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| Catalog Number | Size | Price |
|---|---|---|
| LS-A5402-50 | 50 µg (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human ESRRA / ERR Alpha Antibody (Internal, IHC) LS‑A5402
PathPlus™ Polyclonal Rabbit anti‑Human ESRRA / ERR Alpha Antibody (Internal, IHC) LS‑A5402
Antibody:
ESRRA / ERR Alpha Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P, ChrIP
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig
Format:
Unconjugated, Unmodified
Overview
Antibody:
ESRRA / ERR Alpha Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P, ChrIP
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig
Format:
Unconjugated, Unmodified
Specifications
Description
Estrogen-related receptor alpha (ESRRA) regulates the promoters of lactoferrin, medium-chain acyl CoA dehydrogenase, osteopontin, and thyroid receptor alpha, and it may affect cellular energy balance and bone formation. ESRRA binds as a monodimer to the extended half-site TNAAGGTCA and as a homodimer to the estrogen response element (ERE). It is a constitutive activator of the estrogen response element and the palindromic thyroid hormone response element (TRE) but not of the glucocorticoid response element (GRE).
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human ESRRA / ERR Alpha
Synonyms
ESRRA | ERRa | ERR1 | HERR1 | NR3B1 | Steroid hormone receptor ERR1 | ERR-alpha | ERRalpha | ESRL1 | Estrogen receptor-like 1
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 15 amino acid peptide from internal region of human ESRRA. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Bat, Dog, Horse, Pig (100%); Gibbon (93%).
Epitope
Internal
Specificity
Human ESRRA. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (8 - 24 µg/ml)
- Chromatin Immunoprecipitation
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About ESRRA / ERR Alpha
Validation
Brain Hippocampus Neurons
Brain Hippocampus Neurons
Anti-ESRRA / ERR Alpha antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ESRRA / ERR Alpha antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ESRRA antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ESRRA antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ ESRRA / ERR Alpha Antibody (Internal) for IHC LS-A5402 has an LSBio Rating of
Publications (4.4)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (5)
Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha. Debevec D, Christian M, Morganstein D, Seth A, Herzog B, Parker M, White R. Molecular endocrinology (Baltimore, Md.). 2007 21:1581-92. (ChrIP; Mouse)
Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression. Morganstein DL, Wu P, Mane MR, Fisk NM, White R, Parker MG. Cell Research. 2010 20:434-44. (ChrIP; Human)
RIP140 expression is stimulated by estrogen-related receptor alpha during adipogenesis. Nichol D, Christian M, Steel JH, White R, Parker MG. The Journal of biological chemistry. 2006 Oct;281:32140-7.
In vivo antral follicle wall biopsy: a new research technique to study ovarian function at the cellular and molecular levels. Ishak GM, Bashir ST, Dutra GA, Gastal GDA, Gastal MO, Cavinder CA, Feugang JM, Gastal EL. Reproductive biology and endocrinology : RB&E. 2018 July;16:71.
Transition to the ovulatory season in mares: An investigation of antral follicle receptor gene expression in vivo. Ghassan M A Ishak, Gabriel A Dutra, Gustavo D A Gastal, Melba O Gastal, Jean M Feugang, Eduardo L Gastal. Molecular reproduction and development. 2019 December;86:1832-1845.
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig
Applications:
IHC, IHC - Paraffin
Species:
Human, Mouse, Rat
Applications:
IHC, Western blot, Immunoprecipitation
Source:
Human
Tag:
Myc-DDK (Flag)
Source:
E. coli
Tag:
GST, N-terminus
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/16/2024
Date Requested: 4/16/2024
