TNFRSF1B (TNFR2, CD120b) is a tumor necrosis factor-alpha receptor found on the surface of regulatory T cells. It is functionally involved in regulation of proliferation via the NF-kB pathway, negative apoptotic regulation and neural regeneration. TNFRSF1B is also involved in allergic, inflammatory and immune response, and mutations in the gene have been associated with a number of autoimmune diseases including systemic lupus erythematosus, inflammatory bowel diseases and Crohn’s disease. Furthermore, TNFRSF1B is expressed in many tumors such as colon cancer, ovarian cancer and leukemia where it promotes growth and survival. In immunohistochemistry, TNFRSF1B may be useful in the differential diagnosis of chronic lymphocytic leukemia, where it is upregulated relative to normal plasma cells and tonsillar B lymphocytes. In normal tissues, TNFRSF1B has cytoplasmic and membranous positivity throughout the body.
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