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AIFM1 / AIF / PDCD8

Apoptosis-inducing Factor, Mitochondrion-associated, 1

Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli. AIF is highly conserved between human and mouse and widely expressed.

Gene Name: Apoptosis-inducing Factor, Mitochondrion-associated, 1
Family/Subfamily: Apoptosis , not assigned-Apoptosis
Synonyms: AIFM1, AIF, COXPD6, PDCD8, Programmed cell death 8
Target Sequences: NM_004208 NP_004199.1 O95831

Publications (2)

1
Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury. Cao G, Xing J, Xiao X, Liou AK, Gao Y, Yin XM, Clark RS, Graham SH, Chen J. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 27:9278-93. (WB) [PubMed:17728442]
2
AIF inhibits tumor metastasis by protecting PTEN from oxidation. Shen SM, Guo M, Xiong Z, Yu Y, Zhao XY, Zhang FF, Chen GQ. EMBO reports. 2015 16:1563-80. (WB; Human) [Full Text Article] [PubMed:26415504] [PMC:PMC4641507] Related Antibodies: LS-C147989.

☰ Filters
Antibodies (102)
ELISA Kits (22)
Proteins (15)
Custom (4)
Over-Expression Cell Culture Supernatant (1)
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AIFM1 / AIF / PDCD8 (139)
Human (110)
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AIFM1 / AIF / PDCD8 Antibody - Anti-AIFM1 / AIF antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
AIFM1 / AIF / PDCD8 Antibody - Anti-AIFM1 / AIF antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
AIFM1 / AIF / PDCD8 Antibody - IHC of AIF in formalin-fixed, paraffin-embedded normal human colon using AIFM1 / AIF / PDCD8 Antibody at 1:2000. Hematoxylin-Eosin counterstain. In this example, AIF expression is predominant in the upper part of the crypt.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa151-169) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
AIFM1 / AIF / PDCD8 Antibody - Anti-AIFM1 / AIF antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
AIFM1 / AIF / PDCD8 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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AIFM1 / AIF / PDCD8 Goat anti-Human Polyclonal Antibody
Human
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
AIFM1 / AIF / PDCD8 Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with AIFM1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa70-98) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
AIFM1 / AIF / PDCD8 Antibody - Immunohistochemical analysis of AIFM1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Sheep, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$299
AIFM1 / AIF / PDCD8 Antibody - IHC of paraffin-embedded human breast cancer tissues using AIF mouse monoclonal antibody with DAB staining.
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AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal (4E7) Antibody
Mouse, Rat, Human, Monkey
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$447
AIFM1 / AIF / PDCD8 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded Human Breast cancer tissues with DAB staining using AIF-M1 Monoclonal Antibody.
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AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal Antibody
Rat, Human, Monkey
ELISA, Flo, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
AIFM1 / AIF / PDCD8 Antibody - AIF antibody IHC-paraffin: Mouse Cardiac Muscle Tissue.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa582-613) Antibody
Rabbit, Mouse, Bovine, Rat, Hamster, Pig, Horse, Bat, Gibbon, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$470
AIFM1 / AIF / PDCD8 Antibody
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$567
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AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
Flo, ICC, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$361; 100 µl/$421; 200 µl/$481
AIFM1 / AIF / PDCD8 Antibody - Immunohistochemistry of paraffin-embedded human esophageal tissue.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, IP, WB
Unconjugated
20 µl/$287; 50 µl/$329; 100 µl/$407; 200 µl/$509
AIFM1 / AIF / PDCD8 Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
AIFM1 / AIF / PDCD8 Antibody - AIF Antibody in Immunofluorescence (IF)
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AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal (4E7E11) Antibody
Mouse, Rat, Primate, Human
ICC, IF, WB
Unconjugated
100 µg/$528
AIFM1 / AIF / PDCD8 Antibody - Western blot of AIF-M1 antibody
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
AIFM1 / AIF / PDCD8 Antibody - ICC/IF analysis of AIFM1 in Hep3B cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human AIFM1 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
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AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal (AT22E9) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
AIFM1 / AIF / PDCD8 Antibody - AIFM1 / AIF antibody. IHC(P): Human Lung Cancer Tissue.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa596-613) Antibody
Rabbit, Mouse, Sheep, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$470
AIFM1 / AIF / PDCD8 Antibody - Anti-AIFM1 / AIF antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa211-260) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
AIFM1 / AIF / PDCD8 Antibody - Anti-AIFM1 / AIF antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (aa211-260) (FITC) Antibody
Zebrafish, Pig, Horse, Mouse, Dog, Bovine, Rat, Hamster, Human, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$695
AIFM1 / AIF / PDCD8 Antibody - Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-AIFM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal (aa134-483) (OTI4E6) Antibody
Mouse, Human
IHC, WB
Unconjugated
100 µl/$434
AIFM1 / AIF / PDCD8 Antibody - Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-AIFM1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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AIFM1 / AIF / PDCD8 Mouse anti-Human Monoclonal (aa134-483) (Carrier-free) (OTI4E6) Antibody
Mouse, Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
AIFM1 / AIF / PDCD8 Antibody - Western blot of AIF-M1 (Y85) pAb in extracts from HUVEC cells.
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AIFM1 / AIF / PDCD8 Rabbit anti-Human Polyclonal (Tyr85) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
Viewing 1-25 of 139 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).