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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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DAPK1 / DAP Kinase

death-associated protein kinase 1

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca2+ influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition.Isoform 2 cannot induce apoptosis but can induce membrane blebbing.

Gene Name: death-associated protein kinase 1
Family/Subfamily: Protein Kinase , DAPK
Synonyms: DAPK1, DAP kinase 1, DAPK
Target Sequences: NM_004938 NP_004929.2 P53355

Publications (1)

1
DAPK1 as an independent prognostic marker in liver cancer. Li L, Guo L, Wang Q, Liu X, Zeng Y, Wen Q, Zhang S, Kwok HF, Lin Y, Liu J. PeerJ. 2017 July;5:e3568. (Human) [Full Text Article] [PubMed:28740751] [PMC:PMC5520959]


DAPK1 / DAP Kinase Antibody - Anti-DAPK1 / DAP Kinase antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50µl   1mg/ml   $425.00
DAPK1 / DAP Kinase Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Dog, Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
DAPK1 / DAP Kinase Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Dog, Guinea pig, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
DAPK1 / DAP Kinase Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Dog, Guinea pig, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $405.00
DAPK1 / DAP Kinase Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Dog, Guinea pig, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $405.00
DAPK1 / DAP Kinase Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Dog, Guinea pig, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $405.00
DAPK1 / DAP Kinase Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
Select
Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
IF, IHC, Peptide-ELISA
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
DAPK1 / DAP Kinase Antibody - Immunohistochemical analysis of DAP Kinase 1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human DAPK1 / DAP Kinase
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $275.00
DAPK1 / DAP Kinase Antibody - Mouse Dapk1 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The Dapk1 antibody detected the Dapk1 protein (arrow).
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Rabbit Polyclonal to Mouse DAPK1 / DAP Kinase
Mouse, Human
WB
Unconjugated
400µl   $325.00
DAPK1 / DAP Kinase Antibody - Western blot of DAPK1 antibody
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Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
ELISA, IF, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
DAPK1 / DAP Kinase Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using DAPK1 antibody.
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Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
ELISA, IF, IHC
Unconjugated
100µg   $305.00
Select
Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
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Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
DAPK1 / DAP Kinase Antibody - 1:100 staining mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal to Human DAPK1 / DAP Kinase
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   1mg/ml   $385.00
Select
Rabbit Polyclonal (IgG) to Mouse DAPK1 / DAP Kinase
Mouse, Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µl   $530.00
Select
Rabbit Polyclonal (IgG) to Human DAPK1 / DAP Kinase
Human
ELISA, WB
Unconjugated
100µg   $375.00
Viewing 1-25 of 36 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).