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CALR3 belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy.
Gene Name: | calreticulin 3 |
Synonyms: | CALR3, Calreticulin 3, Calreticulin-2, Calreticulin-3, Calsperin, CRT2, CT93, CMH19, Cancer/testis antigen 93 |
Target Sequences: | Q96L12 Q96L12 |
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