Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
CDC25B, a CDC25 dual specificity protein phosphatase, has been shown to affect cell cycle regulation by activating cyclin-dependent kinases Cdk1 and Cdk2 during G2 phase. CDC25B also has been shown to possess oncogenic properties and has been implicated in lung, breast, esophagus, stomach, ovarian, and other cancers. Recently CDC25B has been shown to be a steroid receptor coactivator and this function is independent of the protein phosphatase activity in vitro. CDC25B deficient mice are viable but the female mice are sterile due to the arrest of cell division in oocytes. At least five mRNA splice variants have been documented for CDC25B.
|Gene Name:||cell division cycle 25B|
|Family/Subfamily:||Protein Phosphatase , CDC25|
|Synonyms:||CDC25B, CDC25B phosphatase, Cell division cycle 25B, M-phase inducer phosphatase 2, CDC25HU2|
|Target Sequences:||NM_021872 NP_068658.1 P30305|
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