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BBC3 / PUMA

BCL2 binding component 3

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Gene Name: BCL2 binding component 3
Family/Subfamily: Apoptosis , not assigned-Apoptosis
Synonyms: BBC3, Bcl-2-binding component 3, BCL2 binding component 3, JFY-1, JFY1, PUMA, PUMA alpha
Target Sequences: NM_014417 NP_055232.1 Q9BXH1

Publications (2)

1
Aberrant activation of notch signaling in human breast cancer. Stylianou S, Clarke RB, Brennan K. Cancer research. 2006 66:1517-25. [PubMed:16452208]
2
Bcl-2 Is a Therapeutic Target for Hypodiploid B-Lineage Acute Lymphoblastic Leukemia. Ernesto Diaz-Flores, Evan Q Comeaux, Kailyn L Kim, Ella Melnik, Kyle Beckman, Kara L Davis, Kevin Wu, Jon Akutagawa, Olga Bridges, Roberta Marino, Margo Wohlfeil, Benjamin S Braun, Charles G Mullighan, Mignon L Loh. Cancer research. 2019 May;79:2339-2351. [Full Text Article] [PubMed:30862722] [PMC:PMC6497548] Related Antibodies: LS-C98860.

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Proteins (9)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (4)
Recombinant (4)
BBC3 / PUMA (9)
No (9)
6His, N-terminus (1)
His, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (6)
Human (6)
Rat (1)
293T Cells (2)
E. coli (2)
HEK 293 Cells (5)
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HEK 293 Cells
6His, N-terminus
30-40 kDa
200 µl/$283
BBC3 / PUMA Protein - Purified recombinant protein BBC3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
20.4 kDa
20 µg/$1,107
BBC3 / PUMA Protein - Recombinant  p53 Upregulated Modulator Of Apoptosis By SDS-PAGE
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E. coli
His-T7
14.5 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
BBC3 / PUMA Protein - Purified recombinant protein BBC3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
26.3 kDa
20 µg/$1,107
BBC3 / PUMA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.4 kDa
20 µg/$150
BBC3 / PUMA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
26.3 kDa
20 µg/$150
BBC3 / PUMA Protein - Recombinant Human PUMA/BBC3 protein (His Tag)
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E. coli
His, N-terminus
20.1kDa
20 µg/$270; 100 µg/$390
BBC3 / PUMA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.4 kDa
100 µg/$494
BBC3 / PUMA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
26.3 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).