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CDK12 / CRKRS

cyclin-dependent kinase 12

Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Gene Name: cyclin-dependent kinase 12
Family/Subfamily: Protein Kinase , CDC2/CDK
Synonyms: CDK12, CDC2-related protein kinase 7, CRK7, Cyclin-dependent kinase 12, HCDK12, KIAA0904, CRKR, CRKRS, Pksc
Target Sequences: NM_016507 NP_057591.2 Q9NYV4

Publications (1)

1
HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation. Nur Firdaus Isa , Olivier Bensaude, Nadiah C Aziz, Shona Murphy. Vaccines. 2021 Sep;9:1054. [Full Text Article] [PubMed:34696162] [PMC:PMC8539892] Related Antibodies: LS-C288466.

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Antibodies (17)
Primary (17)
CDK12 / CRKRS (17)
Human (17)
Mouse (8)
Rat (3)
Dog (1)
Monkey (1)
IHC (1)
IHC-P (1)
WB (13)
ELISA (9)
IP (1)
Peptide-ELISA (1)
rabbit (16)
mouse (1)
Product Group
Alzheimer's Disease (17)
PathPlus Neuro (1)
IgG (13)
IgG2a,k (1)
monoclonal mc (1)
polyclonal pc (16)
3C1 (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (9)
aa1-30 (7)
Internal (1)
aa1-50 (1)
No (16)
Yes (1)
CDK12 / CRKRS Antibody - Anti-CDK12 / CRKRS antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (Internal) Antibody
Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
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CDK12 / CRKRS Mouse anti-Human Monoclonal (3C1) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
CDK12 / CRKRS Antibody - The anti-CRK7 antibody is used in Western blot to detect CRK7 in mouse liver tissue lysate.
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
CDK12 / CRKRS Antibody - Positive Western Blot detected in Hela whole cell lysate, K562 whole cell lysate. All lanes: CDK12 antibody at 2 µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 165, 164, 142 KDa. Observed band size: 165 KDa
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CDK12 / CRKRS Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
CDK12 / CRKRS Antibody - Western blot analysis of extracts of various cell lines, using CDK12 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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CDK12 / CRKRS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
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CDK12 / CRKRS Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
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CDK12 / CRKRS Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
CDK12 / CRKRS Antibody - Western blot analysis of CD2L7 using HuvEc whole cells lysates
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CDK12 / CRKRS Rabbit anti-Human Polyclonal Antibody
Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).