ml (human), 4.0 ug/ml (mouse) and 2 ug/ml (rat).

GRK5 Antibody (Internal) LS-C352276
Rabbit Polyclonal to Human GRK5
Mouse, Bovine, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of GRK5 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of GRK5 expression in H9C2 (A); HEK293T (B); HeLa (C) whole cell lysates.

IHC-plus™ GRK5 Antibody (Internal) LS-A3030
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 0.35mg/ml  $425.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (Internal, Biotin) LS-A103525
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (Internal, FITC) LS-A103526
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (Internal, APC) LS-A103524
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (Internal, PE) LS-A103528
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (Internal, Azide-free, HRP) LS-A103527
Rabbit Polyclonal to Human GRK5
Chicken, Bovine, Rat, Pig, Horse, Bat, Mouse, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GRK5 Antibody LS-C670188
Rabbit Polyclonal (IgG) to Human GRK5
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry image of paraffin-embedded human liver cancer at a dilution of 1:100
Immunofluorescence staining of HepG2 cells with GRK5 Antibody at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

GRK5 Antibody LS-C804500
Rabbit Polyclonal (IgG) to Human GRK5
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunofluorescence Image
Western blot Image

IHC-plus™ GRK5 Antibody (Internal) LS-A3034
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (Internal, Biotin) LS-A103531
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (Internal, FITC) LS-A103532
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (Internal, AP) LS-A103529
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (Internal, APC) LS-A103530
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (Internal, PE) LS-A103534
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (Internal, Azide-free, HRP) LS-A103533
Rabbit Polyclonal to Human GRK5
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (N-Terminus) LS-A3400
Rabbit Polyclonal to Human GRK5
Dog, Bovine, Human
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ GRK5 Antibody (N-Terminus, APC) LS-A103932
Rabbit Polyclonal to Human GRK5
Dog, Bovine, Human
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-GRK5 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GRK5 Antibody (aa393-429) LS-C407920
Rabbit Polyclonal to Human GRK5
Mouse, Bovine, Pig, Bat, Human
IHC, IHC-P, WB
Unconjugated
100µg  $355.00
GRK5 antibody IHC-paraffin. IHC(P): Rat Cardiac Muscle Tissue.
GRK5 antibody IHC-paraffin. IHC(P): Mouse Lung Tissue.

GRK5 Antibody LS-C490383
Rabbit Polyclonal (IgG) to Human GRK5
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µg  $435.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

GRK5 Antibody (aa559-590) LS-C98905
Rabbit Polyclonal to Human GRK5
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with GRK5 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

GRK5 Antibody (aa559-590) LS-C327491
Rabbit Polyclonal (IgG) to Human GRK5
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00

GRK5 Antibody (320-400 aa, Internal) LS-C383865
Rabbit Polyclonal (IgG) to Human GRK5
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of GRK 5 antibody
Western blot of GRK 5 antibody
Showing 1-25 of 86 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).