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Catalog Number	Size	Price
LS-G137444-20	20 µg	$364
LS-G137444-100	100 µg	$500
LS-G137444-1	1 mg	$1,679

Human RBL2 / RB2 p130 Protein (Recombinant 6His, N-terminus) - LS-G137444

Name: Human RBL2 / RB2 p130 Protein Recombinant 6His, N-terminus | LSBio
Brand: Lifespan BioSciences
SKU: LS-G137444-20
Price: 364.0000 USD
Availability: InStock

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Description:

RBL2 / RB2 p130 Protein LS-G137444 is a Recombinant Human RBL2 / RB2 p130 produced in E. coli 417-616aa with 6His, N-terminus tag(s). For Research Use Only

$364

LS-G137444-20

$500

LS-G137444-100

$1,679

LS-G137444-1

Toll Free North America

206-374-1102

For Research Use Only

Specifications Publications Reviews Request SDS/MSDS

Overview

Description:

RBL2 / RB2 p130 Protein LS-G137444 is a Recombinant Human RBL2 / RB2 p130 produced in E. coli 417-616aa with 6His, N-terminus tag(s). For Research Use Only

Specifications

Type

Recombinant Protein

Target

RBL2 / RB2 p130

Synonyms

RBL2 | p130 | Retinoblastoma-like 2 (p130) | RBR-2 | Rb2 | Retinoblastoma-like protein 2

Species

Human

Modifications

Unmodified

Conjugations

Unconjugated

Tag

6His, N-terminus

Region

417-616aa

Predicted Molecular Weight

27.4 kDa

AA Sequence

TPVSTATHSLSRLHTMLTGLRNAPSEKLEQILRTCSRDPTQAIANRLKEMFEIYSQHFQPDEDFSNCAKEIASKHFRFAEMLYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRV

Expression System

E. coli

Source Species

E. coli

Purification

Greater than 85% by SDS-PAGE

Usage Summary

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Bio-Activity

Not Tested

Endotoxin

Not Tested

Presentation

Lyophilized from Tris, 50% Glycerol

Storage

Store at -80°C for up to 1 year. Avoid freeze-thaw cycles.

Restrictions

For research use only. Intended for use by laboratory professionals.

Guarantee

This protein carries the LSBio 100% Guarantee.