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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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ESRRA / ERR Alpha
estrogen-related receptor alpha
Estrogen-related receptor alpha (ERR alpha), a NR3 Steroid Receptor, was isolated based on sequence similarity in its DNA-binding domain to estrogen receptor alpha (ER alpha). ERR alpha has been shown to regulate the promoters of lactoferrin, medium-chain acyl CoA dehydrogenase, osteopontin, and thyroid receptor alpha, and it may affect cellular energy balance and bone formation. ERR alpha binds as a monodimer to the extended half-site TNAAGGTCA and as a homodimer to the estrogen response element (ERE) and is a constitutive activator of the estrogen response element and the palindromic thyroid hormone response element (TRE) but not of the glucocorticoid response element (GRE). ERR alpha 1 is the major isoform expressed in human breast cancer cell lines. Recent studies have shown that Phe-329 is responsible for the constitutive activity of ERR alpha. ERR alpha is a potential biomarker for unfavorable clinical outcome and, possibly, hormonal insensitivity in breast tumors. ERR alpha status may be predictive of sensitivity to hormonal blockade therapy, and ERR alpha status may also be predictive of ErbB2-based therapy such as Herceptin. Moreover, ERR alpha may be a candidate target for therapeutic development. ERRalpha null mice have altered regulation of genes involved in adipogenesis
Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha. Debevec D, Christian M, Morganstein D, Seth A, Herzog B, Parker M, White R. Molecular endocrinology (Baltimore, Md.). 2007 21:1581-92. (ChrIP; Mouse)[Full Text Article]
[PubMed:17456798]
[PMC:PMC2072047]
Related Antibodies: LS-A5402.
2
Expression of oestrogen-related receptor alpha in human epidermis. Bertil E, Bolzinger MA, Andr V, Rousselle P, Damour O. Experimental dermatology. 2008 17:208-13. (IHC-P; Human)
[PubMed:18070081]
Related Antibodies: LS-A5480.
3
Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression. Morganstein DL, Wu P, Mane MR, Fisk NM, White R, Parker MG. Cell Research. 2010 20:434-44. (ChrIP; Human)[Full Text Article]
[PubMed:20101261]
[PMC:PMC2848839]
Related Antibodies: LS-A5402.
4
Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle. Rinnankoski-Tuikka R, Silvennoinen M, Torvinen S, Hulmi JJ, Lehti M, Kivel R, Reunanen H, Kainulainen H. Nutrition & metabolism. 2012 9:53. (WB; Mouse)
[PubMed:22682013]
[PMC:PMC3407034]
5
High-fat feeding induces angiogenesis in skeletal muscle and activates angiogenic pathways in capillaries. Silvennoinen M, Rinnankoski-Tuikka R, Vuento M, Hulmi JJ, Torvinen S, Lehti M, Kivel R, Kainulainen H. Angiogenesis. 2013 16:297-307. (WB; Human)
[PubMed:23090645]
6
In vivo antral follicle wall biopsy: a new research technique to study ovarian function at the cellular and molecular levels. Ishak GM, Bashir ST, Dutra GA, Gastal GDA, Gastal MO, Cavinder CA, Feugang JM, Gastal EL. Reproductive biology and endocrinology : RB&E. 2018 July;16:71. [Full Text Article]
[PubMed:30055625]
[PMC:PMC6064614]
Related Antibodies: LS-A5402.
7
Transition to the ovulatory season in mares: An investigation of antral follicle receptor gene expression in vivo. Ghassan M A Ishak, Gabriel A Dutra, Gustavo D A Gastal, Melba O Gastal, Jean M Feugang, Eduardo L Gastal. Molecular reproduction and development. 2019 December;86:1832-1845. [Full Text Article]
[PubMed:31571308]
Related Antibodies: LS-A5402.
8
RIP140 expression is stimulated by estrogen-related receptor alpha during adipogenesis. Nichol D, Christian M, Steel JH, White R, Parker MG. The Journal of biological chemistry. 2006 Oct;281:32140-7. [Full Text Article]
[PubMed:16923809]
Related Antibodies: LS-A5402.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).