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IL36RN / IL1F5

interleukin 36 receptor antagonist

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.

Gene Name: interleukin 36 receptor antagonist
Family/Subfamily: IL-1 , not assigned-IL-1
Synonyms: IL36RN, FIL1, FIL1D, IL-1 delta, IL-1 related protein 3, IL-1HY1, IL-1RP3, IL-1-related protein 3, IL1F5, IL1RP3, IL1L1, IL36RA, Interleukin-1 delta, Family of interleukin 1-delta, FIL1 delta, IL-1L1, IL-1ra homolog 1, Interleukin-1 family member 5, Interleukin-1-like protein 1, FIL1(DELTA), IL-1F5, IL1HY1, Interleukin-1 HY1, PSORP
Target Sequences: NM_012275 NP_036407.1 Q9UBH0

☰ Filters
Products
Proteins (20)
Over-Expression Lysate (4)
Recombinant (16)
IL36RN / IL1F5 (20)
No (20)
His (2)
His-SUMO (1)
His-T7 (2)
Myc-DDK (Flag) (6)
Bovine (1)
Human (14)
Mouse (3)
293T Cells (2)
E. coli (13)
HEK 293 Cells (4)
Yeast (1)
Purified (3)
Low endotoxin level (5)
Biologically active (4)
IL36RN / IL1F5 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
IL36RN / IL1F5 Protein - IL-36Ra (aa 3-156) (mouse) (rec.) inhibits IL-36alpha, IL-36beta, IL-36gamma-dependent expression of IL-6 in mouse BMDCs. Method: Bone marrow cells were differentiated into bone marrow-derived dendritic cells (BMDCs) using GM-CSF (20ng/ml) for 10 days. BMDCs were cultured with or without IL-36Ra, IL-36alpha, IL-36beta, IL-36gamma, or LPS at indicated concentrations for 72 h. Cell supernatants were then harvested and IL-6 levels determined by ELISA.
Select
E. coli
None
Less than 0.05 EU/µg protein (determined by LAL method).
~17kDa
10 µg/$323
Select
E. coli
None
Less than 0.05 EU/µg protein (determined by LAL method).
~17kDa
10 µg/$323
IL36RN / IL1F5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
16.8 kDa
100 µg/$494
Select
E. coli
None
17.1 kDa
20 µg/$360; 100 µg/$728
IL36RN / IL1F5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
16.8 kDa
100 µg/$494
IL36RN / IL1F5 Protein - Recombinant Interleukin 1 Delta By SDS-PAGE
Select
E. coli
His-T7
21.0 kDa
50 µg/$502; 10 µg/$291; 200 µg/$1,002; 100 µg/$802; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
IL36RN / IL1F5 Protein - Recombinant Interleukin 1 Delta By SDS-PAGE
Select
E. coli
His-T7
19.1 kDa
10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453
IL36RN / IL1F5 Protein
Select
E. coli
His
16.8 kDa
10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$4,401
IL36RN / IL1F5 Protein
Select
E. coli
None
Biologically active
16.8 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
IL36RN / IL1F5 Protein
Select
E. coli
His-SUMO
32.95 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
IL36RN / IL1F5 Protein - Purified recombinant protein IL36RN was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
16.8 kDa
20 µg/$1,107
IL36RN / IL1F5 Protein - Purified recombinant protein IL36RN was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
16.8 kDa
20 µg/$1,107
IL36RN / IL1F5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
16.8 kDa
20 µg/$150
IL36RN / IL1F5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
16.8 kDa
20 µg/$150
IL36RN / IL1F5 Protein
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
20 µg/$291; 100 µg/$526; 1 mg/$2,497
Select
E. coli
None
Biologically active
16.9 kDa
5 µg/$268; 25 µg/$349
IL36RN / IL1F5 Protein - Recombinant Bovine interleukin-1F5 detected using Rabbit anti Bovine interleukin-1F5 as the capture reagent and Rabbit anti Bovine interleukin-1F5:Biotin as the detection reagent followed by Streptavidin:HRP.
Select
Yeast
None
17.1 kDa
5 µg/$390
IL36RN / IL1F5 Protein - Recombinant Human IL-36 Receptor Antagonist Protein/IL-36RN/IL-1F5
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
16.8 kDa
10 µg/$334; 50 µg/$610
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17 kDa
5 µg/$268; 25 µg/$349
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).