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Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.
Gene Name: | glycoprotein VI (platelet) |
Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
Synonyms: | GP6, BDPLT11, GPVI, Glycoprotein 6, GPIV, Platelet collagen receptor, Platelet glycoprotein VI, Glycoprotein VI (platelet), gp6 |
Target Sequences: | NM_016363 NP_001077368.2 Q9HCN6 |
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