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Catalog Number Size Price
LS-A9389-50 50 µg (1 mg/ml) $460 
c-Kit / CD117 Antibody - Anti-c-Kit antibody IHC of human spleen, central artery and lymphocytes within periarteriolar lymphoid sheaths. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
c-Kit / CD117 Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
c-Kit / CD117 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
c-Kit / CD117 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
c-Kit / CD117 Antibody - Anti-c-Kit antibody IHC of human spleen, central artery and lymphocytes within periarteriolar lymphoid sheaths. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
c-Kit / CD117 Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
c-Kit / CD117 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
c-Kit / CD117 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PathPlus™ Polyclonal Rabbit anti‑Human c‑Kit / CD117 Antibody (Extracellular Domain, IHC) LS‑A9389

PathPlus™ Polyclonal Rabbit anti‑Human c‑Kit / CD117 Antibody (Extracellular Domain, IHC) LS‑A9389

Note: This antibody replaces LS-C78846
Antibody:
c-Kit / CD117 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A9389-50

Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
c-Kit / CD117 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CD117 (mast/stem cell growth factor receptor, SCFR, KIT oncogene) is a protein tyrosine kinase receptor for the cytokine KITLG/SCF. Activation regulates apoptosis and cell proliferation, differentiation, chemotaxis, and adhesion. Altered forms are associated with cancer. CD117 is expressed on hematopoietic stem cells and progenitor cells and some nonhematopoietic cells such as mast cells, melanocytes, germ cells, interstitial cells of Cajal, skin adnexa epithelial cells, and some cerebellar neurons and in breast tissue. It is also expressed in tumors of these cell types. Staining is used primarily to identify gastrointestinal stromal tumors and also small-cell lung carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, breast carcinoma, glioblastoma, and melanoma. References: Int J Biochem Cell Biol. 2007;39(11):1995-1998. doi: 10.1016/j.biocel.2006.12.005; Appl Immunohistochem Mol Morphol. 2005;13(3):205-220. PMID: 16082245; Oncogene. 2005;24(26):4271-4280. doi: 10.1038/sj.onc.1208587; Hum Pathol. 2002;33(12):1182-1187. doi: 10.1053/hupa.2002.129199
Target
Human c-Kit / CD117
Synonyms
KIT | C-Kit | CD117 | PBT | Piebald trait | Piebald trait protein | Proto-oncogene c-Kit | SCFR | Soluble KIT variant 1 | Tyrosine-protein kinase Kit | p145 c-kit | CD117 antigen
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from extracellular domain of human c-Kit. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey (94%); Marmoset, Mouse, Rat (88%); Hamster, Pig (81%).
Epitope
Extracellular Domain
Specificity
Human c-Kit. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (20 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistochemistry: The unconjugated form was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for the unconjugated form was determined to be 20 ug/ml.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About c-Kit / CD117
P10721 NM_000222 NP_000213.1

Validation

c-Kit / CD117 Antibody - Anti-c-Kit antibody IHC of human spleen, central artery and lymphocytes within periarteriolar lymphoid sheaths. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-c-Kit antibody IHC of human spleen, central artery and lymphocytes within periarteriolar lymphoid sheaths. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-c-Kit antibody IHC of human spleen, central artery and lymphocytes within periarteriolar lymphoid sheaths. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

c-Kit / CD117 Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)

c-Kit / CD117 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

c-Kit / CD117 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ c-Kit / CD117 Antibody (Extracellular Domain) for IHC LS-A9389 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

Tissue-infiltrating immune cells contribute to understanding the pathogenesis of Kimura disease: A case report. Maehara T, Munemura R, Shimizu M, Kakizoe N, Kaneko N, Murakami Y, Masafumi M, Kiyoshima T, Kawano S, Nakamura S. Medicine. 2019 December;98:e18300.

Customer Reviews (0)


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Technical.Support@LSBio.com

Requested From: United States
Date Requested: 8/18/2022