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CD4

CD4 molecule

CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Gene Name: CD4 molecule
Synonyms: CD4, CD4 antigen, CD4 receptor, CD4mut, CD4 antigen (p55), CD4 molecule
Target Sequences: NM_000616 NP_000607.1 P01730

Publications (10)

1
Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, Mannose Receptor, and DC-SIGN. Zenaro E, Donini M, Dusi S. Journal of leukocyte biology. 2009 86:1393-401. [PubMed:19773555]
2
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH. Journal of translational medicine. 2009 7:89. [PubMed:19849846] [PMC:PMC2770477] Related Antibodies: LS-C41126.
3
Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates. Cicin-Sain L, Smyk-Pearson S, Smyk-Paerson S, Currier N, Byrd L, Koudelka C, Robinson T, Swarbrick G, Tackitt S, Legasse A, Fischer M, Nikolich-Zugich D, Park B, Hobbs T, Doane CJ, Mori M, Axthelm MK, Axthelm MT, Lewinsohn DA, Nikolich-Zugich J. Journal of immunology (Baltimore, Md. : 1950). 2010 184:6739-45. [PubMed:20483749] [PMC:PMC3504654] Related Antibodies: LS-C41126.
4
Survival of skin graft between transgenic cloned dogs and non-transgenic cloned dogs. Kim GA, Oh HJ, Kim MJ, Jo YK, Choi J, Park JE, Park EJ, Lim SH, Yoon BI, Kang SK, Jang G, Lee BC. PloS one. 2014 9:e108330. (IP; Dog) [Full Text Article] [PubMed:25372489] [PMC:PMC4220905] Related Antibodies: LS-C122857.
5
Acute BVDV-2 infection in beef calves delays humoral responses to a non-infectious antigen challenge. UCVM Class of, McCorkell R, Horsman SR, Wynne-Edwards K, Muench G, van Drunen Littel-van den Hurk S, Waeckerlin R, Eschbaumer M, Dardari R, Chaiyakul M, Gajda P, Czub M, van der Meer F. The Canadian veterinary journal = La revue veterinaire canadienne. 2015 56:1075-83. (IP; Bovine) [PubMed:26483584] [PMC:PMC4572827]
6
Conformational Engineering of HIV-1 Env Based on Mutational Tolerance in the CD4 and PG16 Bound States. Jeremiah D Heredia, Jihye Park, Hannah Choi, Kevin S Gill, Erik Procko. Journal of virology. 2019 June;93: [Full Text Article] [PubMed:30894475] [PMC:PMC6532070] Related Antibodies: LS-C134227.
7
Crucial role of OX40/OX40L signaling in a murine model of asthma. Wei Lei, Daxiong Zeng, Gaoqin Liu, Yehan Zhu, Jiajia Wang, Hongya Wu, Junhong Jiang, Jianan Huang. Molecular medicine reports. 2018 Mar;17:4213-4220. [Full Text Article] [PubMed:29344664] [PMC:PMC5802192] Related Antibodies: LS-C62734.
8
Correlation between innate and adaptive immunity response in TB children post BCG vaccination. Is it effective or not?: Cross-sectional study. Rahmini Shabariah, Farsida, Mochammad Hatta, Ilhamjaya Patellongi, Irfan Idris, Arif Santoso, Andi Asadul Islam, Rosdiana Natzir, Bob Wahyudin, Warsinggih, Sanjoyo. Annals of medicine and surgery (2012). 2022 May;77:103586. [Full Text Article] [PubMed:35638072] [PMC:PMC9142374]
9
Comparison TLR2 and TLR4 serum levels in children with pulmonary and extrapulmonary tuberculosis with and without a Bacillus Calmette-Guérin (BCG) scar. Rahmini Shabariah, Mochammad Hatta, Irfan Idris, Arif Santoso, Ilhamjaya Patellongi, Tria Astika Endah Permatasari, Farsida, Andi Asadul Islam, Rosdiana Natzir, Bob Wahyudin, Warsinggih, Emilda. Journal of clinical tuberculosis and other mycobacterial diseases. 2021 December;25:100272. [Full Text Article] [PubMed:34504953] [PMC:PMC8416952]
10
EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4+CD25+FOXP3+ REGULATORY T CELLS. Weaver KF, Stokes JV, Gunnoe SA, Follows JS, Shafer L, Ammari MG, Archer TM, Thomason JM, Mackin AJ, Pinchuk LM. Journal of veterinary medicine and research. 2014 1: (Flo; Canine) [PubMed:25950023] [PMC:PMC4418640] Related Antibodies: LS-C127352.
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Products
Proteins (19)
Over-Expression Lysate (4)
Recombinant (15)
CD4 (19)
No (19)
6His, N-terminus (1)
Fc, C-terminus (1)
GST (2)
His (4)
His,C-terminus (2)
His-GST (1)
His-S (2)
Myc-DDK (Flag) (5)
Human (13)
Mouse (2)
Rabbit (1)
Rhesus monkey (1)
293T Cells (2)
CHO Cells (1)
E. coli (6)
HEK 293 Cells (4)
Human Cells (2)
Mammalian Cells (2)
Wheat Germ Extract (2)
Purified (7)
Low endotoxin level (5)
Biologically active (1)
Select
CHO Cells
None
Biologically active
41.3 kDa or 45-55 kDa
10 µg/$268; 50 µg/$349
CD4 Protein
Select
E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
CD4 Protein - Recombinant Cluster Of Differentiation 4 By SDS-PAGE
Select
E. coli
His
41.9 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
CD4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His, N-terminus
45.3kDa
100 µg/$1,128; 20 µg/$721
CD4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
31.7 kDa
100 µg/$494
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
67.6 kDa
10 µg/$277; 50 µg/$389
CD4 Protein - Recombinant Cluster Of Differentiation 4 By SDS-PAGE
Select
E. coli
His-GST
100.6 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
CD4 Protein - 12.5% SDS-PAGE of human CD4 stained with Coomassie Blue
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Wheat Germ Extract
GST
76.12 kDa
2 µg/$439
CD4 Protein - 12.5% SDS-PAGE of human CD4 stained with Coomassie Blue
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Wheat Germ Extract
GST
77.5 kDa
2 µg/$439
CD4 Protein - Purified recombinant protein CD4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
48.3 kDa
20 µg/$1,107
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
42.2 kDa
100 µg/$721
CD4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
51.11 kDa
20 µg/$150
CD4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
31.7 kDa
20 µg/$150
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
21.7 kDa
100 µg/$721
CD4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
51.11 kDa
100 µg/$494
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.8 kDa
100 µg/$721
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.7 kDa
10 µg/$266; 50 µg/$335
CD4 Protein - Recombinant Cluster Of Differentiation 4 By SDS-PAGE
Select
E. coli
His-S
47.0 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
CD4 Protein - Recombinant Cluster Of Differentiation 4 By SDS-PAGE
Select
E. coli
His-S
46.5 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Viewing 1-19 of 19 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).