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CD46

CD46 molecule, complement regulatory protein

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Gene Name: CD46 molecule, complement regulatory protein
Synonyms: CD46, AHUS2, CD46 antigen, MCP, Measles virus receptor, TLX, MIC10, TRA2.10, Membrane cofactor protein
Target Sequences: NM_002389 NP_002380.3 P15529

Publications (1)

1
Vaccination with adenovirus serotypes 35, 26, and 48 elicits higher levels of innate cytokine responses than adenovirus serotype 5 in rhesus monkeys. Teigler JE, Iampietro MJ, Barouch DH. Journal of virology. 2012 86:9590-8. [Full Text Article] [PubMed:22787208] Related Antibodies: LS-C96281.

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Antibodies (127)
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Primary (127)
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CD46 (155)
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CD46 Antibody - Anti-CD46 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD46 Mouse anti-Human Monoclonal (MEM-258) Antibody
Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
CD46 Antibody - Anti-CD46 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CD46 Mouse anti-Human Monoclonal (RPE) (MEM-258) Antibody
Human
Flo
RPE Conjugated
100 Tests/$485
CD46 Antibody - Anti-CD46 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CD46 Mouse anti-Human Monoclonal (3F1) Antibody
Human
ELISA, Flo, ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$485
CD46 Antibody - IHC of MCP / CD46 antibody. Frozen section of human placenta.
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CD46 Mouse anti-Human Monoclonal (13/42) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
200 µg/$595
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CD46 Rat anti-Mouse Monoclonal (MM10) Antibody
Mouse, Rat
Flo, IF, IHC, IHC-Fr, WB
Unconjugated
100 µg/$554
CD46 Antibody - Immunofluorescence analysis of HepG2 cells.
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CD46 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CD46 Antibody - Anti-MCP / CD46 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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CD46 Mouse anti-Human Monoclonal (Concentrated) (M177) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated, Concentrated
50 µg/$565
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CD46 Mouse anti-Human Monoclonal (Azide-free) (MEM-258) Antibody
Bovine, Human
Flo, IP, WB
Unconjugated, Azide-free
0.1 mg/$309
CD46 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) This image was taken for the unmodified form of this product. Other forms have not been tested.
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CD46 Mouse anti-Human Monoclonal (Azide-free) (169-1-EA.3) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated, Azide-free
50 µg/$460
CD46 Antibody - CD46 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human hepatocarcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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CD46 Rabbit anti-Human Polyclonal (aa317-343) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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CD46 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
FITC Conjugated
100 µg/$873
CD46 Antibody
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CD46 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
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CD46 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IP, WB
Unconjugated
100 µg/$331
CD46 Antibody - Surface staining of human peripheral blood cells with anti-CD46 (MEM-258) APC.
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CD46 Mouse anti-Human Monoclonal (APC) (MEM-258) Antibody
Bovine, Human
Flo, IP, WB
APC Conjugated
100 Tests/$365
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CD46 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, WB
FITC Conjugated
120 Tests/$626
CD46 Antibody - Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CD46 mouse mAb with DAB staining.
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CD46 Mouse anti-Human Monoclonal (1A5A5) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$459
CD46 Antibody - Immunofluorescence analysis of Hela cells using CD46 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
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CD46 Mouse anti-Human Monoclonal (5A8C11) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µg/$459
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CD46 Rabbit anti-Human Polyclonal (aa317-343) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
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CD46 Rabbit anti-Human Polyclonal (aa317-343) (Biotin) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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CD46 Rabbit anti-Human Polyclonal (aa317-343) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
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CD46 Rabbit anti-Human Polyclonal (aa317-343) (PE) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
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CD46 Rabbit anti-Human Polyclonal (aa317-343) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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CD46 Rabbit anti-Human Polyclonal (aa317-343) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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CD46 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo
FITC Conjugated
25 Tests/$263; 100 Tests/$323
CD46 Antibody - ICC/IF analysis of CD46 in HeLa cells. The cell was stained with CD46 antibody (1:100).The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).
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CD46 Mouse anti-Human Monoclonal (AT2G9) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
50 µl/$303; 100 µl/$365
Viewing 1-25 of 155 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).