Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

GPBAR1 / TGR5

G protein-coupled bile acid receptor 1

GPBAR1 / TGR5 is a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene Name: G protein-coupled bile acid receptor 1
Family/Subfamily: GPCR , Bile Acids
Synonyms: GPBAR1, BG37, GPR131, HGPCR19, M-BAR, GPCR19, TGR5, GPCR TGR5, HBG37, Membrane bile acid receptor
Target Sequences: AB083601 NP_733800.1 Q8TDU6

Publications (2)

1
Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism. Pathak P, Liu H, Boehme S, Xie C, Krausz KW, Gonzalez F, Chiang JYL. The Journal of biological chemistry. 2017 June;292:11055-11069. (Human) [Full Text Article] [PubMed:28478385] [PMC:PMC5491788] Related Antibodies: LS-C47388.
2
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ. Molecular metabolism. 2018 May;11:84-95. (Human) [Full Text Article] [PubMed:29656109] [PMC:PMC6001409] Related Antibodies: LS-A1936.

☰ Filters
Products
Proteins (5)
Over-Expression Lysate (4)
Recombinant (1)
GPBAR1 / TGR5 (5)
No (5)
GST (1)
Myc-DDK (Flag) (4)
Human (3)
293T Cells (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
GPBAR1 / TGR5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
35.1 kDa
100 µg/$494
Select
HEK 293 Cells
Myc-DDK (Flag)
35.1 kDa
100 µg/$494
GPBAR1 / TGR5 Protein - 12.5% SDS-PAGE of human GPBAR1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
62.04 kDa
2 µg/$439
Select
293T Cells
Myc-DDK (Flag)
35.1 kDa
20 µg/$150
GPBAR1 / TGR5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35.1 kDa
20 µg/$150
Viewing 1-5 of 5 product results


Filtered By:
Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).