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BTF / BCLAF1 is a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | BCL2-associated transcription factor 1 |
Family/Subfamily: | Apoptosis |
Synonyms: | BCLAF1, BK211L9.1, BTF, KIAA0164 |
Target Sequences: | NM_014739 NP_055554.1 Q9NYF8 |
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