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Cullin 4A / CUL4A

cullin 4A

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.

Gene Name: cullin 4A
Synonyms: CUL4A, CUL-4A, Cullin-4A, Cullin 4A
Target Sequences: NM_003589 NP_003580.1 Q13619

Publications (3)

1
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM. Cell. 1996 85:829-39. [PubMed:8681378] Related Antibodies: LS-B360.
2
Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Higa LA, Mihaylov IS, Banks DP, Zheng J, Zhang H. Nature cell biology. 2003 5:1008-15. [PubMed:14578910] Related Antibodies: LS-B360.
3
Importance of Cullin4 Ubiquitin Ligase in Malignant Pleural Mesothelioma. Mayura Meerang, Jessica Kreienbühl, Vanessa Orlowski, Seraina L C Müller, Michaela B Kirschner, Isabelle Opitz. Cancers. 2020 November;12: [Full Text Article] [PubMed:33233664] [PMC:PMC7699720] Related Antibodies: LS-B360.

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Antibodies (37)
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Cullin 4A / CUL4A (37)
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Cullin 4A / CUL4A Antibody - Anti-CUL4A / Cullin 4A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa1-25) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$495
Cullin 4A / CUL4A Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa630-679) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Cullin 4A / CUL4A Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa630-679) (HRP) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
Cullin 4A / CUL4A Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa630-679) (Biotin) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
Cullin 4A / CUL4A Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa630-679) (FITC) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
Cullin 4A / CUL4A Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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Cullin 4A / CUL4A Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$371
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
Cullin 4A / CUL4A Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa102-131) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
Cullin 4A / CUL4A Antibody - Detection of Human and Mouse Cul4a by Immunohistochemistry. Sample: FFPE section of human breast carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-Cul4a used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa700-C-term) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Cullin 4A / CUL4A Antibody - Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue  using CUL4A Polyclonal Antibody at dilution of 1:55(×200)
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa1-20) Antibody
Human
ELISA, ICC, WB
Unconjugated
1 mg/$901
Cullin 4A / CUL4A Antibody - Immunofluorescent analysis of HepG2 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$331
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
Cullin 4A / CUL4A Antibody - Detection of Human Cul4a by Immunohistochemistry. Sample: FFPE section of human breast tumor. Antibody: Affinity purified rabbit anti-Cul4a used at a dilution of 1:500.
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa700-C-term) Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
1 µg/$295; 100 µl/$532
Cullin 4A / CUL4A Antibody - Western blot - Anti-Cullin 4a Picoband antibody
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
10 µg/$318; 100 µg/$470
Cullin 4A / CUL4A Antibody - Western blot analysis of CUL4A expression in HeLa cells lysate. The lane on the left is treated with the antigen-specific peptide.
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Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).