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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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FBXW7 / FBW7

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

FBXW7 / FBW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Family/Subfamily: F-Box
Synonyms: FBXW7, AGO, Archipelago homolog, Archipelago, CDC4, F-box protein FBW7, FBXW6, F-box protein FBX30, F-box protein SEL-10, HCdc4, Homolog of C elegans sel-10, FBW6, FBX30, FBW7, HAgo, SEL-10, SEL10
Target Sequences: NM_018315 NP_060785.2 Q969H0


FBXW7 / FBW7 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
Mouse Monoclonal [clone 13H4] (IgG2b) to Human FBXW7 / FBW7
Human
IHC-P, WB
Unconjugated
50µl   $425.00
FBXW7 / FBW7 Antibody - Anti-FBXW7 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 3D1] (IgG2a,k) to Human FBXW7 / FBW7
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
FBXW7 / FBW7 Antibody - Anti-FBXW7 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Human
IHC, IHC-P, IP, WB
Unconjugated
50µg   0.25mg/ml   $485.00
FBXW7 / FBW7 Antibody - Anti-FBXW7 antibody IHC of mouse brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse FBXW7 / FBW7
Mouse, Rat, Hamster
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
FBXW7 / FBW7 Antibody - Anti-FBXW7 antibody IHC of mouse brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Mouse FBXW7 / FBW7
Mouse, Rat, Hamster
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $405.00
FBXW7 / FBW7 Antibody - Anti-FBXW7 antibody IHC of mouse brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse FBXW7 / FBW7
Mouse, Rat, Hamster
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $405.00
FBXW7 / FBW7 Antibody - Anti-FBXW7 antibody IHC of mouse brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse FBXW7 / FBW7
Mouse, Rat, Hamster
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $405.00
FBXW7 / FBW7 Antibody - Anti-FBXW7 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Xenopus, Chicken, Zebrafish, Drosophila, Pig, Horse, Bat, Rat, Hamster, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
FBXW7 / FBW7 Antibody - Anti-FBXW7 antibody IHC of human: brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
FBXW7 / FBW7 Antibody - Immunohistochemistry of paraffin-embedded mouse lung tissue.
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Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Mouse, Rat, Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   3.39mg/ml   $235.00; 100µl   $315.00; 200µl   $425.00
FBXW7 / FBW7 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FBXW7 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FBXW7.
Select
Mouse Monoclonal [clone OTI1C7] (IgG1) to Human FBXW7 / FBW7
Human
WB
Unconjugated
100µl   1mg/ml   $345.00
FBXW7 / FBW7 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI6F5] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
FBXW7 / FBW7 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI6F5] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
FBXW7 / FBW7 Antibody - IHC of paraffin-embedded Human colon tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI2G7] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
FBXW7 / FBW7 Antibody - IHC of paraffin-embedded Human colon tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI2G7] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
FBXW7 / FBW7 Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
FBXW7 / FBW7 Antibody - Immunohistochemistry analysis of human kidney tissue at a dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Human
ELISA, ICC, IHC
Unconjugated
50µg   $285.00; 100µg   $385.00
FBXW7 / FBW7 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone 13H4] (IgG2b) to Human FBXW7 / FBW7
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Human
ELISA, IHC, WB
Unconjugated
100µg   $375.00
FBXW7 / FBW7 Antibody - IHC of paraffin-embedded Human bladder tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI10B9] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
FBXW7 / FBW7 Antibody - IHC of paraffin-embedded Human bladder tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI10B9] (IgG2a) to Human FBXW7 / FBW7
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
FBXW7 / FBW7 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI4C11] (IgG2b) to Human FBXW7 / FBW7
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
FBXW7 / FBW7 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-FBXW7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI4C11] (IgG2b) to Human FBXW7 / FBW7
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
FBXW7 / FBW7 Antibody
Select
Rabbit Polyclonal to Human FBXW7 / FBW7
Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
Select
Rabbit Polyclonal (IgG) to Human FBXW7 / FBW7
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).