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In melanocytes, D-dopachrome tautomerase (DDT) converts D-dopachrome into 5, 6-dihydroxyindole. The amino acid sequence of DDT is 33% homologous with that of macrophage migration inhibitory factor (MIF) which has the potential to catalyze D-dopachrome to 5,6-dihydroxyindole-2-carboxylic acid and is an important cytokine for T-lymphocyte activation. Crystal structure studies have shown that DDT forms a homotrimer, while site-directed mutagenesis studies show that the N-terminal proline is important for enzymatic activity.
Gene Name: | D-dopachrome tautomerase |
Synonyms: | DDT, D-dopachrome decarboxylase, D-dopachrome tautomerase, DDCT, Phenylpyruvate tautomerase II |
Target Sequences: | NM_001355 NP_001346.1 P30046 |
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