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| Catalog Number | Size | Price |
|---|---|---|
| LS-A7350-50 | 50 µg (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human CDK12 / CRKRS Antibody (Internal, IHC) LS‑A7350
PathPlus™ Polyclonal Rabbit anti‑Human CDK12 / CRKRS Antibody (Internal, IHC) LS‑A7350
Antibody:
CDK12 / CRKRS Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Dog
Format:
Unconjugated, Unmodified
Overview
Antibody:
CDK12 / CRKRS Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Dog
Format:
Unconjugated, Unmodified
Specifications
Description
Cyclin-dependent kinase 12 (CDK12) phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. CDK12 regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. It preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. CDK12 is required for RNA splicing, possibly by phosphorylating SRSF1/SF2 and is involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human CDK12 / CRKRS
Synonyms
CDK12 | CDC2-related protein kinase 7 | CRK7 | Cyclin-dependent kinase 12 | HCDK12 | KIAA0904 | CRKR | CRKRS | Pksc
Host
Rabbit
Reactivity
Human, Monkey, Dog
(tested or 100% immunogen sequence identity)
Predicted
Rat, Bat, Bovine, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from internal region of human CDK12 / CRKRS. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Panda, Dog (100%); Elephant, Bovine, Rabbit (95%); Rat, Bat (90%); Mouse, Hamster, Horse (85%).
Epitope
Internal
Specificity
Human CDK12 / CRKRS. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except AKAP12 (55%).
Applications
- IHC
- IHC - Paraffin (6 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CDK12 / CRKRS
Validation
Breast, Carcinoma
Breast, Carcinoma
Prostate, cancer
Prostate, cancer
Brain, Substantia Nigra, nonpigmented neurons
Brain, Substantia Nigra, nonpigmented neurons
Anti-CDK12 / CRKRS antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ CDK12 / CRKRS Antibody (Internal) for IHC LS-A7350 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
Western blot, Immunoprecipitation
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/19/2024
Date Requested: 4/19/2024
