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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CYCS / Cytochrome c

cytochrome c, somatic

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Gene Name: cytochrome c, somatic
Synonyms: CYCS, CYC, HCS, THC4, Cytochrome c, Cytochrome c, somatic
Target Sequences: NM_018947 NP_061820.1 P99999

Publications (2)

1
Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease. She P, Zhang Z, Marchionini D, Diaz WC, Jetton TJ, Kimball SR, Vary TC, Lang CH, Lynch CJ. American journal of physiology. Endocrinology and metabolism. 2011 301:E49-61. [PubMed:21505144] [PMC:PMC3129844] Related Antibodies: LS-C41042.
2
Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species. McGuire KA, Barlan AU, Griffin TM, Wiethoff CM. Journal of virology. 2011 85:10806-13. [PubMed:21835790] [PMC:PMC3187480] Related Antibodies: LS-C41042.

Filtered by: None
Target
CYCS / Cytochrome c (165)
Reactivity
Human (141)
Mouse (106)
Rat (119)
Bovine (20)
Chicken (6)
Chimpanzee (4)
Dog (33)
Drosophila (25)
E. coli (6)
Frog (14)
Gibbon (4)
Goat (1)
Guinea pig (1)
Hamster (9)
Horse (49)
Monkey (8)
Orangutan (4)
Pig (17)
Pigeon (10)
Rabbit (23)
Sheep (7)
Xenopus (4)
Application
IHC (75)
IHC-Fr (6)
IHC-P (30)
WB (132)
Flo (38)
ELISA (45)
ICC (11)
ID (3)
IE (3)
IF (32)
IP (27)
Neut (1)
Peptide-ELISA (1)
Host
rabbit (74)
mouse (87)
sheep (4)
Isotype
IgG (37)
IgG1 (15)
IgG1,k (8)
IgG1b,k (7)
IgG2a (3)
IgG2a,k (17)
IgG2b (11)
IgG2b,k (21)
Clonality
monoclonal mc (87)
polyclonal pc (78)
Clone
2B5.F8 (1)
2F2 (1)
2G8 (1)
4B10 (1)
6H2 (2)
6H2.B4 (5)
7H8 (1)
7H8.2C12 (10)
7H8.2C12 + CYCS/1010 (3)
ABM30D4 (1)
CTC03 (3)
CTC05 (3)
CYC5420 (1)
CYCS/1010 (3)
SJL2-4 (1)
SPM389 (2)
Format
AP Conjugated (6)
APC (3)
APC Conjugated (8)
Azide-free (7)
Biotin Conjugated (18)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
DY488 Conjugated (1)
DY550 Conjugated (1)
FITC Conjugated (14)
HRP Conjugated (11)
Magnetic beads Conjugated (1)
PE Conjugated (9)
Ready-to-Use (3)
Sepharose Conjugated (1)
Unconjugated (89)
Epitope
aa13-99 (11)
aa5-100 (10)
aa1-80 (9)
aa10-59 (5)
aa91-105 (5)
aa2-105 (2)
aa66-104 (2)
10-90 aa, N-terminal (1)
C-Terminus (1)
His19 (1)
N-Terminus (1)
aa1-188 (1)
aa21-55 (1)
aa55-105 (1)
Publications
No (164)
Yes (1)
Showing 1-25 of 165 results

CYCS / Cytochrome c Antibody (aa1-80, clone 7H8.2C12) IHC-plus™ LS-B2141
Mouse Monoclonal [clone 7H8.2C12] (IgG2b) to Pigeon CYCS / Cytochrome c
Pigeon, Drosophila, Horse, Mouse, Rat, Hamster, Human
ICC IHC IHC-P WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-Cytochrome c antibody IHC of human bone marrow. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Western blot detection of Cytochrome C in 15 ugs of HeLa cell lysate using antibody at 1:1000. A 15 kD band is detected.

CYCS / Cytochrome c Antibody (clone 7H8.2C12) IHC-plus™ LS-B3673
Mouse Monoclonal [clone 7H8.2C12] (IgG2b) to Horse CYCS / Cytochrome c
Rabbit, Mouse, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-Cytochrome c antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-Cytochrome c antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

CYCS / Cytochrome c Antibody (clone 6H2.B4) LS-C41042
Publications (2)
Publications (2)
Mouse Monoclonal [clone 6H2.B4] (IgG1) to Mouse CYCS / Cytochrome c
Mouse, Rat, Human
Flo IF IP WB
Unconjugated
100µg 0.5mg/ml  $275.00
Cytochrome c was immunoprecipitated from Hela cell extract (1% NP-40) using 2-4 ug 6H2. B4 antibody/1 x107 cell equivalents. Immunoprecipitates were resolved by electrophoresis, transferred to nitrocellulose, and probed with the 7H8.2C12 anti-cytochrome c antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system. In addition to the specific 15 kD cytochrome c band immunoprecipitated by 6H2. B4, heavy and light immunoglobulin chains are recognized by the goat anti-mouse secondary antibody.

CYCS / Cytochrome c Antibody (clone 7H8.2C12) IHC-plus™ LS-B1682
Mouse Monoclonal [clone 7H8.2C12] (IgG2a) to Horse CYCS / Cytochrome c
Horse, Human
IHC IHC-P WB
Unconjugated
50µl  $425.00
Anti-Cytochrome c antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with anti-cytochrome C (clone 7H8.2C12) antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system.

CYCS / Cytochrome c Antibody (clone 7H8) IHC-plus™ LS-B7872
Mouse Monoclonal [clone 7H8] (IgG2b,k) to Human CYCS / Cytochrome c
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-Cytochrome c antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Anti-Cytochrome c antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

CYCS / Cytochrome c Antibody (clone 2B5.F8) LS-C63083
Mouse Monoclonal [clone 2B5.F8] (IgG2a) to Horse CYCS / Cytochrome c
Dog, Bovine, Horse, Human
IP
Unconjugated
100µg 1mg/ml  $365.00

CYCS / Cytochrome c Antibody LS-C147400
Rabbit Polyclonal to Horse CYCS / Cytochrome c
Horse
ELISA IF IHC WB
Unconjugated
1mg  $475.00

CYCS / Cytochrome c Antibody LS-C36088
Mouse Monoclonal (IgG1b,k) to Human CYCS / Cytochrome c
Mouse, Rat, Human
ELISA IF IP
Unconjugated
100µg  $605.00

CYCS / Cytochrome c Antibody (clone CTC03) LS-C87654
Mouse Monoclonal [clone CTC03] (IgG2a,k) to Horse CYCS / Cytochrome c
Dog, Bovine, Horse, Human
ELISA Flo IP
Unconjugated
100µl  $285.00; 500µl  $560.00; 1ml  $805.00

CYCS / Cytochrome c Antibody LS-C36090
Sheep Polyclonal (IgG) to Human CYCS / Cytochrome c
Mouse, Dog, Rat, Human
IF IP WB
Unconjugated
100µg  $560.00

CYCS / Cytochrome c Antibody (N-Terminus) LS-C353488
Rabbit Polyclonal to Human CYCS / Cytochrome c
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Human
IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of Cytochrome c staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of Cytochrome c expression in HeLa (A); Jurkat (B); L929 (C); NIH3T3 (D); MCF7 (E); mouse kidney (F); rat heart (G) whole cell lysates.

CYCS / Cytochrome c Antibody (clone CYCS/1010) LS-C390839
Mouse Monoclonal [clone CYCS/1010] (IgG2b,k) to Human CYCS / Cytochrome c
Rat, Human
Flo IF IHC IHC-P WB
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00
Formalin-fixed, paraffin-embedded human heart stained with Cytochrome C antibody (CYCS/1010).
Formalin-fixed, paraffin-embedded human pancreas stained with Cytochrome C antibody (CYCS/1010).

CYCS / Cytochrome c Antibody (clone CYCS/1010) LS-C390841
Mouse Monoclonal [clone CYCS/1010] (IgG2b,k) to Human CYCS / Cytochrome c
Rat, Human
Flo IF IHC IHC-P WB
Unconjugated
100µg 1mg/ml  $465.00
Formalin-fixed, paraffin-embedded human heart stained with Cytochrome C antibody (CYCS/1010).
Formalin-fixed, paraffin-embedded human pancreas stained with Cytochrome C antibody (CYCS/1010).

CYCS / Cytochrome c Antibody (aa1-80, clone 7H8.2C12) LS-C390828
Mouse Monoclonal [clone 7H8.2C12] (IgG2b,k) to Pig CYCS / Cytochrome c
Drosophila, Pig, Horse, Mouse, Dog, Rat, Human
Flo IF IHC IHC-P WB
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00
Formalin-fixed, paraffin-embedded human salivary tumor stained with Cytochrome C antibody (7H8.2C12).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human pancreas stained with Cytochrome C antibody (7H8.2C12).  This image was taken for the unmodified form of this product. Other forms have not been tested.

CYCS / Cytochrome c Antibody (aa1-80, clone 7H8.2C12, Azide-free) LS-C390830
Mouse Monoclonal [clone 7H8.2C12] (IgG2b,k) to Pig CYCS / Cytochrome c
Drosophila, Pig, Horse, Mouse, Dog, Rat, Human
Flo IF IHC IHC-P WB
Unconjugated, Azide-free
100µg 1mg/ml  $465.00
Formalin-fixed, paraffin-embedded human salivary tumor stained with Cytochrome C antibody (7H8.2C12).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human pancreas stained with Cytochrome C antibody (7H8.2C12).  This image was taken for the unmodified form of this product. Other forms have not been tested.

CYCS / Cytochrome c Antibody (clone 6H2, FITC) LS-C105908
Mouse Monoclonal [clone 6H2] (IgG1,k) to Human CYCS / Cytochrome c
Mouse, Rat, Human
Flo
FITC Conjugated
100µg 0.5mg/ml  $335.00
Intracellular staining of HeLa cells with anti-Cytochrome c (6H2) FITC. Appropriate isotype controls were used (open histogram). Total cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CYCS / Cytochrome c Antibody LS-C357834
Rabbit Polyclonal (IgG) to Human CYCS / Cytochrome c
Mouse, Rat, Human
ICC IHC IHC-P WB
Unconjugated
100µg  $435.00
IHC-P: Cytochrome C antibody testing of human intestinal cancer tissue
IHC-P Cytochrome C antibody testing of mouse brain tissue

CYCS / Cytochrome c Antibody (clone CTC05) LS-C390838
Mouse Monoclonal [clone CTC05] (IgG2b,k) to Human CYCS / Cytochrome c
Drosophila, Horse, Mouse, Dog, Rat, Human
Flo IF IHC IHC-P WB
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00
Formalin-fixed, paraffin-embedded human heart stained with Cytochrome C antibody (CTC05).  This image was taken for the unmodified form of this product. Other forms have not been tested.

CYCS / Cytochrome c Antibody (clone CTC05, Azide-free) LS-C390837
Mouse Monoclonal [clone CTC05] (IgG2b,k) to Human CYCS / Cytochrome c
Drosophila, Horse, Mouse, Dog, Rat, Human
Flo IF IHC IHC-P WB
Unconjugated, Azide-free
100µg 1mg/ml  $465.00
Formalin-fixed, paraffin-embedded human heart stained with Cytochrome C antibody (CTC05).  This image was taken for the unmodified form of this product. Other forms have not been tested.

CYCS / Cytochrome c Antibody (clone CTC05, Ready-to-Use) LS-C390840
Mouse Monoclonal [clone CTC05] (IgG2b,k) to Human CYCS / Cytochrome c
Drosophila, Horse, Mouse, Dog, Rat, Human
Flo IF IHC IHC-P WB
Unconjugated, Ready-to-Use
7ml  $465.00
Formalin-fixed, paraffin-embedded human heart stained with Cytochrome C antibody (CTC05).  This image was taken for the unmodified form of this product. Other forms have not been tested.

CYCS / Cytochrome c Antibody (aa2-105) LS-C357520
Rabbit Polyclonal to Human CYCS / Cytochrome c
Mouse, Rat, Human
ICC IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $325.00
Cytochrome C antibody IHC-paraffin: Mouse Brain Tissue.
Cytochrome C antibody IHC-paraffin: Rat Brain Tissue.

CYCS / Cytochrome c Antibody LS-C48137
Mouse Monoclonal (IgG2b) to Pig CYCS / Cytochrome c
Mouse, Rat, Pig, Human
WB
Unconjugated
100µg 500µl 0.2mg/ml  $545.00
Western blot of Cytochrome c antibody.

CYCS / Cytochrome c Antibody (aa91-105) LS-C357837
Rabbit Polyclonal (IgG) to Human CYCS / Cytochrome c
Rabbit, Mouse, Rat, Hamster, Chimpanzee, Orangutan, Gibbon, Human, Monkey
ICC IHC IHC-Fr IHC-P WB
Unconjugated
100µg  $435.00
IHC-P: Cytochrome C antibody testing of rat lung tissue
IHC-F testing of Cytochrome C antibody and rat brain tissue

CYCS / Cytochrome c Antibody (aa1-80, clone 7H8.2C12 + CYCS/1010) LS-C390844
Mouse Monoclonal [clone 7H8.2C12 + CYCS/1010] (IgG) to Pig CYCS / Cytochrome c
Rat, Pig, Human
Flo IF IHC IHC-P WB
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00
Formalin-fixed, paraffin-embedded human heart stained with Cytochrome C antibody (7H8.2C12 + CYCS/1010).  This image was taken for the unmodified form of this product. Other forms have not been tested.

CYCS / Cytochrome c Antibody (aa1-80, clone 7H8.2C12 + CYCS/1010, Azide-free) LS-C390846
Mouse Monoclonal [clone 7H8.2C12 + CYCS/1010] (IgG) to Pig CYCS / Cytochrome c
Rat, Pig, Human
Flo IF IHC IHC-P WB
Unconjugated, Azide-free
100µg 1mg/ml  $465.00
Formalin-fixed, paraffin-embedded human heart stained with Cytochrome C antibody (7H8.2C12 + CYCS/1010).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Showing 1-25 of 165 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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