LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us

AXL

AXL receptor tyrosine kinase

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.

Gene Name: AXL receptor tyrosine kinase
Family/Subfamily: Protein Kinase , Axl
Synonyms: AXL, AXL transforming sequence/gene, Oncogene AXL, AXL oncogene, AXL receptor tyrosine kinase, JTK11, Tyro7, UFO
Target Sequences: NM_001699 NP_001690.2 P30530

Filtered By: None
Type
Over-Expression Lysate (3)
Recombinant (8)
Target
AXL (11)
Tag
GST (1)
GST,N-terminus (2)
His (1)
His + Fc (1)
His + S (1)
Myc + DDK (4)
Species
Human (7)
Mouse (1)
Rat (1)
Source
293T Cells (1)
E. coli (1)
HEK 293 Cells (3)
Human Cells (2)
Insect Cells (1)
Wheat Germ Extract (3)
Purification
Purified (3)
Known Endotoxin Level
Known endotoxin level (2)
Has biological activity
Has biological activity (1)
Showing 1-11 of 11 results

Human AXL Protein (Recombinant GST,N-terminus) (aa30-140) - LS-G57868
Wheat Germ Extract
111 AA
GST,N-terminus
None
No known endotoxin level
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.
12.5% SDS-PAGE Stained with Coomassie Blue.

Human AXL Protein (Recombinant GST,N-terminus) (aa787-885) - LS-G57870
Wheat Germ Extract
99 AA
GST,N-terminus
None
No known endotoxin level
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.
12.5% SDS-PAGE Stained with Coomassie Blue.

Human AXL Protein (Recombinant GST) (Full Length) - LS-G27591
Wheat Germ Extract
894 AA
GST
None
No known endotoxin level
124.8 kDa
2µg 0.08mg/ml  $385.00
12.5% SDS-PAGE of human AXL stained with Coomassie Blue
12.5% SDS-PAGE of human AXL stained with Coomassie Blue

Rat AXL Protein (Recombinant His + S) (aa21-202) - LS-G26097
E. coli
His + S
None
No known endotoxin level
23.5 kDa
10µg  $285.00; 50µg  $485.00; 100µg  $560.00; 200µg  $965.00
Recombinant  AXL Receptor Tyrosine Kinase By SDS-PAGE
Recombinant  AXL Receptor Tyrosine Kinase By SDS-PAGE

Human AXL Protein (Recombinant His) (Met1-Pro449) - LS-G98515
Human Cells
His
None
Less than 1.0 EU/µg protein (determined by LAL method).
46.5 kDa
100µg  $485.00; 200µg  $815.00

Human AXL Protein (Recombinant) - LS-G131622
Insect Cells
None
Has biological activity
No known endotoxin level
~55 kDa
10µg  $365.00

Human AXL Protein (Recombinant Myc + DDK) (Full Length) - LS-G67242
HEK 293 Cells
946 AA
Myc + DDK
None
No known endotoxin level
98.2 kDa
20µg  $815.00
Purified recombinant protein AXL was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Purified recombinant protein AXL was analyzed by SDS-PAGE gel and Coomassie Blue Staining

Mouse AXL Protein (Recombinant His + Fc) (Met1-Pro443) - LS-G98056
Human Cells
His + Fc
None
Less than 1.0 EU/µg protein (determined by LAL method).
74.5 kDa
50µg  $545.00; 100µg  $815.00

Human AXL Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G79403
293T Cells
946 AA
Myc + DDK
None
No known endotoxin level
98.2 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

AXL Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G110569
HEK 293 Cells
946 AA
Myc + DDK
None
No known endotoxin level
98.2 kDa
100µg  $345.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

AXL Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G118452
HEK 293 Cells
937 AA
Myc + DDK
None
No known endotoxin level
97.4 kDa
100µg  $475.00
Showing 1-11 of 11 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


Get Social With Us!
Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy