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Catalog Number Size Price
LS-A7350-50 50 µg (1 mg/ml) $460 
CDK12 / CRKRS Antibody - Breast, Carcinoma
CDK12 / CRKRS Antibody - Prostate, cancer
CDK12 / CRKRS Antibody - Brain, Substantia Nigra, nonpigmented neurons
CDK12 / CRKRS Antibody - Anti-CDK12 / CRKRS antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CDK12 / CRKRS Antibody - Anti-CDK12 / CRKRS antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CDK12 / CRKRS Antibody - Anti-CDK12 / CRKRS antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CDK12 / CRKRS Antibody - Breast, Carcinoma
CDK12 / CRKRS Antibody - Prostate, cancer
CDK12 / CRKRS Antibody - Brain, Substantia Nigra, nonpigmented neurons
CDK12 / CRKRS Antibody - Anti-CDK12 / CRKRS antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CDK12 / CRKRS Antibody - Anti-CDK12 / CRKRS antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CDK12 / CRKRS Antibody - Anti-CDK12 / CRKRS antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human CDK12 / CRKRS Antibody (Internal, IHC) LS‑A7350

PathPlus™ Polyclonal Rabbit anti‑Human CDK12 / CRKRS Antibody (Internal, IHC) LS‑A7350

Antibody:
CDK12 / CRKRS Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Dog
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A7350-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
CDK12 / CRKRS Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Dog
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Cyclin-dependent kinase 12 (CDK12) phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. CDK12 regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. It preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. CDK12 is required for RNA splicing, possibly by phosphorylating SRSF1/SF2 and is involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human CDK12 / CRKRS
Synonyms
CDK12 | CDC2-related protein kinase 7 | CRK7 | Cyclin-dependent kinase 12 | HCDK12 | KIAA0904 | CRKR | CRKRS | Pksc
Host
Rabbit
Reactivity
Human, Monkey, Dog (tested or 100% immunogen sequence identity)
Predicted
Rat, Bat, Bovine, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from internal region of human CDK12 / CRKRS. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Panda, Dog (100%); Elephant, Bovine, Rabbit (95%); Rat, Bat (90%); Mouse, Hamster, Horse (85%).
Epitope
Internal
Specificity
Human CDK12 / CRKRS. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except AKAP12 (55%).
Applications
  • IHC
  • IHC - Paraffin (6 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CDK12 / CRKRS
Q9NYV4 NM_016507 NP_057591.2

Validation

CDK12 / CRKRS Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

CDK12 / CRKRS Antibody - Prostate, cancer
Prostate, cancer
Prostate, cancer

CDK12 / CRKRS Antibody - Brain, Substantia Nigra, nonpigmented neurons
Brain, Substantia Nigra, nonpigmented neurons
Brain, Substantia Nigra, nonpigmented neurons

CDK12 / CRKRS Antibody - Anti-CDK12 / CRKRS antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CDK12 / CRKRS Antibody - Anti-CDK12 / CRKRS antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CDK12 / CRKRS Antibody - Anti-CDK12 / CRKRS antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ CDK12 / CRKRS Antibody (Internal) for IHC LS-A7350 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/17/2021