c-Kit / CD117

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

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Products

Proteins (20)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (4)

Recombinant (15)

Target

c-Kit / CD117 (20)

Publications

No (20)

Tag

6His, N-terminus (1)

Fc (1)

Fc, C-terminus (2)

GST (1)

GST, N-terminus (1)

His (5)

His, C-Terminal (1)

His, N-terminus (1)

His,C-terminus (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (4)

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Species

Human (13)

Mouse (3)

Rat (2)

Source

293T Cells (2)

Baculovirus (1)

E. coli (4)

HEK 293 Cells (5)

Human (1)

Human Cells (4)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (9)

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Human c-Kit / CD117 Protein (Recombinant His, C-Terminal) (Gln26-Thr520) - LS-G55681

Source:

Human

Tag:

His, C-Terminal

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.5kD

Price:

10 µg/$266; 50 µg/$376; 500 µg/$1,067; 1 mg/$1,369

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Human c-Kit / CD117 Protein (Recombinant His-T7) (aa321-520) - LS-G11648

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.4 kDa

Price:

10 µg/$277; 50 µg/$415; 100 µg/$662; 200 µg/$830; 1 mg/$1,916; 500 µg/$1,465; 5 mg/$2,899; 2 mg/$2,101

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c-Kit / CD117 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123326

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.7 kDa

Price:

100 µg/$494

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Human c-Kit / CD117 Protein (Recombinant GST, N-terminus) (aa41-140) - LS-G59070

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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c-Kit / CD117 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119313

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.3 kDa

Price:

100 µg/$710

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Human c-Kit / CD117 Protein (Recombinant His, N-terminus) - LS-G145967

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

20.1 kDa

Price:

20 µg/$270; 100 µg/$390

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Human c-Kit / CD117 Protein (Recombinant GST) (Full Length) - LS-G29131

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

136.3 kDa

Price:

2 µg/$439

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Human c-Kit / CD117 Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Pro27-Leu977) - LS-G26874

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

110 kDa

Price:

200 µl/$283

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Human c-Kit / CD117 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77240

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.7 kDa

Price:

20 µg/$150

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Human c-Kit / CD117 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77241

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

109.3 kDa

Price:

20 µg/$215

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Mouse c-Kit / CD117 Protein (Recombinant Fc) (Met1-Thr523) - LS-G98802

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

82.5 kDa

Price:

100 µg/$721

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Mouse c-Kit / CD117 Protein (Recombinant His) (Met1-Thr523) - LS-G98803

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

57 kDa

Price:

100 µg/$721

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Human c-Kit / CD117 Protein (Recombinant His) (Val50-Gln190) - LS-G97635

Source:

E. coli

Tag:

His

Molecular Weight:

17.9 kDa

Price:

100 µg/$843

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Human c-Kit / CD117 Protein (Recombinant His) (Met1-Thr516) - LS-G97636

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.7 kDa

Price:

100 µg/$843

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Human c-Kit / CD117 Protein (Recombinant His-GST) (Thr540-Val972) - LS-G97637

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

76.8 kDa

Price:

50 µg/$502

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Human c-Kit / CD117 Protein (Recombinant Fc, C-terminus) (Met1-Thr516) - LS-G139924

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

82 kDa

Price:

50 µg/$502

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Rat c-Kit / CD117 Protein (Recombinant Fc, C-terminus) (Met1-Thr522) - LS-G138341

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

82.4 kDa

Price:

100 µg/$843

Select

Human c-Kit / CD117 Protein (Recombinant His,C-terminus) (Gln26-Thr520) - LS-G139014

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.5 kDa

Price:

10 µg/$266; 50 µg/$371

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Mouse c-Kit / CD117 Protein (Recombinant His) (aa343-527) - LS-G11641

Source:

E. coli

Tag:

His

Molecular Weight:

22.2 kDa

Price:

10 µg/$287; 50 µg/$477; 100 µg/$762; 200 µg/$952; 1 mg/$2,083; 500 µg/$1,613; 5 mg/$3,333; 2 mg/$2,272

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Rat c-Kit / CD117 Protein (Recombinant His) (Met1-Thr522) - LS-G98434

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.9 kDa

Price:

50 µg/$502

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