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Catalog Number Size Price
LS-A1936-50 50 µg (1 mg/ml) $440 
GPBAR1 / TGR5 Antibody - Lung, Non Small-Cell Carcinoma
GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPBAR1 / TGR5 Antibody - Pancreas, carcinoma
GPBAR1 / TGR5 Antibody - Breast, Carcinoma
GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPBAR1 / TGR5 Antibody - Anti-TGR5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPBAR1 / TGR5 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
GPBAR1 / TGR5 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
GPBAR1 / TGR5 Antibody - Lung, Non Small-Cell Carcinoma
GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPBAR1 / TGR5 Antibody - Pancreas, carcinoma
GPBAR1 / TGR5 Antibody - Breast, Carcinoma
GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPBAR1 / TGR5 Antibody - Anti-TGR5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPBAR1 / TGR5 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
GPBAR1 / TGR5 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PathPlus™ Polyclonal Rabbit anti‑Human GPBAR1 / TGR5 Antibody (C‑Terminus, IHC) LS‑A1936

PathPlus™ Polyclonal Rabbit anti‑Human GPBAR1 / TGR5 Antibody (C‑Terminus, IHC) LS‑A1936

Antibody:
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$440
LS-A1936-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
GPBAR1 / TGR5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
GPBAR1 (TGR5) is a member of the G protein-coupled receptor (GPCR) superfamily and functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPBAR1 with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. It is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. GPBAR1 inhibitors may be useful as treatments for polycystic liver disease and cholangiocarcinoma, as it has been found to be overexpressed in cholangiocarcinoma and cystic cholangiocytes and is thought to be involved in promoting proliferation and cyst growth. It has membranous and cytoplasmic positivity in a number of tissues, including the lung, gastrointestinal tract, gallbladder, bladder, pars intermedia of the pituitary gland, and faint to variable positivity in various locations in the central nervous system. References: Semin Liver Dis. 2018 Nov;38(4):333-339, PMID: 30357770
Target
Human GPBAR1 / TGR5
Synonyms
GPBAR1 | BG37 | GPR131 | HGPCR19 | M-BAR | GPCR19 | TGR5 | GPCR TGR5 | HBG37 | Membrane bile acid receptor
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from C-Terminus of human TGR5. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Marmoset (94%).
Epitope
C-Terminus
Specificity
Human TGR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (2.5 - 5 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GPBAR1 / TGR5
Q8TDU6 AB083601 NP_733800.1

Validation

GPBAR1 / TGR5 Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPBAR1 / TGR5 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPBAR1 / TGR5 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPBAR1 / TGR5 Antibody - Pancreas, carcinoma
Pancreas, carcinoma
Pancreas, carcinoma

GPBAR1 / TGR5 Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPBAR1 / TGR5 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPBAR1 / TGR5 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPBAR1 / TGR5 Antibody - Anti-TGR5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TGR5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TGR5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPBAR1 / TGR5 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPBAR1 / TGR5 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPBAR1 / TGR5 Antibody - Anti-GPBAR1 / TGR5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPBAR1 / TGR5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPBAR1 / TGR5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPBAR1 / TGR5 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

GPBAR1 / TGR5 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ GPBAR1 / TGR5 Antibody (C-Terminus) for IHC LS-A1936 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas. Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ. Molecular metabolism. 2018 May;11:84-95. (Human)

Customer Reviews (0)


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Requested From: United States
Date Requested: 9/27/2021