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CTNNB1 / Beta Catenin

catenin (cadherin-associated protein), beta 1, 88kDa

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.

Gene Name: catenin (cadherin-associated protein), beta 1, 88kDa
Family/Subfamily: Catenin , not assigned-Catenin
Synonyms: CTNNB1, Beta-catenin, Catenin beta-1, CTNNB, Beta Catenin
Target Sequences: NM_001904 NP_001895.1 P35222

Publications (7)

1
Wnt pathway-related gene expression during malignant progression in ulcerative colitis. van Dekken H, Wink JC, Vissers KJ, Franken PF, Ruud Schouten W, J Hop WC, Kuipers EJ, Fodde R, Janneke van der Woude C. Acta histochemica. 2007 109:266-72. (IHC) [PubMed:17445872]
2
Pro-metastatic intracellular signaling of the elaidic trans fatty acid. Fujii K, Luo Y, Fujiwara-Tani R, Kishi S, He S, Yang S, Sasaki T, Ohmori H, Kuniyasu H. International journal of oncology. 2017 50:85-92. (WB; Human) [Full Text Article] [PubMed:27959384]
3
Nitric Oxide Mediates Crosstalk between Interleukin 1ß and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression. Zhong L, Schivo S, Huang X, Leijten J, Karperien M, Post JN. International journal of molecular sciences. 2017 November;18:pii: E2491. (Human) [Full Text Article] [PubMed:29165387] [PMC:PMC5713457] Related Antibodies: LS-C203657.
4
Inhibition of Stress-Induced Viral Promoters by a Bovine Herpesvirus 1 Non-Coding RNA and the Cellular Transcription Factor, ß-Catenin. Jing Zhao, Nishani Wijesekera, Clinton Jones. International journal of molecular sciences. 2021 January;22: [Full Text Article] [PubMed:33430186] [PMC:PMC7825607] Related Antibodies: LS-C21245.
5
Bioengineered Tooth Buds Exhibit Features of Natural Tooth Buds. E E Smith, S Angstadt, N Monteiro, W Zhang, A Khademhosseini, P C Yelick. Journal of dairy science. 2018 September;97:1144-1151. [Full Text Article] [PubMed:29879370] [PMC:PMC6169029] Related Antibodies: LS-C172582.
6
An ARC-Regulated IL1ß/Cox-2/PGE2/ß-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML. Bing Z Carter, Po Yee Mak, Xiangmeng Wang, Wenjing Tao, Vivian Ruvolo, Duncan Mak, Hong Mu, Jared K Burks, Michael Andreeff. Cancer research. 2019 Mar;79:1165-1177. [Full Text Article] [PubMed:30674535] [PMC:PMC6420856] Related Antibodies: LS-B4123.
7
Herpes simplex virus 1 regulates ß-catenin expression in TG neurons during the latency-reactivation cycle. Kelly S Harrison, Liqian Zhu, Prasanth Thunuguntla, Clinton Jones. PloS one. 2020 Mar;15:e0230870. [Full Text Article] [PubMed:32226020] [PMC:PMC7105109]
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CTNNB1 / Beta Catenin Antibody - Anti-CTNNB1 / Beta Catenin antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (4D5) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CTNNB1 / Beta Catenin Antibody - Anti-CTNNB1 / Beta Catenin antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Cancer Pathology
Cancer
CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (EM-22) Antibody
Mouse, Hamster, Human
Flo, ICC, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$440
CTNNB1 / Beta Catenin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$809
CTNNB1 / Beta Catenin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$835
CTNNB1 / Beta Catenin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$792
CTNNB1 / Beta Catenin Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 20 ug/ml.
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CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (OTI1E10) Antibody
Dog, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$409
CTNNB1 / Beta Catenin Antibody - CTNB1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (aa646-673) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$381
CTNNB1 / Beta Catenin Antibody - Anti-CTNNB1 / Beta Catenin antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (aa43-62) Antibody
Mouse, Rat, Hamster, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$460
CTNNB1 / Beta Catenin Antibody - Immunohistochemical analysis of Beta-catenin (pS37) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (pSer37) Antibody
Zebrafish, Pig, Rat, Rabbit, Mouse, Dog, Sheep, Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$305
CTNNB1 / Beta Catenin Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (aa78-106) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
CTNNB1 / Beta Catenin Antibody - Anti-CTNNB1 / Beta Catenin antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (aa758-771) Antibody
Human
ICC, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$485
CTNNB1 / Beta Catenin Antibody - Western blot of Phospho-Catenin-beta (S552) antibody
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CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (490-570 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
CTNNB1 / Beta Catenin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
CTNNB1 / Beta Catenin Rabbit anti-Human Recombinant Monoclonal (CTNNB1/2030R) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
100 µg/$495
CTNNB1 / Beta Catenin Antibody - Immunohistochemical analysis of Beta-catenin staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Pig, Mouse, Bovine, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$289
CTNNB1 / Beta Catenin Antibody - Immunofluorescence of monoclonal antibody to CTNNB1 on HeLa cell. [antibody concentration 10 ug/ml]
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CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal (1C9) Antibody
Human
ELISA, IF, RNAi, WB
Unconjugated
100 µg/$413
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CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (aa29-49) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Mouse, Dog, Rat, Hamster, Human, Monkey
ICC, IP, WB
Unconjugated
200 µg/$802
CTNNB1 / Beta Catenin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$653
CTNNB1 / Beta Catenin Antibody - Western blot of Phospho-Catenin-beta (Y654) antibody
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CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (590-670 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
CTNNB1 / Beta Catenin Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
CTNNB1 / Beta Catenin Mouse anti-Human Recombinant Monoclonal (rCTNNB1/2173) Antibody
Human
IF, IHC-P, WB
Unconjugated
100 µg/$495
CTNNB1 / Beta Catenin Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
CTNNB1 / Beta Catenin Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
CTNNB1 / Beta Catenin Antibody - CTNNB1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (aa692-721) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$376
CTNNB1 / Beta Catenin Antibody - Immunohistochemistry-Paraffin: beta-Catenin Antibody (12F7) - IHC analysis of beta- Catenin in mouse intestine using DAB with hematoxylin counterstain.
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CTNNB1 / Beta Catenin Mouse anti-Chicken Monoclonal (12F7) Antibody
Chicken, Rat, Mouse, Primate, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$376
CTNNB1 / Beta Catenin Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
CTNNB1 / Beta Catenin Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
120 µl/$460
CTNNB1 / Beta Catenin Antibody - Immunohistochemical analysis of Beta-catenin (pS33) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (pSer33) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$305
CTNNB1 / Beta Catenin Antibody - Western blot analysis of extracts from MCF-7 cells.
Select
CTNNB1 / Beta Catenin Rabbit anti-Human Polyclonal (pSer33) Antibody
WB
Unconjugated
50 µl/$306; 100 µl/$381; 200 µl/$489
Viewing 1-25 of 459 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).