RBL2 / RB2 p130

retinoblastoma-like 2 (p130)

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

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Products

Proteins (6)

Type

Over-Expression Lysate (3)

Recombinant (3)

Target

RBL2 / RB2 p130 (6)

Publications

No (6)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human RBL2 / RB2 p130 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66868

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

128.2 kDa

Price:

20 µg/$1,107

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Human RBL2 / RB2 p130 Protein (Recombinant GST, N-terminus) (aa416-515) - LS-G59879

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RBL2 / RB2 p130 Protein (Over-Expression Lysate His, N-Terminal) (Pro2-His1139) - LS-G96914

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~130 kDa

Price:

100 µg/$298

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Human RBL2 / RB2 p130 Protein (Recombinant 6His, N-terminus) - LS-G137444

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

27.4 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human RBL2 / RB2 p130 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78629

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

128.2 kDa

Price:

20 µg/$150

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RBL2 / RB2 p130 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115854

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

128.2 kDa

Price:

100 µg/$494

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