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Infectious Disease
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B2M / Beta 2 Microglobulin
beta-2-microglobulin
B2M / Beta 2 Microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
| Gene Name: | beta-2-microglobulin |
| Synonyms: | B2M, Beta 2 Microglobulin, Beta-2-microglobulin, Beta-2-microglobin |
| Target Sequences: | NM_004048 NP_004039.1 P61769 |
Publications (9)
1
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Meissner TB, Li A, Biswas A, Lee KH, Liu YJ, Bayir E, Iliopoulos D, van den Elsen PJ, Kobayashi KS. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:13794-9.
[PubMed:20639463]
[PMC:PMC2922274]
Related Antibodies: LS-B2200.
2
Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules. Rizvi SM, Del Cid N, Lybarger L, Raghavan M. Journal of immunology (Baltimore, Md. : 1950). 2011 186:2309-20.
[PubMed:21263072]
[PMC:PMC3057457]
Related Antibodies: LS-B2200.
3
NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression. Meissner TB, Liu YJ, Lee KH, Li A, Biswas A, van Eggermond MC, van den Elsen PJ, Kobayashi KS. Journal of immunology (Baltimore, Md. : 1950). 2012 188:4951-8.
[PubMed:22490869]
[PMC:PMC3345046]
Related Antibodies: LS-B2200.
☰ Filters
Products
Proteins
(31)
Type
Native
(1)
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(26)
Target
B2M / Beta 2 Microglobulin
(31)
Application
SDS-PAGE
(2)
Publications
No
(31)
Tag
10His, N-terminus + Myc, C-terminus
(1)
6His, C-terminus
(1)
6His, N-terminus
(6)
DDK,C-terminus
(1)
Fc, C-terminus
(1)
GST
(1)
His
(6)
His, N-Terminal
(1)
His, N-terminus
(2)
His,C-terminus
(5)
His-GST
(1)
Myc-DDK (Flag)
(3)
Species
Crab-eating macaque
(2)
Dog
(1)
Human
(18)
Mouse
(4)
Rat
(3)
Sheep
(1)
Source
293T Cells
(1)
E. coli
(11)
HEK 293 Cells
(9)
Human
(2)
Human Cells
(3)
Mammalian Cells
(3)
Sf9 Cells
(1)
Wheat Germ Extract
(1)
Purification
Purified
(7)
Low Endotoxin Level
Low endotoxin level
(11)
E. coli
His, N-Terminal
12.8 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
HEK 293 Cells
6His, N-terminus
14 kDa
10 µg/$289; 50 µg/$360; 100 µg/$432; 250 µg/$726; 500 µg/$1,270
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
13.5 kDa
100 µg/$532; 1 mg/$2,785
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.77kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant mouse B2M comprises 110 amino acids and has a calculated molecular mass of 13 kDa. The apparent molecular mass of rmB2M is approximately 15 kDa in SDS-PAGE under reducing conditions.
50 µg/$441; 1 mg/$2,324
Human
None
1 mg/$777; 10 mg/$3,335
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human B2M consists of 110 amino acids and migrates as an approximately 13.5 kDa band in SDS-PAGE under reducing conditions as predicted.
100 µg/$403; 1 mg/$1,697
E. coli
His, N-terminus
11.64kDa
20 µg/$270; 100 µg/$390
Sf9 Cells
DDK,C-terminus
12 kDa
20 µg/$677
E. coli
His, N-terminus
11.6kDa
20 µg/$270; 100 µg/$390
HEK 293 Cells
His
13.2 kDa
10 µg/$335; 50 µg/$622; 100 µg/$932
Wheat Germ Extract
GST
38.83 kDa
10 µg/$479; 25 µg/$670
HEK 293 Cells
6His, N-terminus
13.5 kDa
100 µg/$298
HEK 293 Cells
6His, N-terminus
13.5 kDa
200 µl/$283
Human
None
13.2kDa
50 µg/$622; 10 µg/$310; 200 µg/$1,185; 100 µg/$992; 1 mg/$2,410; 500 µg/$1,915; 5 mg/$4,341; 2 mg/$2,603
HEK 293 Cells
Myc-DDK (Flag)
11.7 kDa
20 µg/$1,107
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
13 kDa
50 µg/$721
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
13 kDa
50 µg/$721
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.0 kDa
10 µg/$233; 50 µg/$269
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14kD
10 µg/$233; 50 µg/$269; 500 µg/$508; 1 mg/$664
E. coli
6His, N-terminus
13.5 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.5 kDa
10 µg/$277; 50 µg/$389
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.8 kDa
10 µg/$277; 50 µg/$389
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.77 kDa
10 µg/$288; 50 µg/$436
E. coli
His
10 µg/$279; 50 µg/$373; 20 µg/$329; 100 µg/$479; 250 µg/$769; 500 µg/$1,243
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product results
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