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Unfortunately, the antibody (ID:155906) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



GPER1 / GPR30

G protein-coupled estrogen receptor 1

G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.

Gene Name: G protein-coupled estrogen receptor 1
Family/Subfamily: GPCR , Transmembrane Estrogen Receptor
Synonyms: GPER1, CMKRL2, CEPR, FEG-1, G-protein coupled receptor 30, G protein-coupled receptor 30, GPCR-Br, GPER, Heptahelix receptor, LERGU, LyGPR, MER, GPR30, IL8-related receptor DRY12, LERGU2, Chemokine receptor-like 2, DRY12, Membrane estrogen receptor
Target Sequences: NM_001505 NP_001496.1 Q99527

Publications (18)

1
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Thomas P, Pang Y, Filardo EJ and Dong J. Endocrinology. 2005 146:624-32. (ICC; Human) [PubMed:15539556] Related Antibodies: LS-A1183.
2
The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells. Vivacqua A, Bonofiglio D, Recchia AG, Musti AM, Picard D, Andò S and Maggiolini M. Molecular endocrinology (Baltimore, Md.). 2006 20:631-46. (WB; Human) [PubMed:16239258] [PMC:PMC3060528] Related Antibodies: LS-A1183.
3
Impaired leukocyte influx in cervix of postterm women not responding to prostaglandin priming. Sahlin L, Stjernholm-Vladic Y, Roos N, Masironi B, Ekman-Ordeberg G. Reproductive biology and endocrinology : RB&E. 2008 6:36. (IHC-P; Human) [Full Text Article] [PubMed:18764934] [PMC:PMC2551600] Related Antibodies: LS-A4272.
4
Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF. Pandey DP, Lappano R, Albanito L, Madeo A, Maggiolini M, Picard D. The EMBO journal. 2009 28:523-32. (WB; Human) [Full Text Article] [PubMed:19153601] [PMC:PMC2657575] Related Antibodies: LS-A1183.
5
Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal - and -opioid receptor heterodimerization and female-specific spinal morphine antinociception. Liu NJ, Chakrabarti S, Schnell S, Wessendorf M, Gintzler AR. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:11836-45. (IHC-Fr; Rat) [Full Text Article] [PubMed:21849544] [PMC:PMC3321927] Related Antibodies: LS-A4272.
6
Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes. Rago V, Romeo F, Giordano F, Maggiolini M, Carpino A. Reproductive biology and endocrinology : RB&E. 2011 9:135. (WB, IHC-P; Human) [Full Text Article] [PubMed:21974818] [PMC:PMC3200171] Related Antibodies: LS-A4271.
7
Estradiol and GPER Activation Differentially Affect Cell Proliferation but Not GPER Expression in the Hippocampus of Adult Female Rats. Duarte-Guterman P, Lieblich SE, Chow C, Galea LA. PloS one. 2015 10:e0129880. (IF; Rat) [Full Text Article] [PubMed:26075609] [PMC:PMC4468121] Related Antibodies: LS-A4272.
8
GPR30 regulates the EGFR-Akt cascade and predicts lower survival in patients with ovarian cancer. Fujiwara S, Terai Y, Kawaguchi H, Takai M, Yoo S, Tanaka Y, Tanaka T, Tsunetoh S, Sasaki H, Kanemura M, Tanabe A, Yamashita Y, Ohmichi M. Journal of ovarian research. 2012 5:35. (WB; Human) [Full Text Article] [PubMed:23163984] Related Antibodies: LS-A4272.
9
G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol. Otto C, Rohde-Schulz B, Schwarz G, Fuchs I, Klewer M, Brittain D, Langer G, Bader B, Prelle K, Nubbemeyer R, Fritzemeier KH. Endocrinology. 2008 149:4846-56. (IF; Human, Monkey, Hamster) [Full Text Article] [PubMed:18566127] Related Antibodies: LS-A4272.
10
Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Li Y, Birnbaumer L, Teng CT. Molecular endocrinology (Baltimore, Md.). 2010 May;24:969-80. [Full Text Article] [PubMed:20211987] [PMC:PMC2870941] Related Antibodies: LS-A4272.
11
Stallion spermatozoa: putative target of estrogens; presence of the estrogen receptors ESR1, ESR2 and identification of the estrogen-membrane receptor GPER. Arkoun B, Gautier C, Delalande C, Barrier-Battut I, Gu[Character e9]non I, Goux D, Boura[Character ef]ma-Lelong H. General and comparative endocrinology. 2014 May;200:35-43. [Full Text Article] [PubMed:24607572] Related Antibodies: LS-A4272, LS-A1184, LS-A4271.
12
Inhibition of the AKT/mTOR and erbB pathways by gefitinib, perifosine and analogs of gonadotropin-releasing hormoneI andII to overcome tamoxifen resistance in breast cancer cells. Block M, Gr[Character fc]ndker C, Fister S, Kubin J, Wilkens L, Mueller MD, Hemmerlein B, Emons G, G[Character fc]nthert AR. International journal of oncology. 2012 Nov;41:1845-54. [Full Text Article] [PubMed:22922893] Related Antibodies: LS-A1183.
13
Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts. Madeo A, Maggiolini M. Cancer research. 2010 Jul;70:6036-46. [Full Text Article] [PubMed:20551055] Related Antibodies: LS-A4271.
14
Identification of G protein-coupled estrogen receptor in human and pig spermatozoa. Rago V, Giordano F, Brunelli E, Zito D, Aquila S, Carpino A. Journal of anatomy. 2014 Jun;224:732-6. [Full Text Article] [PubMed:24697543] Related Antibodies: LS-A4271.
15
Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice. Isensee J, Meoli L, Zazzu V, Nabzdyk C, Witt H, Soewarto D, Effertz K, Fuchs H, Gailus-Durner V, Busch D, Adler T, de Angelis MH, Irgang M, Otto C, Noppinger PR. Endocrinology. 2009 Apr;150:1722-30. [Full Text Article] [PubMed:19095739] Related Antibodies: LS-A4271.
16
G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells. Vivacqua A, Lappano R, De Marco P, Sisci D, Aquila S, De Amicis F, Fuqua SA, And[Character f2] S, Maggiolini M. Molecular endocrinology (Baltimore, Md.). 2009 Nov;23:1815-26. [Full Text Article] [PubMed:19749156] Related Antibodies: LS-A4271.
17
c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells. Madeo A, Vinciguerra M, Lappano R, Galgani M, Gasperi-Campani A, Maggiolini M, Musti AM. Oncogene. 2010 Feb;29:978-91. [Full Text Article] [PubMed:19935718] Related Antibodies: LS-A4271.
18
Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells. Lappano R, Rosano C, De Marco P, De Francesco EM, Pezzi V, Maggiolini M. Molecular and cellular endocrinology. 2010 May;320:162-70. [Full Text Article] [PubMed:20138962] Related Antibodies: LS-A4271.
more

Filtered By: None
Target
gper1-gpr30 (34)
Reactivity
Human (34)
Mouse (15)
Rat (5)
Chimpanzee (6)
Dog (6)
Guinea pig (1)
Horse (4)
Monkey (12)
Application
IHC (11)
IHC-Fr (1)
IHC-P (9)
WB (25)
ELISA (16)
ICC (1)
IF (5)
Host
rabbit (33)
goat (1)
Isotype
IgG (16)
Clonality
polyclonal pc (34)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (22)
Epitope
aa346-375 (8)
C-Terminus (5)
aa276-325 (4)
Extracellular Domain (3)
N-Terminus (2)
aa1-23 (2)
Cytoplasmic Domain (1)
aa275-288 (1)
aa351-375 (1)
aa357-370 (1)
aa362-375 (1)
Publications
No (30)
Yes (4)
Showing 1-25 out of 34 results
Anti-GPER1 / GPR30 Antibody (C-Terminus) IHC-plus™ LS-A4272
Anti-GPR30 antibody LS-A4272 IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPER1 / GPR30 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Rabbit Polyclonal to Human GPER1 / GPR30
Dog, Rat, Human, Monkey
IF IHC IHC-Fr IHC-P WB
Unconjugated
Anti-GPER1 / GPR30 Antibody (aa357-370) IHC-plus™ LS-B5132
Anti-GPR30 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5132 concentration 3.75 ug/ml.
Anti-GPR30 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5132 concentration 3.75 ug/ml.

Goat Polyclonal to Human GPER1 / GPR30
Dog, Human, Monkey
IHC IHC-P
Unconjugated
Anti-GPER1 / GPR30 Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1183
Anti-GPER1 / GPR30 antibody IHC of human breast, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPER1 / GPR30 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Rabbit Polyclonal to Human GPER1 / GPR30
Human
ICC IHC IHC-P WB
Unconjugated
Anti-GPER1 / GPR30 Antibody (Extracellular Domain) IHC-plus™ LS-A4271
Anti-GPR30 antibody LS-A4271 IHC of human brain, hippocampus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Rabbit Polyclonal to Human GPER1 / GPR30
Human, Monkey
IF IHC IHC-P WB
Unconjugated
Anti-GPER1 / GPR30 Antibody (Extracellular Domain) IHC-plus™ LS-A1184
Anti-GPER1 / GPR30 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPER1 / GPR30 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Rabbit Polyclonal to Human GPER1 / GPR30
Human
IF IHC IHC-P
Unconjugated
Anti-GPER1 / GPR30 Antibody (N-Terminus) IHC-plus™ LS-A4290
Anti-GPR30 antibody LS-A4290 IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPER1 / GPR30 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Rabbit Polyclonal to Human GPER1 / GPR30
Human
IF IHC IHC-P WB
Unconjugated
Anti-GPER1 / GPR30 Antibody (Extracellular Domain) IHC-plus™ LS-A4268
Anti-GPR30 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A4268 dilution 5-7.5 ug/ml.
Anti-GPR30 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-A4268 dilution 5-7.5 ug/ml.

Rabbit Polyclonal to Human GPER1 / GPR30
Human
ELISA IHC IHC-P
Unconjugated
Anti-GPER1 / GPR30 Antibody (N-Terminus) LS-C203019
Immunohistochemistry of human brain tissue slide (Paraffin embedded). using Rabbit Anti-GPR30 Polyclonal Antibody (Left) and Purified Rabbit IgG (whole molecule) Control (Right).

Rabbit Polyclonal to Human GPER1 / GPR30
Human
ELISA IHC IHC-P WB
Unconjugated
Anti-GPER1 / GPR30 Antibody (aa276-325) LS-C146295
GPER / GPR30 antibody LS-C146295 Western blot of Fetal Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal to Human GPER1 / GPR30
Mouse, Human, Monkey
WB
Unconjugated
Anti-GPER1 / GPR30 Antibody (aa275-288) LS-C313331
WB of GPER1 / GPR30 antibody. Lane 1: COLO320 Cell Lysate. Lane 2: MCF-7 Cell Lysate. Lane 3: COS7 Cell Lysate.

Rabbit Polyclonal to Human GPER1 / GPR30
Guinea pig, Rat, Human, Monkey
WB
Unconjugated
Anti-GPER1 / GPR30 Antibody (aa346-375) LS-C166606
GPER Antibody western blot of mouse liver tissue lysates (35 ug/lane). The GPER antibody detected the GPER protein (arrow).
GPER Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The GPER antibody detected the GPER protein (arrow).

Rabbit Polyclonal to Human GPER1 / GPR30
Mouse, Human
WB
Unconjugated
Anti-GPER1 / GPR30 Antibody (aa1-23) LS-C190874

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Mouse, Rat, Human
IHC IHC-P
Unconjugated
Anti-GPER1 / GPR30 Antibody LS-C678123
Immunohistochemistry of paraffin-embedded human placenta tissue at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Human
ELISA IF IHC WB
Unconjugated
Anti-GPER1 / GPR30 Antibody (aa362-375) LS-C403194
Immunohistochemistry of Human thyroid cancer using GPER1 Polyclonal Antibody at dilution of 1:25.
Western blot analysis of Human placenta tissue, HepG2 and A549 cell, using GPER1 Polyclonal Antibody at dilution of 1:350.

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
Anti-GPER1 / GPR30 Antibody (aa346-375) LS-C329592

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Mouse, Human
ELISA WB
Unconjugated
Anti-GPER1 / GPR30 Antibody (aa346-375, Biotin) LS-C257924

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Mouse, Human
ELISA WB
Biotin Conjugated
Anti-GPER1 / GPR30 Antibody (aa346-375, FITC) LS-C257923

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Mouse, Human
ELISA WB
FITC Conjugated
Anti-GPER1 / GPR30 Antibody (aa346-375, AP) LS-C257921

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Mouse, Human
ELISA WB
AP Conjugated
Anti-GPER1 / GPR30 Antibody (aa346-375, APC) LS-C257922

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Mouse, Human
ELISA WB
APC Conjugated
Anti-GPER1 / GPR30 Antibody (aa346-375, Azide-free, HRP) LS-C257925

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Mouse, Human
ELISA WB
HRP Conjugated, Azide-free
Anti-GPER1 / GPR30 Antibody (aa346-375, PE) LS-C257928

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Mouse, Human
ELISA WB
PE Conjugated
Anti-GPER1 / GPR30 Antibody (aa1-23) LS-C190875

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Human
ELISA
Unconjugated
Anti-GPER1 / GPR30 Antibody (aa351-375) LS-C190876

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Human
ELISA
Unconjugated
Anti-GPER1 / GPR30 Antibody LS-C678126

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Human
ELISA
Unconjugated
Anti-GPER1 / GPR30 Antibody LS-C678127

Rabbit Polyclonal (IgG) to Human GPER1 / GPR30
Human
ELISA
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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