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Mouse IL36RN / IL1F5 Recombinant Protein LS-G3930

Ordering

Wt. Vol. Conc. Price
10 µg - - $275
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular IL36RN / IL1F5 Proteins

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Human IL36RN / IL1F5 Recombinant Protein - LS-G38612
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100% Guaranteed 100% Guaranteed
LS-G3930
Recombinant Protein
IL36RN / IL1F5
Mouse
~17kDa
Mouse IL36Ra (aa Val3-Asp156) is untagged.
aa 3-156
E. coli
E. coli
None
Greater than 95% by SDS-PAGE
Inhibits the IL-6 induced expression of IL-36alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9) in BMDCs. 1µg/ml of IL-36Ra inhibits the activity of 10 ng to 100 ng/ml of the agonists.
Less than 0.05 EU/µg protein (determined by LAL method).
Lyophilized from PBS.
Reconstitute with 100 µl sterile water.
Store lyophilized at -20°C for at least 6 months. Once reconstituted store at +4°C for immediate use.
For research use only.

About IL36RN / IL1F5

Q9UBH0 NM_012275 NP_036407.1

IL36RN Protein, FIL1 Protein, FIL1D Protein, IL-1 delta Protein, IL-1 related protein 3 Protein, IL-1HY1 Protein, IL-1RP3 Protein, IL-1-related protein 3 Protein, IL1F5 Protein, IL1RP3 Protein, IL1L1 Protein, IL36RA Protein, Interleukin-1 delta Protein, Family of interleukin 1-delta Protein, FIL1 delta Protein, IL-1L1 Protein, IL-1ra homolog 1 Protein, Interleukin-1 family member 5 Protein, Interleukin-1-like protein 1 Protein, FIL1(DELTA) Protein, IL-1F5 Protein, IL1HY1 Protein, Interleukin-1 HY1 Protein, PSORP Protein

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation.

Functional Assay

Functional Assay
IL-36Ra (aa 3-156) (mouse) (rec.) inhibits IL-36alpha, IL-36beta, IL-36gamma-dependent expression of IL-6 in mouse BMDCs. Method: Bone marrow cells were differentiated into bone marrow-derived dendritic cells (BMDCs) using GM-CSF (20ng/ml) for 10 days. BMDCs were cultured with or without IL-36Ra, IL-36alpha, IL-36beta, IL-36gamma, or LPS at indicated concentrations for 72 h. Cell supernatants were then harvested and IL-6 levels determined by ELISA.
 

Requested From: United States
Date Requested: 12/10/2016

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