CLU / Clusterin

clusterin

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

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Products

Proteins (29)

Type

Over-Expression Lysate (4)

Recombinant (25)

Target

CLU / Clusterin (29)

Application

SDS-PAGE (1)

Publications

No (29)

Tag

10His-SUMO, N-terminus + Myc, C-terminus (1)

6His, C-terminus (4)

DDK (Flag) (1)

Fc/6His,C-terminus (1)

Fc-6His, C-terminus (1)

GST, N-terminus (1)

His (10)

His,C-terminus (1)

His-S (1)

His-T7 (2)

Myc-DDK (Flag) (6)

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Species

Bovine (1)

Dog (1)

Human (15)

Mouse (6)

Pig (1)

Rabbit (1)

Rat (1)

Sheep (1)

Source

293T Cells (2)

E. coli (12)

HEK 293 Cells (6)

Human Cells (5)

Mammalian Cells (3)

Wheat Germ Extract (1)

Purification

Purified (10)

Low Endotoxin Level

Low endotoxin level (12)

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Dog CLU / Clusterin Protein (Recombinant His-S) (aa227-445) - LS-G13430

Source:

E. coli

Tag:

His-S

Molecular Weight:

31.0 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human CLU / Clusterin Protein (Recombinant His) (aa228-449) - LS-G13429

Source:

E. coli

Tag:

His

Molecular Weight:

27.1 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Rat CLU / Clusterin Protein (Recombinant His) (aa227-447) - LS-G13441

Source:

E. coli

Tag:

His

Molecular Weight:

26.7 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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CLU / Clusterin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129859

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.1 kDa

Price:

100 µg/$494

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Human CLU / Clusterin Protein (Recombinant 6His, C-terminus) (Asp23-Glu449) - LS-G138941

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

51.1 kDa

Price:

10 µg/$269; 50 µg/$368

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Human CLU / Clusterin Protein (Recombinant Fc/6His,C-terminus) (Asp23-Glu449) - LS-G139060

Source:

Mammalian Cells

Tag:

Fc/6His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

78.0 kDa

Price:

10 µg/$281; 50 µg/$389

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Sheep CLU / Clusterin Protein (Recombinant His-T7) (aa20-439) - LS-G24229

Source:

E. coli

Tag:

His-T7

Molecular Weight:

52.6 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human CLU / Clusterin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75210

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50 kDa

Price:

20 µg/$150

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Human CLU / Clusterin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75208

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.1 kDa

Price:

20 µg/$150

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Mouse CLU / Clusterin Protein (Recombinant His,C-terminus) (Met1-Glu448) - LS-G49309

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The full length of recombinant mouse CLU comprises 438 amino acids and has a calculated molecular mass of 50.8 kDa. The apparent molecular mass of the recombinant protein is approximately 32, 42 and 65 kDa in SDS-PAGE under reducing conditions, corresponding to the cleaved ß chain, a chain and the full length respectively.

Price:

50 µg/$348; 100 µg/$441; 1 mg/$2,003

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Human CLU / Clusterin Protein (Recombinant GST, N-terminus) (aa402-501) - LS-G58153

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CLU / Clusterin Protein (Recombinant DDK (Flag)) (aa1-449) - LS-G55649

Source:

HEK 293 Cells

Tag:

DDK (Flag)

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Molecular Weight:

80kDa (under non-reducing conditions); 39kDa and 40kDa (under reducing conditions, SDS -PAGE).

Price:

10 µg/$323; 50 µg/$431

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Human CLU / Clusterin Protein (Recombinant His) (Met1-Glu501) - LS-G97067

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

51.5 kDa

Price:

50 µg/$483

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Mouse CLU / Clusterin Protein (Recombinant His) (Met1-Glu448) - LS-G97068

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

50.8 kDa

Price:

50 µg/$483; 100 µg/$721

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Human CLU / Clusterin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65269

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.7 kDa

Price:

20 µg/$1,107

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Human CLU / Clusterin Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65270

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50 kDa

Price:

20 µg/$1,107

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CLU / Clusterin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103174

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50 kDa

Price:

100 µg/$494

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Mouse CLU / Clusterin Protein (Recombinant His) (aa22-448) - LS-G3769

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~45kDa (SDS-PAGE)

Price:

50 µg/$431

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Human CLU / Clusterin Protein (Recombinant His) (aa23-449) - LS-G3756

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~45kDa (SDS-PAGE)

Price:

50 µg/$431

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Mouse CLU / Clusterin Protein (Recombinant 6His, C-terminus) (Glu22-Glu448) - LS-G139302

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

50.4 kDa

Price:

10 µg/$281; 50 µg/$389

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Human CLU / Clusterin Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (aa23-449) - LS-G56172

Source:

E. coli

Tag:

10His-SUMO, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human CLU / Clusterin Protein (Recombinant His) - LS-G2792

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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Mouse CLU / Clusterin Protein (Recombinant 6His, C-terminus) (Glu22-Glu448) - LS-G39883

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

50.4kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human CLU / Clusterin Protein (Recombinant Fc-6His, C-terminus) (Asp23-Glu449) - LS-G39470

Source:

Human Cells

Tag:

Fc-6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

78kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human CLU / Clusterin Protein (Recombinant 6His, C-terminus) (Asp23-Glu449) - LS-G38963

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

51.1kD

Price:

10 µg/$269; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157

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