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GPC1 / Glypican

glypican 1

Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.

Gene Name: glypican 1
Synonyms: GPC1, Glypican 1, Glypican, Glypican-1, Glypican proteoglycan 1
Target Sequences: NM_002081 NP_002072.2 P35052

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Proteins (14)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (1)
Recombinant (12)
GPC1 / Glypican (14)
No (14)
6His, C-terminus (3)
6His, N-terminus (2)
GST, N-terminus (2)
His (3)
His, N-Terminal (4)
Human (9)
Mouse (5)
E. coli (3)
HEK 293 Cells (4)
Human Cells (2)
Mammalian Cells (3)
Wheat Germ Extract (2)
Purified (2)
Supernatant (1)
Low endotoxin level (5)
Biologically active (1)
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Human Cells
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
57.7kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585
GPC1 / Glypican Protein - Recombinant Glypican 1 By SDS-PAGE
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E. coli
His
20.1 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
GPC1 / Glypican Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
56.7 kDa
50 µg/$453; 10 µg/$303; 1 mg/$2,837; 500 µg/$1,987
GPC1 / Glypican Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
GPC1 / Glypican Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
56.7 kDa
10 µg/$281; 50 µg/$389
Select
HEK 293 Cells
His, N-Terminal
56 kDa
50 µg/$677
Select
HEK 293 Cells
His, N-Terminal
~56 kDa
200 µl/$283
Select
HEK 293 Cells
His, N-Terminal
~56 kDa
100 µg/$298
Select
Mammalian Cells
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
57.7 kDa
10 µg/$281; 50 µg/$389
GPC1 / Glypican Protein
Select
HEK 293 Cells
His, N-Terminal
~55 kDa (60 kDa reducing conditions)
10 µg/$289; 100 µg/$432; 50 µg/$360
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
56.7kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
E. coli
His
23.5 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
Select
E. coli
His
17.0 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).