Cullin 4A / CUL4A

cullin 4A

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.

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Antibodies (37)

Proteins (7)

Type

Over-Expression Lysate (4)

Primary (37)

Recombinant (3)

Target

Cullin 4A / CUL4A (44)

Reactivity

Human (37)

Mouse (24)

Rat (4)

Bat (3)

Bovine (3)

Chimpanzee (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Pig (3)

Rabbit (3)

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Application

IHC (14)

IHC-P (9)

WB (30)

ELISA (19)

ICC (1)

IF (4)

IP (3)

Peptide-ELISA (1)

Host

rabbit (35)

mouse (2)

Product Group

IHCPlus (4)

Isotype

IgG (24)

IgG1 (1)

IgG2b,k (1)

Clonality

monoclonal mc (2)

polyclonal pc (35)

Clone

3H3 (1)

Format

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Unconjugated (21)

Epitope

aa31-60 (7)

aa630-679 (4)

aa700-C-term (2)

aa1-20 (1)

aa1-25 (1)

aa102-131 (1)

Publications

No (43)

Yes (1)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (5)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ Cullin 4A / CUL4A Antibody (aa1-25) LS-B360

(5.0) Rating

(3) Publication(s)

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa1-25) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$495

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Cullin 4A / CUL4A Antibody (aa630-679) LS-B12021

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa630-679) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

Cullin 4A / CUL4A Antibody (aa630-679, HRP) LS-C468894

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa630-679) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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Cullin 4A / CUL4A Antibody (aa630-679, Biotin) LS-C468893

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa630-679) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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Cullin 4A / CUL4A Antibody (aa630-679, FITC) LS-C468892

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa630-679) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

IHC-plus™ Cullin 4A / CUL4A Antibody LS-B12903

(4.0) Rating

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

Cullin 4A / CUL4A Antibody LS-C664867

Antibody:

Cullin 4A / CUL4A Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$371

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Cullin 4A / CUL4A Antibody LS-C755114

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

IHC-plus™ Cullin 4A / CUL4A Antibody (aa102-131) LS-B11715

(4.0) Rating

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa102-131) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

Select

Cullin 4A / CUL4A Antibody (aa700-C-term) LS-C287603

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa700-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

Cullin 4A / CUL4A Antibody LS-C831031

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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Cullin 4A / CUL4A Antibody (aa1-20) LS-C90301

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa1-20) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

1 mg/$901

Select

Cullin 4A / CUL4A Antibody LS-C664866

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$331

Select

Cullin 4A / CUL4A Antibody LS-C677614

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

Cullin 4A / CUL4A Antibody LS-C341497

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

Cullin 4A / CUL4A Antibody (aa31-60) LS-C320688

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

Cullin 4A / CUL4A Antibody (aa31-60, Biotin) LS-C221954

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

Cullin 4A / CUL4A Antibody (aa31-60, FITC) LS-C221955

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

Cullin 4A / CUL4A Antibody (aa31-60, APC) LS-C221953

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

Cullin 4A / CUL4A Antibody (aa31-60, PE) LS-C221957

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

Cullin 4A / CUL4A Antibody (aa31-60, Azide-free, HRP) LS-C221956

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa31-60) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

Cullin 4A / CUL4A Antibody LS-C781460

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

Cullin 4A / CUL4A Antibody (aa700-C-term) LS-C286415

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal (aa700-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

1 µg/$295; 100 µl/$532

Select

Cullin 4A / CUL4A Antibody LS-C662548

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

Cullin 4A / CUL4A Antibody LS-C809145

Antibody:

Cullin 4A / CUL4A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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