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EPCAM

epithelial cell adhesion molecule

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

Gene Name: epithelial cell adhesion molecule
Synonyms: EPCAM, 323/A3, ACSTD1, 17-1A, CD326, EGP, EGP34, Epithelial glycoprotein, GA733-2, HNPCC8, Ep-CAM, ESA, HEGP314, KS 1/4 antigen, KS1/4, KSA, M1S2, MIC18, MK-1, MH99, TROP1, TACST-1, TACSTD1, CD326 antigen, CO-17A, DIAR5, EGP-2, EGP314, EGP40, Epithelial glycoprotein 314, HEA125, Ly74, M4S1
Target Sequences: NM_002354 NP_002345.2 P16422

Publications (5)

1
Nuclear signalling by tumour-associated antigen EpCAM. Maetzel D, Denzel S, Mack B, Canis M, Went P, Benk M, Kieu C, Papior P, Baeuerle PA, Munz M, Gires O. Nature cell biology. 2009 11:162-71. (IP) [PubMed:19136966]
2
Both human and mouse mesenchymal stem cells promote breast cancer metastasis. Albarenque SM, Zwacka RM, Mohr A. Stem cell research. 2011 7:163-71. [PubMed:21763624]
3
An improved method for isolation of epithelial and stromal cells from the human endometrium. Masuda A, Katoh N, Nakabayashi K, Kato K, Sonoda K, Kitade M, Takeda S, Hata K, Tomikawa J. The Journal of reproduction and development. 2016 62:213-8. (Flo; Human) [Full Text Article] [PubMed:26853786] [PMC:PMC4848580] Related Antibodies: LS-C112552.
4
A role for intestinal TLR4-driven inflammatory response during activity-based anorexia. Belmonte L, Achamrah N, Nobis S, Guérin C, Riou G, Bôle-Feysot C, Boyer O, Richard V, Rego JC, Déchelotte P, Goichon A, Coëffier M. Scientific reports. 2016 October;6:35813. (Mouse) [Full Text Article] [PubMed:27779218] [PMC:PMC5078809]
5
Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs, DNMTs, and 5-hydroxymethylcytosine. Roulois D, Deshayes S, Guilly MN, Nader JS, Liddell C, Robard M, Hulin P, Ouacher A, Le Martelot V, Fonteneau JF, Grégoire M, Blanquart C, Pouliquen DL. Oncotarget. 2016 June;7:34664-87. (Human) [Full Text Article] [PubMed:27129173] [PMC:PMC5085183] Related Antibodies: LS-C331328.
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).