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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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AGAP2 / PIKE

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts with nuclear phosphoinositide 3-kinase (PI3 kinase) to stimulate its lipid kinase activity. PIKE exists in multiple isoforms; a shorter C-terminal isoform (PIKE-A) has also been identified as centaurin gamma 1. The longest isoform (PIKE-L) has been shown to bind to the adaptor protein Homer and thereby link to metabotropic glutamate receptors, leading to activation of PI3 kinase activity and prevention of neuronal apoptosis. Overexpression of PIKE-A enhances Akt activity and promotes cancer cell invasion, whereas decreased expression of PIKE-A via dominant negative expression of PIKE-A or PIKE-A knockdown inhibits these processes. In many human cancers, expression of PIKE-A is enhanced, leading to increased Akt activity and preventing apoptosis. Also known as: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.

Gene Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: AGAP2, AGAP-2, Centaurin, gamma 1, Cnt-g1, Centaurin-gamma-1, KIAA0167, GGAP2, PIKE, CENTG1
Target Sequences: NM_014770 NP_055585.1 Q99490

Viewing 1-25 of 25 items
AGAP2 / PIKE Antibody - Anti-AGAP2 / PIKE antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $485.00
AGAP2 / PIKE Antibody - Anti-AGAP2 / PIKE antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
AGAP2 / PIKE Antibody - Anti-AGAP2 / PIKE antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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Goat Polyclonal to Human AGAP2 / PIKE
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
AGAP2 / PIKE Antibody - CENTG1 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The CENTG1 antibody detected the CENTG1 protein (arrow).
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Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Human
WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $435.00
AGAP2 / PIKE Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using AGAP2 Polyclonal Antibody at dilution of 1:30.
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Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Human
ELISA, IHC, WB
Unconjugated
20µl   0.2mg/ml   $205.00; 60µl   0.2mg/ml   $235.00; 120µl   0.2mg/ml   $295.00; 200µl   0.2mg/ml   $395.00
Select
Rabbit Polyclonal to Human AGAP2 / PIKE
Human
ELISA, ICC, WB
Unconjugated
100µl   $365.00
AGAP2 / PIKE Antibody - IHC ofAGAP2 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top left) and Peptide-affinity Purified Polyclonal Antibody to AGAP2 (bottom left, right) at 5 ug/ml.
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Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Rat, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µg   $335.00
AGAP2 / PIKE Antibody - IHC ofAGAP2 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top left) and Peptide-affinity Purified Polyclonal Antibody to AGAP2 (bottom left, right) at 5 ug/ml.
Select
Rabbit Polyclonal to Human AGAP2 / PIKE
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µg   $335.00
AGAP2 / PIKE Antibody
Select
Rabbit Polyclonal to Human AGAP2 / PIKE
Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
AGAP2 / PIKE Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using AGAP2 Polyclonal Antibody at dilution of 1:60.
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Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Human
ELISA, IHC
Unconjugated
20µl   1mg/ml   $205.00; 60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
ELISA, WB
APC Conjugated
200µl   $740.00
AGAP2 / PIKE Antibody - Detection of Human PIKE by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-PIKE antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
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Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Human
IP, WB
Unconjugated
100µl   1mg/ml   $395.00
AGAP2 / PIKE Antibody - AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Bovine, Rat, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
AGAP2 / PIKE Antibody - AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Bovine, Rat, Bat, Gibbon, Human, Monkey
WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
AGAP2 / PIKE Antibody - AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Bovine, Rat, Bat, Gibbon, Human, Monkey
WB
Biotin Conjugated
100µl   1mg/ml   $385.00
AGAP2 / PIKE Antibody - AGAP2 / PIKE antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human AGAP2 / PIKE
Mouse, Bovine, Rat, Bat, Gibbon, Human, Monkey
WB
FITC Conjugated
100µl   1mg/ml   $385.00
Select
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Human
IP
Unconjugated
100µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human AGAP2 / PIKE
Mouse, Human
WB
AP Conjugated
100µl   $295.00; 200µl   $385.00

Viewing 1-25 of 25 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).