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CDK1 / CDC2

cyclin-dependent kinase 1

Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration.

Gene Name: cyclin-dependent kinase 1
Family/Subfamily: Protein Kinase , CDC2/CDK
Synonyms: CDK1, CDC28A, CDC2, CDKN1, Cyclin-dependent kinase 1, p34 protein kinase, p34CDC2, CDC2a, Cell cycle controller CDC2, Cell division protein kinase 1, PSTAIR
Target Sequences: NM_001786 NP_001777.1 P06493

Publications (5)

1
Distinct forms of human CDC2 identified by novel monoclonal antibodies. Luks J, Draetta G, Bartek J. European journal of biochemistry / FEBS. 1992 207:169-76. [PubMed:1628647] Related Antibodies: LS-C18772.
2
Proteolysis and tyrosine phosphorylation of p34cdc2/cyclin B. The role of MCM2 and initiation of DNA replication to allow tyrosine phosphorylation of p34cdc2. Ye XS, Fincher RR, Tang A, McNeal KK, Gygax SE, Wexler AN, Ryan KB, James SW, Osmani SA. The Journal of biological chemistry. 1997 272:33384-93. [PubMed:9407133] Related Antibodies: LS-C18772.
3
A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1. Palmer A, Gavin AC, Nebreda AR. The EMBO journal. 1998 17:5037-47. [PubMed:9724639] [PMC:PMC1170831] Related Antibodies: LS-C18772.
4
Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer. Jonsson M, Fjeldbo CS, Holm R, Stokke T, Kristensen GB, Lyng H. Neoplasia (New York, N.Y.). 2019 April;21:353-362. [Full Text Article] [PubMed:30856376] [PMC:PMC6411633]
5
Histone deacetylase HDAC4 promotes the proliferation and invasion of glioma cells. Jun-Yan Cai, Tong-Tong Xu, Ye Wang, Jing-Jian Chang, Jian Li, Xiao-Yang Chen, Xi Chen, Yi-Fei Yin, Xue-Jun Ni. International journal of oncology. 2018 Dec;53:2758-2768. [Full Text Article] [PubMed:30272277]
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Antibodies (249)
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CDK1 / CDC2 (249)
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No (248)
Yes (1)
CDK1 / CDC2 Antibody - IHC of p-CDC2 (Y15) pAb in paraffin-embedded human breast carcinoma tissue.
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CDK1 / CDC2 Rabbit anti-Human Polyclonal (pTyr15) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
50 µl/$327; 100 µl/$409
CDK1 / CDC2 Antibody - Anti-Cdc2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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CDK1 / CDC2 Mouse anti-Human Monoclonal (26E11) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
CDK1 / CDC2 Antibody - Mab anti-Human p34cdc2 antibody was used at a dilution of 1:1000 to detect human p34cdc2by Western blot of untreated (control) and drug treated (10 mM genistein) lysates of MCF-7 cells.
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CDK1 / CDC2 Mouse anti-Human Monoclonal (POH-1) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$485
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CDK1 / CDC2 Mouse anti-Xenopus Monoclonal (pSer/Thr) Antibody
Xenopus, Chicken, Mouse, Rat, Human
Func, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$647
CDK1 / CDC2 Antibody - Anti-Cdc2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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CDK1 / CDC2 Rabbit anti-Human Polyclonal (pThr14/Tyr15) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$674
CDK1 / CDC2 Antibody - Anti-Cdc2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CDK1 / CDC2 Mouse anti-Human Monoclonal (POH-1) Antibody
Bovine, Human, Non-Human Primates
ICC, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
CDK1 / CDC2 Antibody - Immunoperoxidase of monoclonal antibody to CDC2 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 0.3 ug/ml]
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CDK1 / CDC2 Mouse anti-Human Monoclonal (1A4-1A9) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$407
CDK1 / CDC2 Antibody - Immunohistochemical analysis of CDC2 (pT161) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CDK1 / CDC2 Rabbit anti-Human Polyclonal (pThr161) Antibody
Chicken, Zebrafish, Bovine, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$305
CDK1 / CDC2 Antibody - Immunohistochemical analysis of CDC2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CDK1 / CDC2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$289
CDK1 / CDC2 Antibody - CDK1 antibody Western blot of Fetal Muscle lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CDK1 / CDC2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Xenopus, Chicken, Zebrafish, Drosophila, Pig, Horse, Rat, Hamster, Sheep, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Human, Monkey
WB
Unconjugated
100 µl/$434
CDK1 / CDC2 Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CDK1 / CDC2 Mouse anti-Human Monoclonal (5F6) Antibody
Rabbit, Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
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CDK1 / CDC2 Mouse anti-Xenopus Monoclonal (C-Terminus) Antibody
Xenopus, Chicken, Rodent, Human
ELISA, Func, IHC, IHC-Fr, IP, WB
Unconjugated
200 µg/$660
CDK1 / CDC2 Antibody - Anti-Cdc2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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CDK1 / CDC2 Mouse anti-Human Monoclonal (POH-1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
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CDK1 / CDC2 Mouse anti-Xenopus Monoclonal (C-Terminus) (IMD-34) Antibody
Xenopus, Chicken, Mouse, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$331
CDK1 / CDC2 Antibody - IHC of p-CDC2 (T161) pAb in paraffin-embedded human breast carcinoma tissue.
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CDK1 / CDC2 Rabbit anti-Human Polyclonal (pThr161) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$327; 100 µl/$409
CDK1 / CDC2 Antibody - Western blot analysis of lysates from COS7 cells, using CDC2 (Phospho-Tyr15) Antibody. The lane on the right is blocked with the phospho peptide.
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CDK1 / CDC2 Rabbit anti-Human Polyclonal (pTyr15) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$306; 100 µl/$366
CDK1 / CDC2 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded human ovarian cancer tissues (left) and Lung Cancer Tissues (right) with DAB staining using Cdk1 Monoclonal Antibody.
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CDK1 / CDC2 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100 µl/$371
CDK1 / CDC2 Antibody - IHC of paraffin-embedded ovarian cancer tissues (left) and lung cancer tissues (right) using CDK1 mouse monoclonal antibody with DAB staining.
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CDK1 / CDC2 Mouse anti-Human Monoclonal (2G9) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$415
CDK1 / CDC2 Antibody - CDK1 Antibody in Immunohistochemistry (IHC)
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CDK1 / CDC2 Mouse anti-Human Monoclonal (2G9) Antibody
Mouse, Rat, Non-Human Primate, Human
ICC, IF, IHC, WB
Unconjugated
100 µl/$474
CDK1 / CDC2 Antibody - Cdk1 antibody POH-1 immunohistochemistry.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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CDK1 / CDC2 Mouse anti-Human Monoclonal (POH-1) Antibody
Bovine, Mink, Human, Monkey
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20 µg/$347; 100 µg/$522
CDK1 / CDC2 Antibody - Cdk1 antibody POH-1 immunohistochemistry.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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CDK1 / CDC2 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (POH-1) Antibody
Bovine, Mink, Human, Monkey
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free, BSA-free
100 µg/$522
CDK1 / CDC2 Antibody - CDK1 Antibody in Immunofluorescence (IF)
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CDK1 / CDC2 Mouse anti-Human Monoclonal (8C5A7F10) Antibody
Human
Flo, ICC, IF, WB
Unconjugated
100 µl/$474
CDK1 / CDC2 Antibody - Immunofluorescence (IF) analysis of HeLa cells using CDC2 Monoclonal Antibody (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
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CDK1 / CDC2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
100 µl/$371
CDK1 / CDC2 Antibody - Immunoperoxidase of monoclonal antibody to CDC2 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 1.5 ug/ml]
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CDK1 / CDC2 Mouse anti-Human Monoclonal (8F1) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$407
CDK1 / CDC2 Antibody - Hela cells stained with purified mouse monoclonal antibody against Cdc2(p34) (clone POH-1), followed by Rhodamine Red-X conjugated goat anti-mouse IgG and DAPI
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CDK1 / CDC2 Mouse anti-Human Monoclonal (POH-1) Antibody
Bovine, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$321
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).