DDB1

damage-specific DNA binding protein 1, 127kDa

Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2.

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Products

Antibodies (41)

Type

Primary (41)

Target

DDB1 (41)

Reactivity

Human (41)

Mouse (19)

Rat (14)

Bat (1)

Bovine (2)

Cat (1)

Dog (2)

Hamster (1)

Horse (2)

Monkey (3)

Pig (2)

Primate (1)

Rabbit (1)

Xenopus (1)

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Application

IHC (20)

IHC-P (12)

WB (35)

Flo (1)

DB (1)

ELISA (14)

ICC (2)

IF (2)

IP (9)

Peptide-ELISA (2)

Host

rabbit (27)

mouse (12)

goat (2)

Product Group

IHCPlus (5)

Isotype

IgG (20)

IgG1,k (6)

IgG2a (1)

IgG2a,k (1)

IgG2b (1)

Clonality

monoclonal mc (12)

polyclonal pc (29)

Clone

1322 (1)

4C5 (1)

Format

APC Conjugated (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Preservative Free (3)

Unconjugated (30)

Epitope

Internal (4)

C-Terminus (2)

aa1100-C-term (2)

aa1011-1140 (1)

aa1128-1140 (1)

aa198-213 (1)

aa385-435 (1)

aa749-1140 (1)

Publications

No (39)

Yes (2)

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IHC-plus™ DDB1 Antibody LS-B3138

(5.0) Rating

(1) Publication(s)

Antibody:

DDB1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$485

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DDB1 Antibody (HRP) LS-C545575

Antibody:

DDB1 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

HRP Conjugated

Price:

100 µl/$1,063

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DDB1 Antibody (APC) LS-C516346

Antibody:

DDB1 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

APC Conjugated

Price:

100 µl/$1,063

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DDB1 Antibody (PE) LS-C653654

Antibody:

DDB1 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

PE Conjugated

Price:

100 µl/$1,063

• Unconjugated
• HRP
• APC
• PE

• Unconjugated
• HRP
• APC
• More...
  • PE

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IHC-plus™ DDB1 Antibody (aa198-213) LS-B364

(5.0) Rating

(2) Publication(s)

Antibody:

DDB1 Rabbit anti-Human Polyclonal (aa198-213) Antibody

Reactivity:

Mouse, Human

Applications:

DB, ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$515

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IHC-plus™ DDB1 Antibody (C-Terminus, Preservative Free) LS-B1692

(4.0) Rating

Antibody:

DDB1 Rabbit anti-Human Polyclonal (C-Terminus) (Preservative Free) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated, Preservative Free

Price:

50 µg/$460

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IHC-plus™ DDB1 Antibody (clone 1322, Preservative Free) LS-B1691

(4.0) Rating

Antibody:

DDB1 Mouse anti-Human Monoclonal (Preservative Free) (1322) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated, Preservative Free

Price:

50 µl/$460

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IHC-plus™ DDB1 Antibody (aa1128-1140) LS-B11164

(4.0) Rating

Antibody:

DDB1 Goat anti-Human Polyclonal (aa1128-1140) Antibody

Reactivity:

Xenopus, Bat, Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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DDB1 Antibody (aa749-1140) LS-C185341

Antibody:

DDB1 Rabbit anti-Human Polyclonal (aa749-1140) Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$450

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DDB1 Antibody LS-C806492

Antibody:

DDB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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DDB1 Antibody (clone 4C5) LS-C133877

Antibody:

DDB1 Mouse anti-Human Monoclonal (4C5) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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DDB1 Antibody (aa1011-1140) LS-C407791

Antibody:

DDB1 Rabbit anti-Human Polyclonal (aa1011-1140) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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DDB1 Antibody LS-C490253

Antibody:

DDB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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DDB1 Antibody LS-C751732

Antibody:

DDB1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

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DDB1 Antibody LS-C332277

Antibody:

DDB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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DDB1 Antibody (Preservative Free) LS-C815289

Antibody:

DDB1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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DDB1 Antibody LS-C751731

Antibody:

DDB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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DDB1 Antibody LS-C402236

Antibody:

DDB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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DDB1 Antibody (aa1100-C-term) LS-C287347

Antibody:

DDB1 Rabbit anti-Human Polyclonal (aa1100-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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DDB1 Antibody LS-C671873

Antibody:

DDB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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DDB1 Antibody (Biotin) LS-C671877

Antibody:

DDB1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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DDB1 Antibody LS-C482385

Antibody:

DDB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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DDB1 Antibody LS-C341152

Antibody:

DDB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

DDB1 Antibody LS-C766000

Antibody:

DDB1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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DDB1 Antibody LS-C812938

Antibody:

DDB1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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