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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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CD46

CD46 molecule, complement regulatory protein

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Gene Name: CD46 molecule, complement regulatory protein
Synonyms: CD46, AHUS2, CD46 antigen, MCP, Measles virus receptor, TLX, MIC10, TRA2.10, Membrane cofactor protein
Target Sequences: NM_002389 NP_002380.3 P15529

Publications (1)

1
Vaccination with adenovirus serotypes 35, 26, and 48 elicits higher levels of innate cytokine responses than adenovirus serotype 5 in rhesus monkeys. Teigler JE, Iampietro MJ, Barouch DH. Journal of virology. 2012 86:9590-8. (IHC-P) [Full Text Article] [PubMed:22787208] Related Antibodies: LS-C96281.

Viewing 1-25 of 142 items
CD46 Antibody - Anti-CD46 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone MEM-258] (IgG1) to Human CD46
Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
50µg   1mg/ml   $425.00
CD46 Antibody - Anti-CD46 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone MEM-258] (IgG1) to Human CD46
Human
Flo
RPE Conjugated
100tst   $405.00
CD46 Antibody - Anti-CD46 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone 3F1] (IgG1,k) to Human CD46
Human
ELISA, Flo, ICC, IHC, IHC-P, WB
Unconjugated
100µg   $425.00
CD46 Antibody - Anti-MCP / CD46 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Mouse Monoclonal [clone M177] (IgG1) to Human CD46
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated, Concentrated
50µg   0.1mg/ml   $585.00
CD46 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone 169-1-EA.3] (IgG2a) to Human CD46
Human
Flo, IHC, IHC-P, WB
Unconjugated, Azide-free
50µg   1mg/ml   $425.00
CD46 Antibody - IHC of MCP / CD46 antibody. Frozen section of human placenta.
Select
(1) Publication(s)
Mouse Monoclonal [clone 13/42] (IgG1) to Human CD46
Human
IHC, IHC-Fr, IHC-P
Unconjugated
200µg   $415.00
Select
Rat Monoclonal [clone MM10] (IgG2a) to Mouse CD46
Mouse, Rat
Flo, IF, IHC, IHC-Fr, WB
Unconjugated
100µg   $475.00
Select
Rabbit Polyclonal (IgG) to Human CD46
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human CD46
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CD46
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CD46
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CD46
Human
ELISA, Flo, ICC, IF, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CD46
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human CD46
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Mouse Monoclonal [clone MEM-258] (IgG1) to Human CD46
Bovine, Human
Flo, IP, WB
Unconjugated, Azide-free
0.1mg   1mg/ml   $260.00
Select
Mouse Monoclonal (IgG1) to Human CD46
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
FITC Conjugated
100µg   $965.00
CD46 Antibody - Immunofluorescence analysis of HepG2 cells.
Select
Rabbit Polyclonal (IgG) to Human CD46
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl   $235.00; 100µl   $295.00; 200µl   $385.00
CD46 Antibody - Surface staining of human peripheral blood cells with anti-CD46 (MEM-258) APC.
Select
Mouse Monoclonal [clone MEM-258] (IgG1) to Human CD46
Bovine, Human
Flo, IP, WB
APC Conjugated
100tst   $315.00
Select
Mouse Monoclonal (IgG2a,k) to Human CD46
Human
Flo, WB
FITC Conjugated
120tst   $495.00
CD46 Antibody - CD46 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human hepatocarcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
Rabbit Polyclonal to Human CD46
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
CD46 Antibody - ICC/IF analysis of CD46 in HeLa cells. The cell was stained with CD46 antibody (1:100).The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).
Select
Mouse Monoclonal [clone AT2G9] (IgG2a,k) to Human CD46
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
50µl   1mg/ml   $275.00; 100µl   1mg/ml   $345.00
Select
Rabbit Polyclonal to Human CD46
Human
ELISA, ICC, IF, IHC, IHC-P
Unconjugated
50µl   $245.00; 100µl   $305.00
Select
Mouse Monoclonal (IgG1) to Human CD46
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100µg   $800.00
CD46 Antibody - CD46, Human, mAb M177, functional study antibody, low endotoxin
Select
Mouse Monoclonal (IgG1) to Human CD46
Human
Flo, Func, IHC, IHC-Fr, IP, RIA, WB
Unconjugated, Low Endotoxin
0.5mg   $1,605.00
Select
Mouse Monoclonal to Human CD46
Human
Flo, ICC, IF
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00

Viewing 1-25 of 142 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).